Zobrazeno 1 - 10
of 2 039
pro vyhledávání: '"J. Platt"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Genetic testing in nephrotic syndrome may identify heterozygous predicted-pathogenic variants (HPPVs) in autosomal recessive (AR) genes that are known to cause disease in the homozygous or compound heterozygous state. In such cases, it can b
Externí odkaz:
https://doaj.org/article/35b038c0114144deb7cedc155869d01c
Publikováno v:
Journal of the California Dental Association, Vol 52, Iss 1 (2024)
ABSTRACTOn November 8, 2016, the citizens of Oakland enacted an initiative imposing a tax on sugar-sweetened beverages (SSBs). The passage was the culmination of interdisciplinary efforts, including critical support from the local dental society, as
Externí odkaz:
https://doaj.org/article/66c3777e4225433ba5bb8502827235ff
Publikováno v:
Journal of the California Dental Association, Vol 52, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/5f3dc13418ad406e87ac790888205fbe
Autor:
Avinash Aujayeb, Rachel Prichard, S Park, Mark A Baxter, J Hamilton, H Ali, L Hannington, Conor O'Neill, J Platt, G Clements, Deborah Scott, R Heywood, Helen Dearden, Sally Martin, Michael Rowe, Kieran Zucker, Clair Brunner, Adam L Peters, Maria Rohan, Alexandra Marsh, Abigail L Gee, Gemma Quesne, Jonny Heseltine, Joni Howells, Veronica Conteh, Xiangfei Yan, Lisa J Rodgers, J Grech, S McInerney, S Kingdon, L Eastlake, R Bryce, D Parslow, V Cope, N Aziz
Publikováno v:
BMJ Oncology, Vol 3, Iss 1 (2024)
Objective The Cancer and Aging Research Group (CARG) score was developed to predict severe chemotherapy-induced toxicity risk in older adults; validation study results have varied. The Tolerance of Anti-cancer Systemic Therapy in the Elderly study so
Externí odkaz:
https://doaj.org/article/30744de9a2794c768c87e2ba9b482a00
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Molecular screens comparing different disease states to identify candidate genes rely on the availability of fast, reliable and multiplexable systems to interrogate genes of interest. CRISPR/Cas9-based reverse genetics is a promising method
Externí odkaz:
https://doaj.org/article/7fd74c1a9e8f44f68884782a4b513558
Publikováno v:
eLife, Vol 10 (2021)
Class A G-protein-coupled receptors (GPCRs) normally function as monomers, although evidence from heterologous expression systems suggests that they may sometimes form homodimers and/or heterodimers. This study aims to evaluate possible functional in
Externí odkaz:
https://doaj.org/article/20dbf07498384c35b243ba1bdb96de64
Autor:
Jonathan J. Miner, Derek J. Platt, Cyrus M. Ghaznavi, Pallavi Chandra, Andrea Santeford, Amber M. Menos, Zhenyu Dong, Erin R. Wang, Wei Qian, Elysse S. Karozichian, Jennifer A. Philips, Rajendra S. Apte
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108339- (2020)
Summary: Here, we report our studies of immune-mediated regulation of Zika virus (ZIKV), herpes simplex virus 1 (HSV-1), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the human cornea. We find that ZIKV can be transmit
Externí odkaz:
https://doaj.org/article/1d747a51c2e3423d93390f3b6d7ce502
Autor:
Brock G. Bennion, Carys A. Croft, Teresa L. Ai, Wei Qian, Amber M. Menos, Cathrine A. Miner, Marie-Louis Frémond, Jean-Marc Doisne, Prabhakar S. Andhey, Derek J. Platt, Jennifer K. Bando, Erin R. Wang, Hella Luksch, Thierry J. Molina, Elisha D.O. Roberson, Maxim N. Artyomov, Angela Rösen-Wolff, Marco Colonna, Frédéric Rieux-Laucat, James P. Di Santo, Bénédicte Neven, Jonathan J. Miner
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107771- (2020)
Summary: STING gain-of-function causes autoimmunity and immunodeficiency in mice and STING-associated vasculopathy with onset in infancy (SAVI) in humans. Here, we report that STING gain-of-function in mice prevents development of lymph nodes and Pey
Externí odkaz:
https://doaj.org/article/f1e6b14586b644339c225d5a7c1cd1ea
Publikováno v:
eLife, Vol 9 (2020)
Synaptodendritic pruning is a common cause of cognitive decline in neurological disorders, including HIV-associated neurocognitive disorders (HAND). HAND persists in treated patients as a result of chronic inflammation and low-level expression of vir
Externí odkaz:
https://doaj.org/article/3b5f7f7602cd410bb2d8ece82693d122
