Zobrazeno 1 - 10 of 46 pro vyhledávání: '"J. R. Downing"'
1
Induction of phosphorylation of human immunodeficiency virus type 1 Nef and enhancement of CD4 downregulation by phorbol myristate acetate
Autor: Tianci Luo, J V Garcia, J R Downing
Publikováno v: Journal of Virology. 71:2535-2539
The nef gene of the human and simian immunodeficiency viruses (HIV and SIV) encodes a 27 to 34 kDa myristoylated protein that induces downregulation of CD4 from the cell surface and enhances virus infectivity. As shown by experiments on SIV-infected
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e540065e6bf6f3dbbf41a9d004025a
https://doi.org/10.1128/jvi.71.3.2535-2539.1997
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2
The der(11)-encoded MLL/AF-4 fusion transcript is consistently detected in t(4;11)(q21;q23)-containing acute lymphoblastic leukemia
Autor: J R, Downing, D R, Head, S C, Raimondi, A J, Carroll, A M, Curcio-Brint, T A, Motroni, M G, Hulshof, D J, Pullen, P H, Domer
Publikováno v: Blood. 83:330-335
The t(4;11)(q21;q23) is the most common translocation involving band 11q23 and is found predominantly in acute lymphoblastic leukemias (ALLs) of infants. Recent studies have shown that this translocation involves the MLL gene on chromosome 11 and the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645ff1e0c26790db2f8c87cc908d05f3
https://doi.org/10.1182/blood.v83.2.330.bloodjournal832330
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3
NPM-ALK Reverse Transcriptase-Polymerase Chain Reaction Analysis for Detection of the t(2;5) Translocation of Non-Hodgkin's Lymphoma
Autor: S A, Shurtleff, J R, Downing, S W, Morris
Publikováno v: Methods in molecular medicine. 6
The diagnosis and classification of non-Hodgkin's lymphoma (NHL) has traditionally been made based on morphologic and mununophenotypic criteria. Unfortunately, because of the diverse nature of this group of diseases, rehante solely on these criteria
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c5de32269bdcad1c13ece3d9f856c48
https://pubmed.ncbi.nlm.nih.gov/21380699
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4
NPM-ALK Reverse Transcriptase-Polymerase Chain Reaction for Detecting the t(2;5) of Non-Hodgkin's Lymphoma
Autor: S A, Shurtleff, J R, Downing, S W, Morris
Publikováno v: Methods in molecular medicine. 55
The development of modern molecular biology techniques and their use in characterizing the genetic abnormalities that are of pathogenic significance in non-Hodgkin's lymphoma (NHL) now provides a means to diagnose and rationally subcategorize these n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b1f505a3061442df4a4154b5871df72c
https://pubmed.ncbi.nlm.nih.gov/21312108
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5
Acute leukemia: subtype discovery and prediction of outcome by gene expression profiling
Autor: J R, Downing
Publikováno v: Verhandlungen der Deutschen Gesellschaft fur Pathologie. 87
Contemporary treatment of acute leukemia requires the accurate assignment of patients at diagnosis to specific risk groups. To determine whether gene expression profiling could enhance risk assignment, we used oligonucleotide microarrays to analyze t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c363e99a0e1c730630a339188bb9b910
https://pubmed.ncbi.nlm.nih.gov/16888896
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6
Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia
Autor: C H, Pui, M V, Relling, J T, Sandlund, J R, Downing, D, Campana, W E, Evans
Publikováno v: Annals of hematology. 83
The current cure rate of 80% in childhood acute lymphoblastic leukemia (ALL) attests to the effectiveness of risk-directed therapy developed through well-designed clinical trials. The ongoing Total Therapy Study XV at St. Jude Children's Research Hos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c2cb891155d916c3efc98cd7bcc507e
https://pubmed.ncbi.nlm.nih.gov/15124703
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7
Lack of BCL10 mutations in multiple myeloma and plasma cell leukemia
Autor: L Y, Shih, J F, Fu, S A, Shurtleff, S W, Morris, J R, Downing
Publikováno v: Genes, chromosomescancer. 30(4)
To determine whether the BCL10 mutation plays a role in the oncogenesis of plasma cell dyscrasias, we used polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) and direct sequencing analysis and examined the genomic BCL10 muta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59dc0cb29d62082ccdfa352e036f085a
https://pubmed.ncbi.nlm.nih.gov/11241793
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9
Pathobiology and clinical significance of molecular genetic findings in childhood tumors
Autor: J E, Rubnitz, J R, Downing, W M, Crist
Publikováno v: Advances in pediatrics. 45
Molecular genetic determinants of malignant diseases in children are providing insights into the mechanisms of malignancies. These findings have improved diagnosis, treatment, and prognosis.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0479075c062c09cd2a43e143ac2d4044
https://pubmed.ncbi.nlm.nih.gov/9742307
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10
12p abnormalities and the TEL gene (ETV6) in childhood acute lymphoblastic leukemia
Autor: S C, Raimondi, S A, Shurtleff, J R, Downing, J, Rubnitz, S, Mathew, M, Hancock, C H, Pui, G K, Rivera, G C, Grosveld, F G, Behm
Publikováno v: Blood. 90(11)
Although abnormalities involving the short arm of chromosome 12 (12p) are one of the most frequently observed rearrangements in childhood acute lymphoblastic leukemia (ALL), little is known about the frequency of different structural abnormalities an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e5a56e97934a7805dca4a20b37bd2f43
https://pubmed.ncbi.nlm.nih.gov/9373267
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