Výsledky vyhledávání - "J. R. Florini"

Raf-1 activation stimulates proliferation and inhibits IGF-stimulated differentiation in L6A1 myoblasts

Autor: D. Z. Ewton, S. A. Coolican, Derina S. Samuel, F. J. Mcwade, T. D. Petley, J. R. Florini

Publikováno v: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 31(2-3)

Our previous work has demonstrated that the insulin-like growth factors (IGFs), acting through a single receptor, stimulate both proliferation and differentiation of L6A1 myoblasts. This unique model system has enabled us to closely examine the switc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783851529d1ecde9531a16fd4b4c6461
https://pubmed.ncbi.nlm.nih.gov/10226782

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Modulation of insulin-like growth factor actions in L6A1 myoblasts by insulin-like growth factor binding protein (IGFBP)-4 and IGFBP-5: a dual role for IGFBP-5

Autor: D Z, Ewton, S A, Coolican, S, Mohan, S D, Chernausek, J R, Florini

Publikováno v: Journal of cellular physiology. 177(1)

We have previously shown that the insulin-like growth factors (IGFs) stimulate both proliferation and differentiation of skeletal muscle cells in culture, and that these actions in L6A1 muscle cells may be modulated by three secreted IGF binding prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2aef15f7801f9775737c09ada728a2d
https://pubmed.ncbi.nlm.nih.gov/9731744

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Stimulation of myogenic differentiation by a neuregulin, glial growth factor 2. Are neuregulins the long-sought muscle trophic factors secreted by nerves?

Autor: J R, Florini, D S, Samuel, D Z, Ewton, C, Kirk, R M, Sklar

Publikováno v: The Journal of biological chemistry. 271(22)

It has long been known that nerves stimulate growth and maintenance of skeletal muscles in ways not dependent on physical contacts, but numerous attempts to identify and characterize the myotrophic agent(s) secreted by nerves have been unsuccessful.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d5ae5e3b2f4a5d687b34c66fb265068e
https://pubmed.ncbi.nlm.nih.gov/8663030

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IGF binding proteins-4, -5 and -6 may play specialized roles during L6 myoblast proliferation and differentiation

Autor: J R Florini, D Z Ewton

Publikováno v: The Journal of endocrinology. 144(3)

It is well known that IGFs-I and -II stimulate both the proliferation and differentiation of myoblasts, but the role of the IGF binding proteins (IGFBPs) during these processes has not been established. In this study we show that IGF-I analogs with g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201bfc4c3f8e38b5857ccff4c089f6e7
https://pubmed.ncbi.nlm.nih.gov/7537792

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Actions of anabolic hormones and growth factors on cultured neonatal heart cells

Autor: J R, Florini, D Z, Ewton

Publikováno v: Growth regulation. 5(1)

The effects of a series of major anabolic hormones on incorporation of labeled precursors into protein and DNA were measured in cardiac myocytes from neonatal rats. IGF-I, TGF beta, and insulin all stimulated [3H] leucine incorporation into protein;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d4107e6dcd4047bc033256a9de2a0a1
https://pubmed.ncbi.nlm.nih.gov/7749347

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IGF-I regulation of elastogenesis: comparison of aortic and lung cells

Autor: D. Z. Ewton, M. Bashir, Bernice M. Martin, Judith Ann Foster, Celeste B. Rich, J. R. Florini, J. Rosenbloom

Publikováno v: The American journal of physiology. 263(2 Pt 1)

Rat neonatal aortic smooth muscle and pulmonary fibroblast cell cultures were exposed to different amounts of insulin-like growth factor-I (IGF-I, 1-100 ng/ml of medium) for 24 h. Aortic smooth muscle cells exhibited an increase in both steady-state

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451cd691cd43d40df0c212d183758a93
https://pubmed.ncbi.nlm.nih.gov/1325131

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The role of the IGFs in myogenic differentiation

Autor: K A, Magri, D Z, Ewton, J R, Florini

Publikováno v: Advances in experimental medicine and biology. 293

Of the three families of growth factors/hormones (the FGFs, TGF-betas, and IGFs) that have major effects on the differentiation of skeletal muscle cells, only the IGFs stimulate the process; indeed, the IGFs are the only well-defined agents thus far

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7cf8270b4b8d769237c9339245bbc636
https://pubmed.ncbi.nlm.nih.gov/1662869

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Highly specific inhibition of IGF-I-stimulated differentiation by an antisense oligodeoxyribonucleotide to myogenin mRNA. No effects on other actions of IGF-T

Autor: J R, Florini, D Z, Ewton

Publikováno v: The Journal of biological chemistry. 265(23)

Myogenin is a member of the recently discovered family of muscle determination genes that have been shown to induce myogenic differentiation in nonmuscle cells and to be closely correlated with terminal differentiation in myoblasts. An antisense olig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d53c54873717be881bb885a84ff8184
https://pubmed.ncbi.nlm.nih.gov/1696254

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Effects of growth factors on myogenic differentiation

Autor: K. A. Magri, J. R. Florini

Publikováno v: American Journal of Physiology-Cell Physiology. 256:C701-C711

It has now been well established that the terminal differentiation of muscle cells in culture is subject to control by hormones and growth factors in the incubation medium. Thus far the most potent and most extensively studied agents are fibroblast g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b25b9e3cc4c3d7b054e19497bfabc5d
https://doi.org/10.1152/ajpcell.1989.256.4.c701

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