Zobrazeno 1 - 10
of 21
pro vyhledávání: '"J. R. McCullough"'
Publikováno v:
Chirality. 10:262-272
Airways of asthma patients can become hyperresponsive to airway spasmogens following regular use of isoprenaline or beta 2-selective sympathomimetics. Hyper-reactivity that results from acute exposure of animals to these drugs is pre-empted by vagal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c17a9980145e3dd9928f89faacbe46c
https://doi.org/10.1002/(sici)1520-636x(1998)10:3<262::aid-chir9>3.0.co
https://doi.org/10.1002/(sici)1520-636x(1998)10:3<262::aid-chir9>3.0.co
Modulation of rabbit aortic Ca(2+)-activated K+ channels by pinacidil, cromakalim, and glibenclamide
Autor:
J. R. McCullough, G. H. Gelband
Publikováno v:
American Journal of Physiology-Cell Physiology. 264:C1119-C1127
Rabbit aortic smooth muscle microsomes were isolated and large-conductance Ca(2+)-activated K+ (BK) channels incorporated into planar lipid bilayers. The selectivity sequence and relative permeability ratios for monovalent cations was K+ (1.0) > Rb+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b66f524423eb8abddc7bf5b587034c
https://doi.org/10.1152/ajpcell.1993.264.5.c1119
https://doi.org/10.1152/ajpcell.1993.264.5.c1119
Autor:
Yogesh C. Agrawal, J. R. McCullough
Publikováno v:
Applied optics. 20(9)
The spatial structure of the optical field on the detector of a laser Doppler velocimeter is examined. It is shown that for sufficiently small scatterers, the optical field is a traveling wave of shape determined by the detector optics alone. The dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31946e1394515490c58c8b07a6fe255
https://pubmed.ncbi.nlm.nih.gov/20309349
https://pubmed.ncbi.nlm.nih.gov/20309349
Publikováno v:
Circulation Research. 66:191-201
Cells in many specimens of human ventricle can exhibit either of two stable levels of diastolic potential (DP) when exposed to 4 mM K+ in vitro (i.e., -78 +/- 4 mV or -45 +/- 5 mV, mean +/- SEM). In this report we show that the DP of some partially d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0453f519bb5e5bd692828d2efa2e3d87
https://doi.org/10.1161/01.res.66.1.191
https://doi.org/10.1161/01.res.66.1.191
Publikováno v:
British journal of pharmacology. 131(2)
1. The cardiac electrophysiological effects of S-oxybutynin, a single-enantiomer drug under evaluation for the management of urinary incontinence, have been investigated and compared with those of terodiline, an incontinence agent withdrawn following
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44ae5f02c2e788a4e175e86d59288349
https://pubmed.ncbi.nlm.nih.gov/10991917
https://pubmed.ncbi.nlm.nih.gov/10991917
Publikováno v:
British journal of pharmacology. 127(8)
1. Terodiline, an anticholinergic/antispasmodic drug effective in the treatment of urinary incontinence, is presently restricted due to adverse side effects on cardiac function. To characterize its effects on cardiac L-type Ca2+-channel current carri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f1de1fa7a2e520e2a2a87aee2847d3ce
https://pubmed.ncbi.nlm.nih.gov/10482914
https://pubmed.ncbi.nlm.nih.gov/10482914
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(3)
Terodiline was widely prescribed for urinary incontinence before reports of adverse cardiac effects that included bradycardia, QT lengthening, and ventricular tachyarrhythmia. The present study on guinea pig papillary muscles and ventricular myocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1dcb48d27a5bd5e7fbcb6fb92646bda
https://pubmed.ncbi.nlm.nih.gov/10454521
https://pubmed.ncbi.nlm.nih.gov/10454521
Publikováno v:
Arzneimittel-Forschung. 48(10)
Racemic oxybutynin (CAS 1508-65-2) is used clinically to treat urinary incontinence and reportedly undergoes N-deethylation to metabolites R- and/or S-desethyloxybutynin. To assess the role of these metabolites in the therapeutic effects of oxybutyni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2033c056618ac7f81320db308597ecc1
https://pubmed.ncbi.nlm.nih.gov/9825119
https://pubmed.ncbi.nlm.nih.gov/9825119
Publikováno v:
Chirality. 10(3)
Airways of asthma patients can become hyperresponsive to airway spasmogens following regular use of isoprenaline or beta 2-selective sympathomimetics. Hyper-reactivity that results from acute exposure of animals to these drugs is pre-empted by vagal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c234ba268104d3ae8e21e6ced15fbb26
https://pubmed.ncbi.nlm.nih.gov/9499574
https://pubmed.ncbi.nlm.nih.gov/9499574
Autor:
David W. Paquette, R J Oringer, T. H. Howell, J. R. McCullough, Gianluca Martuscelli, Joseph P. Fiorellini, Ray C. Williams, David S. Reasner
Publikováno v:
Journal of clinical periodontology. 24(8)
Systemic and topical administration of non-steroidal anti-inflammatory drugs (NSAIDs) has been shown to reduce periodontal disease progression in both animal models and human subjects. Our present research focuses on single enantiomers of these agent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e7183a5b80f2e69a7021c2823f4598
https://pubmed.ncbi.nlm.nih.gov/9266337
https://pubmed.ncbi.nlm.nih.gov/9266337