Zobrazeno 1 - 10
of 421
pro vyhledávání: '"J. Pestka"'
Autor:
Lauren K. Heine, Lichchavi D. Rajasinghe, James G. Wagner, Ryan P. Lewandowski, Quan-Zhen Li, Alexa L. Richardson, Ashleigh N. Tindle, Jenan J. Shareef, Jack R. Harkema, James J. Pestka
Publikováno v:
Autoimmunity, Vol 57, Iss 1 (2024)
Lupus, a systemic autoimmune disease shaped by gene-environment interplay, often progresses to endstage renal failure. While subchronic systemic exposure to bacterial lipopolysaccharide (LPS) triggers autoimmunity and glomerulonephritis in lupus-pron
Externí odkaz:
https://doaj.org/article/24dd03243e4e46369e01de89b45b93c9
Autor:
Preeti S. Chauhan, Abby D. Benninghoff, Olivia K. Favor, James G. Wagner, Ryan P. Lewandowski, Lichchavi D. Rajasinghe, Quan-Zhen Li, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionWorkplace exposure to respirable crystalline silica (cSiO2) has been epidemiologically linked to lupus. Consistent with this, repeated subchronic intranasal cSiO2 instillation in lupus-prone NZBWF1 mice induces inflammation-/autoimmune-re
Externí odkaz:
https://doaj.org/article/1e54e2a2b11e4dc2b1e9f441abbd8a28
Autor:
Olivia K. Favor, Lichchavi D. Rajasinghe, Kathryn A. Wierenga, Krishna R. Maddipati, Kin Sing Stephen Lee, Andrew J. Olive, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPhagocytosis of inhaled crystalline silica (cSiO2) particles by tissue-resident alveolar macrophages (AMs) initiates generation of proinflammatory eicosanoids derived from the ω-6 polyunsaturated fatty acid (PUFA) arachidonic acid (ARA)
Externí odkaz:
https://doaj.org/article/c5241d8c3bfb4c839104b3a15452ac10
Autor:
Olivia K. Favor, Preeti S. Chauhan, Elham Pourmand, Angel M. Edwards, James G. Wagner, Ryan P. Lewandowski, Lauren K. Heine, Jack R. Harkema, Kin Sing Stephen Lee, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionLipopolysaccharide (LPS)-accelerated autoimmune glomerulonephritis (GN) in NZBWF1 mice is a preclinical model potentially applicable for investigating lipidome-modulating interventions against lupus. LPS can be expressed as one of two che
Externí odkaz:
https://doaj.org/article/833e51e1555d4f3481899efdb941de51
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Preclinical and clinical studies suggest that consumption of long chain omega-3 polyunsaturated fatty acids (PUFAs) reduces severity of chronic inflammatory and autoimmune diseases. While these ameliorative effects are conventionally associated with
Externí odkaz:
https://doaj.org/article/2eecaa6caa584fbe8a662f3e8e3044eb
Autor:
Lauren K. Heine, Abby D. Benninghoff, Elizabeth A. Ross, Lichchavi D. Rajasinghe, James G. Wagner, Ryan P. Lewandowski, Alexa L. Richardson, Quan-Zhen Li, John P. Buchweitz, Justin Zyskowski, Ashleigh N. Tindle, Anna E. Skedel, Nicholas J. Chargo, Laura R. McCabe, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Autoimmune diseases can be triggered by environmental toxicants such as crystalline silica dust (cSiO2). Here, we characterized the dose-dependent immunomodulation and toxicity of the glucocorticoid (GC) prednisone in a preclinical model that emulate
Externí odkaz:
https://doaj.org/article/9d62c3f710e94b838f4b340305d3c650
Autor:
Lichchavi D. Rajasinghe, Quan-Zhen Li, Chengsong Zhu, Mei Yan, Preeti S. Chauhan, Kathryn A. Wierenga, Melissa A. Bates, Jack R. Harkema, Abby D. Benninghoff, James J. Pestka
Publikováno v:
Autoimmunity, Vol 53, Iss 7, Pp 415-433 (2020)
Inhalation of crystalline silica (cSiO2) in the workplace is etiologically linked to lupus and other autoimmune diseases. Exposing lupus-prone NZBWF1 mice to respirable cSiO2 unleashes a vicious cycle of inflammation and cell death in the lung that t
Externí odkaz:
https://doaj.org/article/88c45cb13ba94771ace3f1fe7e918ae4
Autor:
Lichchavi D. Rajasinghe, Melissa A. Bates, Abby D. Benninghoff, Kathryn A. Wierenga, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Repeated short-term intranasal instillation of lupus-prone mice with crystalline silica (cSiO2) induces inflammatory gene expression and ectopic lymphoid neogenesis in the lung, leading to early onset of systemic autoimmunity and rapid progression to
Externí odkaz:
https://doaj.org/article/1b39b5825b9f4754b52009ab265ddf9b
Publikováno v:
Frontiers in Toxicology, Vol 3 (2021)
Exposure to exogenous particles found as airborne contaminants or endogenous particles that form by crystallization of certain nutrients can activate inflammatory pathways and potentially accelerate autoimmunity onset and progression in genetically p
Externí odkaz:
https://doaj.org/article/55e5c7e59e9f484fa950481215ed62a6
Autor:
James J. Pestka, Peyman Akbari, Kathryn A. Wierenga, Melissa A. Bates, Kristen. N. Gilley, James G. Wagner, Ryan P. Lewandowski, Lichchavi D. Rajasinghe, Preeti S. Chauhan, Adam L. Lock, Quan-Zhen Li, Jack R. Harkema
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Workplace exposure to respirable crystalline silica dust (cSiO2) has been etiologically linked to the development of lupus and other human autoimmune diseases. Lupus triggering can be recapitulated in female NZBWF1 mice by four weekly intranasal inst
Externí odkaz:
https://doaj.org/article/90c7bbdff77a4cfdaf46a31f0c11d679