Peritonitis Activates Transcription of the Human Prolactin Locus in Myeloid Cells in a Humanized Transgenic Rat Model

Autor: Raheela Awais, Julian R. E. Davis, Alan S. McNeilly, John J. Mullins, Adriano G. Rossi, Amanda L. Patist, Karen Featherstone, Claire V. Harper, Anne V McNamara, Sabrina Semprini, Ian Dransfield, Michael R. H. White, J R McNeilly

Publikováno v: Endocrinology. 153:2724-2734

Prolactin (PRL) is mainly expressed in the pituitary in rodents, whereas in humans, expression is observed in many extrapituitary sites, including lymphocytes. Due to the lack of adequate experimental models, the function of locally produced PRL in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb0b7e61d465cf4a574b9f9fb6d9494
https://doi.org/10.1210/en.2011-1926

Bone morphogenetic protein-4 interacts with activin and GnRH to modulate gonadotrophin secretion in LβT2 gonadotrophs

Autor: Alan S. McNeilly, J R McNeilly, Faure Mo, L Nicol, Catherine Taragnat, J Fontaine

Publikováno v: Nicol, L, Faure, M-O, McNeilly, J R, Fontaine, J, Taragnat, C & McNeilly, A S 2008, ' Bone morphogenetic protein-4 interacts with activin and GnRH to modulate gonadotrophin secretion in LbetaT2 gonadotrophs ', Journal of Endocrinology, vol. 196, no. 3, pp. 497-507 . https://doi.org/10.1677/JOE-07-0542
The Journal of Endocrinology
Journal of Endocrinology
Journal of Endocrinology, BioScientifica, 2008, 196 (3), pp.497-507. ⟨10.1677/jOE-07-0542⟩
Journal of Endocrinology 3 (196), 497-507. (2008)

International audience; We have shown previously that, in sheep primary pituitary cells, bone morphogenetic proteins (BMP)-4 inhibits FSH beta mRNA expression and FSH release. In contrast, in mouse L beta T2 gonadotrophs, others have shown a stimulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53efa3530f2c65c88f927f2dc21f6e34
https://doi.org/10.1677/joe-07-0542

Loss of Oocytes in Dazl Knockout Mice Results in Maintained Ovarian Steroidogenic Function but Altered Gonadotropin Secretion in Adult Animals

Autor: Philippa T. K. Saunders, Mark Cranfield, Howard J. Cooke, J R McNeilly, Mary Taggart, Alan S. McNeilly

Publikováno v: Endocrinology. 141:4284-4294

Within 2 days of birth, the mouse ovary is mainly composed of oocytes surrounded by a few pregranulosa cells forming primordial follicles that remain quiescent until they are recruited by intraovarian or other unknown factors to initiate growth of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517b3d54384a906cf1f095a0abca06ef
https://doi.org/10.1210/endo.141.11.7764

Characterization of the ovine LHβ-subunit gene: the promoter is regulated by GnRH and gonadal steroids in transgenic mice

Autor: P. Brown, A. J. Clark, John J. Mullins, Alan S. McNeilly, J. R. Mcneilly

Publikováno v: Journal of Endocrinology. 151:481-489

We have previously demonstrated that 1·9 kb of ovine LHβ promoter fused to bacterial chloramphenicol transferase (CAT) coding sequence is sufficient to target expression of the transgene specifically to the gonadotroph cells of the anterior pituita

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034992ea8a5f4be5ba05596bd586faaa
https://doi.org/10.1677/joe.0.1510481

Alterations in Endogenous Gonadotropin Secretion and Pituitary Responsiveness to Gonadotropin-Releasing Hormone in Adult Ewes, Following Indirect Selection in Prepubertal Male Lambs1

Autor: N P Evans, Robert Webb, J R McNeilly

Publikováno v: Biology of Reproduction. 51:913-919

Indirect selection to improve reproductive performance in the female, through use of a physiologically related trait in prepubertal males, the LH response to a GnRH challenge, has created two lines of sheep with altered pituitary gland sensitivity to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3a928b3e889f6b14ad2847fd7b0ad41
https://doi.org/10.1095/biolreprod51.5.913