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Akademický článek
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Autor:
David M. A. Mann
Publikováno v:
Neurobiology of Aging. 6:160-162
The limitations of the application of neural transplantation as a therapeutic measure in degenerative diseases of the human nervous system, such as Alzheimer's disease and Parkinson's disease are discussed. It is concluded that the potential usefulne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e9f6be59261464b006d16c7e58d0d2d
https://doi.org/10.1016/0197-4580(85)90037-5
https://doi.org/10.1016/0197-4580(85)90037-5
Autor:
N.D. LeVere, T.E. Levere
Publikováno v:
Neurobiology of Aging. 6:151-152
Despite the potentially interesting implications of the neural transplantation research reviewed by Gash, Collier and Sladek, several issues related to the functional role of brain grafts are discussed. These issues require careful consideration and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2e7bd4e9bfc317364e7117434a82083
https://doi.org/10.1016/0197-4580(85)90032-6
https://doi.org/10.1016/0197-4580(85)90032-6
Publikováno v:
Cell Transplantation, Vol 20 (2011)
Tau accumulation, in the form of neurofibrillary tangles (NFT), is an early neuropathological characteristic of Alzheimer's disease (AD) and early onset AD frequently seen in Down syndrome (DS). We investigated the presence of tau accumulation in the
Externí odkaz:
https://doaj.org/article/e192c04952be4c18a30173a2c6cf005c
Publikováno v:
Cell Transplantation, Vol 17 (2008)
Degradable polymers have been used successfully in a wide variety of peripheral applications from tissue regeneration to drug delivery. These polymers induce little inflammatory response and appear to be well accepted by the host environment. Their u
Externí odkaz:
https://doaj.org/article/bbb75cfd6ebb43eb9dd43f4b6431a5a8
Autor:
J. R. Sladek Ph.D., K. B. Bjugstad, T. J. Collier, E. A. Bundock, B. C. Blanchard, J. D. Elsworth, R. H. Roth, D. E. Redmond
Publikováno v:
Cell Transplantation, Vol 17 (2008)
Transplantation of embryonic dopamine (DA) neurons has been tested as a therapy for Parkinson's disease. Most studies placed DA neurons into the striatum instead of the substantia nigra (SN). Reconstruction of this DA pathway could serve to establish
Externí odkaz:
https://doaj.org/article/1c8db4ed76da4c3abe500c776d559660
Publikováno v:
Behavioral Neuroscience. 104:564-576
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f34a4c73efa3f9660aeabc618cfcf6a6
https://doi.org/10.1037/0735-7044.104.4.564
https://doi.org/10.1037/0735-7044.104.4.564
Publikováno v:
The Journal of comparative neurology. 426(1)
Survival of embryonic dopamine (DA) neurons is extremely low (5-20%) following transplantation. Strategies to increase this survival are critical to the future of transplantation for Parkinson's disease. We demonstrate here that a factor(s) released
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e362dc150afb87f2d03c582bfd2bc070
https://pubmed.ncbi.nlm.nih.gov/10980489
https://pubmed.ncbi.nlm.nih.gov/10980489
Publikováno v:
The Journal of comparative neurology. 399(4)
To enhance the current therapeutic benefit of dopamine (DA) neuron grafts in Parkinson's disease, strategies must be developed that increase both DA neuron survival and fiber outgrowth into the denervated striatum. Previous work in our laboratory has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c586a66bffac4256babcae368f295b3
https://pubmed.ncbi.nlm.nih.gov/9741481
https://pubmed.ncbi.nlm.nih.gov/9741481