Zobrazeno 1 - 10
of 54
pro vyhledávání: '"J. R. Dedman"'
Publikováno v:
Journal of Biological Chemistry. 269:32464-32468
Ca(2+)-activated Cl- current (ICl,Ca) in colonic T84 cells is inhibited by the specific peptide inhibitor of Ca2+/calmodulin-dependent kinase II (CaM KII). Annexin IV, a Ca(2+)-dependent phospholipid binding protein also inhibits Ca(2+)-dependent ani
Publikováno v:
Journal of Biological Chemistry. 267:8411-8416
The cystic fibrosis (CF) phenotype is characterized by a regulatory defect in Cl- permeability in epithelia. A gene (250,000 base pairs) that is associated with this autosomal genetic disorder has been identified. To determine the cellular function o
Publikováno v:
Cell Regulation. 1:165-172
Autor:
B A, Seaton, J R, Dedman
Publikováno v:
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 11(4)
The annexins are a family of proteins that bind anionic phospholipid surfaces in a Ca(2+)-dependent manner (general reviews include RaynalPollard 1994, SwairjoSeaton 1994, Seaton 1996, Mollenhauer, 1997). Due to this functional property, individual a
Publikováno v:
Journal of Biological Chemistry. 265:4567-4569
We have purified annexin V, a monomeric 35-kDa protein, from rat kidney using calcium-dependent phospholipid chromatography. The identity of annexin V was confirmed by immunoblot analysis using monospecific anti-annexin V antibody. Large single cryst
Publikováno v:
The Journal of comparative neurology. 368(3)
The annexins are a family of Ca(2+)-dependent phospholipid-binding proteins. In the present study, the spatial expression patterns of annexins I-VI were evaluated in the rat dorsal root ganglia (DRG) and spinal cord (SC) by using indirect immunofluor
Publikováno v:
The Journal of biological chemistry. 269(51)
Ca(2+)-activated Cl- current (ICl,Ca) in colonic T84 cells is inhibited by the specific peptide inhibitor of Ca2+/calmodulin-dependent kinase II (CaM KII). Annexin IV, a Ca(2+)-dependent phospholipid binding protein also inhibits Ca(2+)-dependent ani
Publikováno v:
The Journal of biological chemistry. 269(7)
The cellular function of annexin IV was evaluated by correlating tissue expression, cellular localization, and whole-cell electrophysiology. Immunolocalization and biochemical data demonstrate that annexin IV is concentrated along the apical membrane
Publikováno v:
The Journal of biological chemistry. 269(1)
Intestinal chloride (Cl-) secretion can be induced by the heat-stable enterotoxin (STa) from Escherichia coli via generation of cGMP. We investigated the regulatory pathway responsible for cGMP-mediated Cl- secretion in the human colonic carcinoma ce
Publikováno v:
The Journal of biological chemistry. 268(31)
The interaction of short amino acid sequences is the basis of molecular recognition and biological regulation in many cellular systems. Libraries of random peptides provide an approach to identify peptides that can be used to modulate, in a targeted