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Abstract P045: LUMINOS-103: A basket trial evaluating the safety and efficacy of PVSRIPO and PVSRIPO in combination with anti-PD-1/L1 checkpoint inhibitors in patients with advanced solid tumors

Autor: Brant A. Inman, Matthew I. Milowsky, Raj S. Pruthi, Marshall Posner, Melissa J. Polasek, Shannon R. Morris, Lori Mixson, Kristin Orr, Elizabeth M. H. Woodson, Andrea T. Kelly, W. Garrett Nichols, Arjun V. Balar

Publikováno v: Molecular Cancer Therapeutics. 20:P045-P045

Background: PVSRIPO, a novel intratumoral viral immunotherapy, infects cells via CD155, which is widely expressed on solid tumors and antigen-presenting cells (APC). Infection is lethal in malignant cells, but a unique, activating, nonlethal infectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::daa5ff2fa850f82192e5d7332b405bdd
https://doi.org/10.1158/1535-7163.targ-21-p045

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517 LUMINOS-103: a basket trial evaluating the safety and efficacy of PVSRIPO and PVSRIPO in combination with anti-PD-1/L1 checkpoint inhibitors in patients with advanced solid tumors

Autor: Brant A. Inman, Raj S. Pruthi, Andrea Kelly, Kristin Orr, Lori Mixson, Elizabeth M. H. Woodson, Matthew I. Milowsky, Shannon R. Morris, Arjun Vasant Balar, Melissa J. Polasek, Marshall R. Posner, Garrett Nichols

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundPVSRIPO, a novel intratumoral viral immunotherapy, infects cells via CD155, which is widely expressed on solid tumors and antigen-presenting cells (APC). Infection is lethal in malignant cells, but a unique, activating, nonlethal infection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e67599131359767f65468132ee87c16
https://doi.org/10.1136/jitc-2021-sitc2021.517

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P072 The Association Between Snoring and Hearing Loss in Patients with Obstructive Sleep Apnoea

Autor: A Fon, E Lawton, K Hobart, J Polasek, M Jurisevic

Publikováno v: SLEEP Advances. 2:A44-A44

Background Snoring is the commonest symptom of OSA, occurring in 70%-95% of patients. Snoring noise in severe OSA can reach, and exceed, peaks of 80 decibels(dB). This is a noise level at which permanent hearing loss can occur. Given the chronicity o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1003352131f7e059cbc86c17b9a5fa23
https://doi.org/10.1093/sleepadvances/zpab014.116

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Abstract CT242: LUMINOS-103: A basket trial evaluating the safety and efficacy of PVSRIPO in patients with advanced solid tumors

Autor: Shannon R. Morris, Lori Mixson, Andrea Kelly, Matthew I. Milowsky, Elizabeth M. Woodson, Melissa J. Polasek, Brant A. Inman, Raj S. Pruthi, Garrett Nichols, Arjun Vasant Balar, Kristin Orr

Publikováno v: Cancer Research. 81:CT242-CT242

Background: The recombinant poliovirus (PV):rhinovirus chimera, PVSRIPO, is a novel non-neurovirulent, intratumoral (IT) immunotherapy showing promising clinical activity in patients (pts) with recurrent glioblastoma and advanced anti-PD-1 refractory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4aa252bf8f07352d4c0f0023c3dd4f59
https://doi.org/10.1158/1538-7445.am2021-ct242

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Clinical Outcomes and Sustainability of Using CYP2C19 Genotype–Guided Antiplatelet Therapy After Percutaneous Coronary Intervention

Autor: Melissa J. Polasek, Shivanshu Madan, Kasey Hamrick, Vindhya B. Sriramoju, Jonathan D. Cicci, Megan Clarke, Lucius A. Howell, Craig R. Lee, Alexandra Cervantes, Nicholas Varunok, George A. Stouffer, Karen E. Weck, John Andrew Lee

Publikováno v: Circulation: Genomic and Precision Medicine. 11

Background: CYP2C19 loss-of-function (LOF) alleles impair clopidogrel effectiveness after percutaneous coronary intervention. The feasibility, sustainability, and clinical impact of using CYP2C19 genotype–guided dual antiplatelet therapy (DAPT) sel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff5ff0c4bf8ba6594ab4385524a855d
https://doi.org/10.1161/circgen.117.002069

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Review of clopidogrel dose escalation in the current era of potent P2Y12 inhibitors

Autor: George A. Stouffer, Joseph S. Rossi, Melissa J. Polasek, Lucius A. Howell

Publikováno v: Expert Review of Clinical Pharmacology. 8:411-421

Dual anti-platelet therapy with aspirin and a P2Y12 inhibitor is the standard of care for patients with acute coronary syndromes (ACS) and for patients undergoing percutaneous coronary intervention (PCI). Clopidogrel is associated with increased risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40190ed07edb01e397db5d4d1d99a331
https://doi.org/10.1586/17512433.2015.1057571

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Implementation and evaluation of a CYP2C19 genotype-guided antiplatelet therapy algorithm in high-risk coronary artery disease patients

Autor: John Andrew Lee, Craig R. Lee, George A. Stouffer, Karen E. Weck, Lucius A. Howell, Kristen E Tasca, Joseph S. Rossi, Melissa J. Polasek, Jonathan D. Cicci, David C. Plitt, Brent N. Reed

Publikováno v: Pharmacogenomics. 16:303-313

Aim: An algorithm that uses clinical factors and CYP2C19 genotype to guide P2Y12 inhibitor selection in high-risk patients undergoing percutaneous coronary intervention was implemented at our institution. We sought to evaluate use of this algorithm a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2dc7038628f9349953d3991f6c68a2
https://doi.org/10.2217/pgs.14.180

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CYP2C19-guided antiplatelet therapy: a cost-effectiveness analysis of 30-day and 1-year outcomes following percutaneous coronary intervention

Autor: Joel F. Farley, Olivia M. Dong, Mrudula S. Borse, Craig R. Lee, George A. Stouffer, Melissa J. Polasek

Publikováno v: Pharmacogenomics. 18(12)

Aim: Determine whether using CYP2C19 genotype to optimize antiplatelet therapy selection is cost effective over the initial 30 days and 1-year following percutaneous coronary intervention. Materials & methods: A cost–effectiveness analysis compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb3795e18f15841153b413f5ec2c85c
https://pubmed.ncbi.nlm.nih.gov/28745582

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Akademický článek

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Gesundheitsbezogene Lebensqualität

Autor: W. Manert, Josef Briegel, A. Lenhart, Mathias Haller, Gustav Schelling, M Heyduck, T. Hummel, Christian Stoll, M. Meier, M. Bullinger, J. Polasek

Publikováno v: Der Anaesthesist. 47:24-29

Einfuhrung und Methodik: Die extrakorporale Membranoxigenation (ECMO) zur Behandlung des schweren ARDS beim Erwachsenen ist eine aufwendige und teure Methode und in Einzelfallen lebensrettend. Es existieren jedoch keine Daten zur gesundheitsbezogenen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7cbd7ba663dce2fd6f1ddf9e8eebc966
https://doi.org/10.1007/s001010050518

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