Zobrazeno 1 - 10
of 2 208
pro vyhledávání: '"J. Pugh"'
Autor:
Philip Barbulescu, Chetan K. Chana, Matthew K. Wong, Ines Ben Makhlouf, Jeffrey P. Bruce, Yuqing Feng, Alexander F. A. Keszei, Cassandra Wong, Rukshana Mohamad-Ramshan, Laura C. McGary, Mohammad A. Kashem, Derek F. Ceccarelli, Stephen Orlicky, Yifei Fang, Huihui Kuang, Mohammad Mazhab-Jafari, Rossanna C. Pezo, Ashok S. Bhagwat, Trevor J. Pugh, Anne-Claude Gingras, Frank Sicheri, Alberto Martin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract A diverse antibody repertoire is essential for humoral immunity. Antibody diversification requires the introduction of deoxyuridine (dU) mutations within immunoglobulin genes to initiate somatic hypermutation (SHM) and class switch recombina
Externí odkaz:
https://doaj.org/article/67ed2463e18d49fc9638e7762e1de9a6
Autor:
Derek Wong, Maha Tageldein, Ping Luo, Erik Ensminger, Jeffrey Bruce, Leslie Oldfield, Haifan Gong, Nicholas William Fischer, Brianne Laverty, Vallijah Subasri, Scott Davidson, Reem Khan, Anita Villani, Adam Shlien, Raymond H. Kim, David Malkin, Trevor J. Pugh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Germline pathogenic TP53 variants predispose individuals to a high lifetime risk of developing multiple cancers and are the hallmark feature of Li-Fraumeni syndrome (LFS). Our group has previously shown that LFS patients harbor shorter plasm
Externí odkaz:
https://doaj.org/article/91f463f696dc4e2f80c0b454ddff5916
Autor:
Alan J. Sosa, Michael K. Rooney, Howard D. Thames, Jeremiah W. Sanders, David M. Swanson, Seungtaek L. Choi, Quynh-Nhu Nguyen, Henry Mok, Deborah A. Kuban, X. Ron Zhu, Shalin Shah, Lauren L. Mayo, Karen E. Hoffman, Chad Tang, Sean E. McGuire, Narayan Sahoo, Xiaodong Zhang, Andrew K. Lee, Thomas J. Pugh, Usama Mahmood, John W. Davis, Brian F. Chapin, Paul Corn, Reena Kudchadker, Noveen Ausat, Steven J. Frank
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 48, Iss , Pp 100822- (2024)
Background: Proton therapy (PT) has unique biologic properties with excellent clinical outcomes for the management of localized prostate cancer. Here, we aim to characterize the toxicity of PT for patients with localized prostate cancer and propose m
Externí odkaz:
https://doaj.org/article/91f77869f0f94ffda164c4d00a789e7e
Autor:
J. Pugh
Publikováno v:
Pirineos: Revista de Ecología de Montaña, Vol 163, Pp 63-75 (2008)
Este artículo analiza críticamente las relaciones entre la escasez de recursos naturales, los conflictos, y la transformación del medio ambiente. Propone varias herramientas conceptuales que ofrecen una explicación detallada de la transformación
Externí odkaz:
https://doaj.org/article/d95774aac0e1423c9b98206e71c06448
Autor:
Jie Li, Christopher R. Chin, Hsia-Yuan Ying, Cem Meydan, Matthew R. Teater, Min Xia, Pedro Farinha, Katsuyoshi Takata, Chi-Shuen Chu, Yiyue Jiang, Jenna Eagles, Verena Passerini, Zhanyun Tang, Martin A. Rivas, Oliver Weigert, Trevor J. Pugh, Amy Chadburn, Christian Steidl, David W. Scott, Robert G. Roeder, Christopher E. Mason, Roberta Zappasodi, Wendy Béguelin, Ari M. Melnick
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Despite regulating overlapping gene enhancers and pathways, CREBBP and KMT2D mutations recurrently co-occur in germinal center (GC) B cell-derived lymphomas, suggesting potential oncogenic cooperation. Herein, we report that combined haploin
Externí odkaz:
https://doaj.org/article/a274f96f577b412184a054e29a28c213
Autor:
V. J. Forster, M. Aronson, C. Zhang, J. Chung, S. Sudhaman, M. A. Galati, J. Kelly, L. Negm, A. B. Ercan, L. Stengs, C. Durno, M. Edwards, M. Komosa, L. E. Oldfield, N. M. Nunes, S. Pedersen, J. Wellum, I. Siddiqui, V. Bianchi, B. R. Weil, V. L. Fox, T. J. Pugh, J. Kamihara, U. Tabori
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-7 (2024)
Abstract We report a case of Mismatch Repair Deficiency (MMRD) caused by germline homozygous EPCAM deletion leading to tissue-specific loss of MSH2. Through the use of patient-derived cells and organoid technologies, we performed stepwise in vitro di
Externí odkaz:
https://doaj.org/article/c5ab00ea2fb84351b0f60ec569862b24
Autor:
Scott C. Lien, Dalam Ly, S. Y. Cindy Yang, Ben X. Wang, Derek L. Clouthier, Michael St. Paul, Ramy Gadalla, Babak Noamani, Carlos R. Garcia-Batres, Sarah Boross-Harmer, Philippe L. Bedard, Trevor J. Pugh, Anna Spreafico, Naoto Hirano, Albiruni R. A. Razak, Pamela S. Ohashi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Immunotherapies targeting PD-1/PD-L1 are now widely used in the clinic to treat a variety of malignancies. While most of the research on T cell exhaustion and PD-1 blockade has been focused on conventional αβ T cells, the contribution of i
Externí odkaz:
https://doaj.org/article/fd59752fa86742a8a6eab34aa0b37b3b
Autor:
Alberto Hernando-Calvo, Paul Nguyen, Philippe L. Bedard, Kelvin K.W. Chan, Ramy R. Saleh, Deirdre Weymann, Celeste Yu, Eitan Amir, Dean A. Regier, Bishal Gyawali, Danielle Kain, Brooke Wilson, Craig C. Earle, Nicole Mittmann, Albiruni R. Abdul Razak, Wanrudee Isaranuwatchai, Peter Sabatini, Anna Spreafico, Tracy L. Stockley, Trevor J. Pugh, Christine Williams, Lillian L. Siu, Timothy P. Hanna
Publikováno v:
EClinicalMedicine, Vol 69, Iss , Pp 102443- (2024)
Summary: Background: To date, economic analyses of tissue-based next generation sequencing genomic profiling (NGS) for advanced solid tumors have typically required models with assumptions, with little real-world evidence on overall survival (OS), cl
Externí odkaz:
https://doaj.org/article/19ab2f66fed24a75a727e76111c21e84
Autor:
Kevin J. Pugh
Of all the topics ever studied, surely one of the most compelling is human learning itself. What is the nature of the human mind? How do we understand and process new information? Where do new ideas come from? How is our very intelligence a product o
Autor:
Panagiota A. Chousou, Rahul K. Chattopadhyay, Gareth D. K. Matthews, Vassilios S. Vassiliou, Peter J. Pugh
Publikováno v:
Diagnostics, Vol 14, Iss 3, p 299 (2024)
Introduction: Cardiac resynchronisation therapy is ineffective in 30–40% of patients with heart failure with reduced ejection fraction. Targeting non-scarred myocardium by selecting the site of latest mechanical activation using echocardiography ha
Externí odkaz:
https://doaj.org/article/c93a98acbf0e4633afc4a8f8cd7249d3