Overlay databank unlocks data-driven analyses of biomolecules for all

Autor: Anne M. Kiirikki, Hanne S. Antila, Lara S. Bort, Pavel Buslaev, Fernando Favela-Rosales, Tiago Mendes Ferreira, Patrick F. J. Fuchs, Rebeca Garcia-Fandino, Ivan Gushchin, Batuhan Kav, Norbert Kučerka, Patrik Kula, Milla Kurki, Alexander Kuzmin, Anusha Lalitha, Fabio Lolicato, Jesper J. Madsen, Markus S. Miettinen, Cedric Mingham, Luca Monticelli, Ricky Nencini, Alexey M. Nesterenko, Thomas J. Piggot, Ángel Piñeiro, Nathalie Reuter, Suman Samantray, Fabián Suárez-Lestón, Reza Talandashti, O. H. Samuli Ollila

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Tools based on artificial intelligence (AI) are currently revolutionising many fields, yet their applications are often limited by the lack of suitable training data in programmatically accessible format. Here we propose an effective solutio

Externí odkaz: https://doaj.org/article/acfa193917a24cbab8ffde269f7d7c0d

Dynamics of Crowded Vesicles: Local and Global Responses to Membrane Composition.

Autor: Daniel A Holdbrook, Roland G Huber, Thomas J Piggot, Peter J Bond, Syma Khalid

Publikováno v: PLoS ONE, Vol 11, Iss 6, p e0156963 (2016)

The bacterial cell envelope is composed of a mixture of different lipids and proteins, making it an inherently complex organelle. The interactions between integral membrane proteins and lipids are crucial for their respective spatial localization wit

Externí odkaz: https://doaj.org/article/4cfdf16ae40b4305a5cf9c66318322d2

Inverse Conformational Selection in Lipid–Protein Binding

Autor: Matti Javanainen, Salla I. Virtanen, Fernando Favela-Rosales, Chris Papadopoulos, Antonio Peón, Amélie Bacle, Anne M. Kiirikki, Patrick F.J. Fuchs, O. H. Samuli Ollila, Pavel Buslaev, Ángel Piñeiro, Rebeca García-Fandiño, Paula Milán Rodríguez, Tiago Mendes Ferreira, Markus S. Miettinen, Jesper J. Madsen, Josef Melcr, Ivan Gushchin, Thomas J. Piggot

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, 2021, 143 (34), pp.13701-13709. ⟨10.1021/jacs.1c05549⟩
Journal of the American Chemical Society, 143(34), 13701-13709. AMER CHEMICAL SOC
Journal of the American Chemical Society, American Chemical Society, 2021, 143 (34), pp.13701-13709. ⟨10.1021/jacs.1c05549⟩

International audience; Interest in lipid interactions with proteins and other biomolecules is emerging not only in fundamental biochemistry but also in the field of nanobiotechnology where lipids are commonly used, for example, in carriers of mRNA v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d9345531ed2d3d157ba5bfda9d2f8b
https://hal.sorbonne-universite.fr/hal-03355166/file/jacs.1c05549.pdf

Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system

Autor: Peter J. Wotherspoon, Christopher J. Harding, Gareth W. Hughes, Yasin Yakub, Jack A. Bryant, Mohammed Jamshad, Pooja Sridhar, Damon Huber, Andrew L. Lovering, Aneika C. Leney, Luke A. Clifton, Vaclav Spana, Rebecca J. Parr, Amirul H. Mahadi, Stephen Hall, Georgia L. Isom, Claire S. Laxton, Douglas G. Ward, Ian R. Henderson, Timothy J. Knowles, Mark Jeeves, Caitlin Hatton, Thomas J. Piggot, Ian T. Cadby

Publikováno v: Nature Microbiology. 4:1692-1705

The Mla pathway is believed to be involved in maintaining the asymmetrical Gram-negative outer membrane via retrograde phospholipid transport. The pathway is composed of three components: the outer membrane MlaA-OmpC/F complex, a soluble periplasmic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7ca874e392769f594e10b0ee8c93cb5
https://doi.org/10.1038/s41564-019-0481-y

Structural correlates of human muscle nicotinic acetylcholine receptor subunit assembly mediated by δ(+) interface residues

Autor: Max Epstein, Thomas J. Piggot, David Beeson, Isabel Bermudez, Susan Maxwell, Philip C. Biggin

Muscle nicotinic acetylcholine receptors are a class of heteropentameric ligand-gated cation channels with constituent subunits adopting a fixed stoichiometric arrangement. The specific amino acid residues that govern subunit ordering are however, on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8afe53b9b7fb2f2c9a4ee5e3527a12e0
https://doi.org/10.1101/2020.06.11.145466