Výsledky vyhledávání - "J. R. K. Savage"

Brief communication: Is there a simple answer to the origin of complex chromosome exchanges?

Publikováno v: International Journal of Radiation Biology. 75:19-22

(1999). Brief communication: Is there a simple answer to the origin of complex chromosome exchanges? International Journal of Radiation Biology: Vol. 75, No. 1, pp. 19-22.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc3fb91b6e671dac74d95571767bc55c
https://doi.org/10.1080/095530099140762

Zobrazit plný text záznamu

Interphase chromosome domain re-organization following irradiation

Autor: M. Figgitt, J. R. K. Savage

Publikováno v: International journal of radiation biology. 75(7)

To investigate chromosome domain movements during interphase in stationary cell nuclei.Contact-inhibited primary human fibroblasts were irradiated with 4.0 Gy X-rays, BrdU was added, and air-dried cell preparations made at intervals up to 48 h. Chrom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29630d0933f87ac48591e86a8d86112f
https://pubmed.ncbi.nlm.nih.gov/10489892

Zobrazit plný text záznamu

Investigating the nature of chromatid breaks produced by restriction endonucleases

Autor: J. R. K. Savage, A. N. Harvey

Publikováno v: International journal of radiation biology. 71(1)

It is a basic assumption of the breakage-and-reunion theory that the majority of open chromatid breaks seen at metaphase are the residue of unrejoined primary breaks that have neither restituted nor rejoined illegitimately to form exchange aberration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b211b5e281c5d13eda1e5db7ed2f7dd
https://pubmed.ncbi.nlm.nih.gov/9020959

Zobrazit plný text záznamu

Detecting 'hidden' exchange events within X-ray-induced aberrations using multicolour chromosome paints

Autor: P. J. Simpson, J. R. K. Savage

Publikováno v: Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 3(1)

In a recent series of papers we pointed out that any complex exchange (an interaction involving three or more breaks) can yield a wide range of aberration configurations. If these aberrations are detected with a single chromosome paint and total cent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f72f2cfd9e7d50f838cbe7679d27849
https://pubmed.ncbi.nlm.nih.gov/7704420

Zobrazit plný text záznamu

Investigations of Aberration Origins Using BrdUrd

Autor: A. N. Harvey, J. R. K. Savage

Publikováno v: Chromosomal Alterations ISBN: 9783642788895

The thymidine analogue 5-bromodeoxyuridine (BrdUrd) will be incorporated into DNA if present during S-phase. The predominant semi-conservative segregation of the newly synthesised strands is reflected at the chromosome level. Thus, after one S-phase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38ef154eb1ec902641bc0b1ccf754d62
https://doi.org/10.1007/978-3-642-78887-1_9

Zobrazit plný text záznamu

Excogitations About the Quantification of Structural Chromosomal Aberrations

Autor: J. R. K. Savage, D. G. Papworth

Publikováno v: Advances in Mutagenesis Research ISBN: 9783642762345

From the early days of interest in genetics and mutation, chromosomal structural changes (“aberrations”) have always been an important endpoint for both theoretical and experimental studies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de926ea29d36cab8976cbea5dc2f1942
https://doi.org/10.1007/978-3-642-76232-1_6

Zobrazit plný text záznamu

BrdU pulse/reverse staining protocols for investigating chromosome replication

Autor: J. R. K. Savage, S. Z. Aghamohammadi

Publikováno v: Chromosoma. 99(1)

By using a reverse Giemsa staining procedure (TT chromatin pale, TB chromatin dark) it is possible to detect replication in metaphase chromosomes with short (approximately 10 min) 5-bromodeoxyuridine (BrdU) pulses. A pulse protocol allows us to consi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da894ab3b5459b6457e7895433ac7920
https://pubmed.ncbi.nlm.nih.gov/1692785

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání