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Safety and efficacy of PNU-142633, a selective 5-HT1D agonist, in patients with acute migraine

Autor: B, Gomez-Mancilla, N R, Cutler, M T, Leibowitz, E L, Spierings, J A, Klapper, S, Diamond, J, Goldstein, T, Smith, J R, Couch, J, Fleishaker, N, Azie, D E, Blunt

Publikováno v: Cephalalgia. 21:727-732

In this randomized, double-blind, placebo-controlled, parallel-group study, patients received a single 50-mg oral dose of a 5-HT(1D) agonist, PNU-142633 (n = 34), or matching placebo (n = 35) during an acute migraine attack. No statistically signific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70f35fbd2ef9c424241a2d961fa45a7
https://doi.org/10.1046/j.1468-2982.2001.00208.x

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Multimechanistic (sumatriptan-naproxen) early intervention for the acute treatment of migraine

Autor: S D, Silberstein, L K, Mannix, J, Goldstein, J R, Couch, S C, Byrd, M H, Ames, S A, McDonald, S E, Lener, Cynthia, Toso

Publikováno v: Neurology. 71(2)

Research suggests treating a migraine at the first sign of pain increases the likelihood of the best clinical outcome.To investigate the efficacy and tolerability of a fixed-dose, single-tablet formulation of sumatriptan 85 mg, formulated with RT Tec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efdb285439885ab550bfcced3c8fca7
https://pubmed.ncbi.nlm.nih.gov/19365064

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Medication overuse headache

Autor: M E, Lenaerts, J R, Couch

Publikováno v: Minerva medica. 98(3)

Medication overuse headache is a common feature underlying chronic headache, especially migraine. It also represents a major therapeutic challenge, especially in headache specialty clinics where it can represent the majority of patients. The syndrome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6057782eba82a6146dcf9bba9474fdab
https://pubmed.ncbi.nlm.nih.gov/17592444

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A study to determine the accuracy of a computerized algorithm for interpretation of EEGs

Autor: K J, Oommen, G E, Gilson, J W, Nelson, J R, Couch

Publikováno v: The Journal of the Oklahoma State Medical Association. 94(9)

The main use of computerized EEG has been in sleep studies. A comprehensive system of interpreting routine EEGs by computers has not yet been developed and is technically difficult. We have tried to incorporate computers in the analysis and interpret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3db1e612c244d2c515b57da22ac7535
https://pubmed.ncbi.nlm.nih.gov/11577629

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Treatment of migraine with BMS180048: response at 2 hours. North American BMS180048 Study Group

Autor: J R, Couch, J, Saper, J P, Meloche

Publikováno v: Headache. 36(9)

BMS180048 is a 5HT agonist that was well-tolerated in early phase II trials. This study utilized a double-blind, parallel-group dose ranging format, comparing BMS180048 in doses of 25, 50, or 75 mg to placebo in effectiveness of treatment of a single

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e93ee0d21b096b0e5d1f494a8a3246d
https://pubmed.ncbi.nlm.nih.gov/8916559

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Onset of neurologic deficits after treatment with dihydroergotamine in a patient with sagittal sinus thrombosis

Autor: M. W. Ghobrial, M. S. Evans, D. K. Naritoku, J. R. Couch

Publikováno v: Clinical neuropharmacology. 19(2)

A woman with a 7-year history of intermittent migraine had 3 months of gradually worsening headaches. Initial neurologic examination including fundus examination was normal, and initial head computerized tomographic (CT) scan and magnetic resonance i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e190f05c0b97a931c1c9e2e0420305da
https://pubmed.ncbi.nlm.nih.gov/8777772

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