Výsledky vyhledávání - "J. R. McGhee"

Elektronická kniha

Secretory Immunity and Infection : Proceedings of the International Symposium on the Secretory Immune System and Caries Immunity

Autor: J. R. McGhee

The present conference is the third in a series on this topic sponsored by the NCP. Drs. HcGhee, l1estecky, Genco and Bowen are to be commended for arranging this truly comprehensive program. We are fortunate that they have been able to assemble such

Zobrazit plný text záznamu

A Nontoxic Adjuvant for Mucosal Immunity to Pneumococcal Surface Protein A

Autor: M, Yamamoto, D E, Briles, S, Yamamoto, M, Ohmura, H, Kiyono, J R, McGhee

Publikováno v: The Journal of Immunology. 161:4115-4121

In this study, we demonstrated that pneumococcal surface protein A (PspA) nasally administered with a nontoxic A subunit mutant of cholera toxin (mCT) S61F elicited a protective immune response. Immunization with PspA and mCT elicited higher levels o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5666fea593c326daf05bed3b49c073f
https://doi.org/10.4049/jimmunol.161.8.4115

Zobrazit plný text záznamu

Oral immunization with simian immunodeficiency virus p55gag and cholera toxin elicits both mucosal IgA and systemic IgG immune responses in nonhuman primates

Autor: M Kubota, C J Miller, K Imaoka, S Kawabata, K Fujihashi, J R McGhee, H Kiyono

Publikováno v: The Journal of Immunology. 158:5321-5329

Rhesus macaques were orally immunized with a mucosal vaccine consisting of two different concentrations (1 mg vs 250 microg) of recombinant SIV p55gag (p55) with or without cholera toxin (CT, 50 microg) as a mucosal adjuvant. The plasma from macaques

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eaeab2488d9bc91f516d265879640704
https://doi.org/10.4049/jimmunol.158.11.5321

Zobrazit plný text záznamu

Evidence for CD8+ T-cell immunity to murine rotavirus in the absence of perforin, fas, and gamma interferon

Autor: J L VanCott, Lusijah Rott, J R McGhee, Harry B. Greenberg, C Tin, Manuel A. Franco

Publikováno v: Journal of Virology. 71:479-486

We recently showed that class I-restricted CD8+ T cells mediate clearance of primary rotavirus infection in mice: JHD knockout (JHD -/-) (B-cell-deficient) mice depleted of CD8+ T cells become chronically infected with murine rotavirus, and beta2 mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f994c77310f07d4c57cb70918eabf7
https://doi.org/10.1128/jvi.71.1.479-486.1997

Zobrazit plný text záznamu

Peritoneal cavity CD5 (Bla) B cells: Cytokine induced IgA secretion and homing to intestinal lamina propria in SCID mice

Autor: A M Murray, Kenneth W. Beagley, J. R. McGhee, JH Eldridge

Publikováno v: Immunology and Cell Biology. 73:425-432

The mouse peritoneal cavity contains a unique population of B cells (Bla) with a high IgM/low IgD ratio, CD5+ (Ly1), MAC-1 + phenotype. These cells arise early in ontogeny, utilize a limited repertoire of immunoglobulin V genes, produce polyreactive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e89012ce72afb006ec1b3b261520f1a
https://doi.org/10.1038/icb.1995.66

Zobrazit plný text záznamu

Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine

Autor: K W Beagley, K Fujihashi, A S Lagoo, S Lagoo-Deenadaylan, C A Black, A M Murray, A T Sharmanov, M Yamamoto, J R McGhee, C O Elson

Publikováno v: The Journal of Immunology. 154:5611-5619

Intraepithelial lymphocytes (IELs) have been extensively studied in the murine small intestine. However, to date no studies have assessed IEL in the large intestine, despite the marked differences in function and lumenal environment. In the present s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcde7b4c009ad85a405fb2fd1c98cc40
https://doi.org/10.4049/jimmunol.154.11.5611

Zobrazit plný text záznamu

alpha beta T cell receptor-positive intraepithelial lymphocytes with CD4+, CD8- and CD4+, CD8+ phenotypes from orally immunized mice provide Th2-like function for B cell responses

Autor: K Fujihashi, M Yamamoto, J R McGhee, H Kiyono

Publikováno v: The Journal of Immunology. 151:6681-6691

Our previous studies have shown that murine alpha beta TCR+ intraepithelial lymphocytes (IEL) contained T cells that can provide B cell help. In this study, we have examined the three subsets of alpha beta TCR+ IEL for Ag-specific helper function and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90bbcfce0dd7693cd166a5f46d33eb94
https://doi.org/10.4049/jimmunol.151.12.6681

Zobrazit plný text záznamu

Transforming growth factor-beta and IL-1 beta act in synergy to enhance IL-6 secretion by the intestinal epithelial cell line, IEC-6

Autor: D W McGee, K W Beagley, W K Aicher, J R McGhee

Publikováno v: The Journal of Immunology. 151:970-978

Intestinal epithelial cells are a potentially important source for a number of cytokines that may modulate the immune response at the intestinal mucosa. We have recently begun to study the mechanisms that regulate IL-6 production by intestinal epithe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea0a16494b26b24c66a3d805e33c2c7e
https://doi.org/10.4049/jimmunol.151.2.970

Zobrazit plný text záznamu

Cytokine- and Ig-producing T cells in mucosal effector tissues: analysis of IL-5- and IFN-gamma-producing T cells, T cell receptor expression, and IgA plasma cells from mouse salivary gland-associated tissues

Autor: J Mega, J R McGhee, H Kiyono

Publikováno v: The Journal of Immunology. 148:2030-2039

The present study has focused on the analysis of cytokine- and Ig-producing mononuclear cells (MC) that reside in the salivary glands and their associated tissues (SGAT) in the oral region. The SGAT are located under the mandibular area and consist o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74556cd880aea88a48f9ed05f302128d
https://doi.org/10.4049/jimmunol.148.7.2030

Zobrazit plný text záznamu

Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5

Autor: T Taguchi, W K Aicher, K Fujihashi, M Yamamoto, J R McGhee, J A Bluestone, H Kiyono

Publikováno v: The Journal of Immunology. 147:3736-3744

Intestinal intraepithelial lymphocytes (IEL) from mice are greater than 80% CD3+ T cells and could be separated into four subsets according to expression of CD4 and CD8. In our studies designed to assess the functions of IEL, namely, cytokine product

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70665ea3497b747ea043f5a3c0ca2b5c
https://doi.org/10.4049/jimmunol.147.11.3736

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání