Výsledky vyhledávání - "J. R. Jasper"

Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine

Autor: A B, Malmberg, L R, Hedley, J R, Jasper, J C, Hunter, A I, Basbaum

Publikováno v: British journal of pharmacology. 132(8)

There is evidence that noradrenaline contributes to the development and maintenance of neuropathic pain produced by trauma to a peripheral nerve. It is, however, unclear which subtype(s) of alpha adrenergic receptors (AR) may be involved. In addition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f4356b77dde72501c9a8b961c6af9a4
https://pubmed.ncbi.nlm.nih.gov/11309255

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Imidazoline-binding domains on monoamine oxidase B and subpopulations of enzyme

Autor: R, Raddatz, S L, Savic, V, Bakthavachalam, J, Lesnick, J R, Jasper, C R, McGrath, A, Parini, S M, Lanier

Publikováno v: The Journal of pharmacology and experimental therapeutics. 292(3)

A series of phenoxy-substituted methylimidazoline derivatives were synthesized and used to define the ligand recognition properties of the imidazoline-binding domain (IBD) on monoamine oxidase (MAO)-B and its role in substrate processing. The rank or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1287bdd94fbf4be3836f30d5d7129431
https://pubmed.ncbi.nlm.nih.gov/10688633

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Cardiovascular effects of rilmenidine, moxonidine and clonidine in conscious wild-type and D79N alpha2A-adrenoceptor transgenic mice

Autor: Q M, Zhu, J D, Lesnick, J R, Jasper, S J, MacLennan, M P, Dillon, R M, Eglen, D R, Blue

Publikováno v: British journal of pharmacology. 126(6)

1. We investigated the cardiovascular effects of rilmenidine, moxonidine and clonidine in conscious wild-type and D79N alpha2A-adrenoceptor mice. The in vitro pharmacology of these agonists was determined at recombinant (human) alpha2-adrenoceptors a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b35f0ade20eb3b6a4bf650892cbe590c
https://pubmed.ncbi.nlm.nih.gov/10217548

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Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding

Autor: J R, Jasper, J D, Lesnick, L K, Chang, S S, Yamanishi, T K, Chang, S A, Hsu, D A, Daunt, D W, Bonhaus, R M, Eglen

Publikováno v: Biochemical pharmacology. 55(7)

Alpha-2 adrenergic receptors (alpha2 AR) mediate incorporation of guanosine 5'-O-(gamma-thio)triphosphate ([35S]GTPgammaS) into isolated membranes via receptor-catalyzed exchange of [35S]GTPgammaS for GDP. In the current study, we used [35S]GTPgammaS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0da41f98090bac9c267383b076ee225a
https://pubmed.ncbi.nlm.nih.gov/9605427

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Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice

Autor: J C, Hunter, D J, Fontana, L R, Hedley, J R, Jasper, R, Lewis, R E, Link, R, Secchi, J, Sutton, R M, Eglen

Publikováno v: British journal of pharmacology. 122(7)

1. The role of alpha2-adrenoceptor (AR) subtypes in the modulation of acute nociception, motor behaviour and body temperature, has been investigated by determining the activity of the alpha2AR selective agonist dexmedetomidine (Dex) in mice devoid of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9941dfe39e384227719b1f67177a7eee
https://pubmed.ncbi.nlm.nih.gov/9421280

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Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b)

Autor: J R, Jasper, A, Kosaka, Z P, To, D J, Chang, R M, Eglen

Publikováno v: British journal of pharmacology. 122(1)

1. The rat 5-hydroxytryptamine (5-HT)7 receptor displays two splice variations, a long form, and a truncated splice isoform, arising from the introduction of a stop codon near the carboxy-terminus. The human-5HT7 receptor gene contains at least two i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2e689bfe3f991aa4a23499226a22fca8
https://pubmed.ncbi.nlm.nih.gov/9298538

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Progress in the development of oxytocin antagonists for use in preterm labor

Autor: D J, Pettibone, M, Guidotti, C M, Harrell, J R, Jasper, E V, Lis, J A, O'Brien, D R, Reiss, C J, Woyden, M G, Bock, B E, Evans

Publikováno v: Advances in experimental medicine and biology. 395

From a targeted screening effort and medicinal chemistry program, L-368,899 was selected as the first orally-active oxytocin (OT) antagonist to enter clinical trials. In animal studies, L-368,899 was shown to be a potent and selective OT antagonist a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7bb48ac51478f41355019368a957d0e0
https://pubmed.ncbi.nlm.nih.gov/8714024

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Alteration in Gs-mediated signal transduction in S49 lymphoma cells treated with inhibitors of microtubules

Autor: D, Leiber, J R, Jasper, A A, Alousi, J, Martin, D, Bernstein, P A, Insel

Publikováno v: The Journal of biological chemistry. 268(6)

We have assessed the possible interaction between the microtubular component of the cytoskeleton and signal transducing GTP-binding (G) proteins by examining the ability of colchicine and vinblastine (two microtubule disrupters) to alter Gs and Gi pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e91b4f75ce9bbe05954b215b5113e3fa
https://pubmed.ncbi.nlm.nih.gov/8095044

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