Zobrazeno 1 - 10
of 34
pro vyhledávání: '"J. Perry Hall"'
Autor:
Diane L. Rosin, J. Perry Hall, Shuqiu Zheng, Liping Huang, Silvia Campos-Bilderback, Ruben Sandoval, Andrea Bree, Kevin Beaumont, Emily Miller, Jennifer Larsen, Ghazal Hariri, Neelu Kaila, Iain M. Encarnacion, Jeremy D. Gale, Andrea van Elsas, Bruce A. Molitoris, Mark D. Okusa
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Adenosine triphosphate (ATP) released from injured or dying cells is a potent pro-inflammatory “danger” signal. Alkaline phosphatase (AP), an endogenous enzyme that de-phosphorylates extracellular ATP, likely plays an anti-inflammatory role in im
Externí odkaz:
https://doaj.org/article/8a48422a8c3f4fea9d0b25430207d3fe
Autor:
J. Perry Hall, Angela Hadjipanayis, Yogeshwar Kelkar, Stefanie Y. Tan, Thomas A. Wynn, Arun Shipstone
Publikováno v:
The Journal of Immunology. 205:957-967
Metabolic reprogramming plays a central role in T cell activation and differentiation, and the inhibition of key metabolic pathways in activated T cells represents a logical approach for the development of new therapeutic agents for treating autoimmu
Autor:
Stefanie Y, Tan, Yogeshwar, Kelkar, Angela, Hadjipanayis, Arun, Shipstone, Thomas A, Wynn, J Perry, Hall
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 205(4)
Metabolic reprogramming plays a central role in T cell activation and differentiation, and the inhibition of key metabolic pathways in activated T cells represents a logical approach for the development of new therapeutic agents for treating autoimmu
Autor:
Aiping Jiao, Julia A. Guzova, Chiachin Lee, Michael J. Primiano, Aaron Winkler, J. Perry Hall, Jeffrey L. Stock
Publikováno v:
Journal of immunological methods. 467
The NLRP3 inflammasome is a complex multimeric signaling apparatus that regulates production of the pro-inflammatory cytokine IL-1β. To overcome both the variability among primary immune cells and the limitations of genetic manipulation of different
Autor:
Katherine J. Seidl, J. Perry Hall, Paulina Wochal, Luke A. J. O'Neill, Aisling Dunne, Lih-Ling Lin, Vijay A. K. Rathinam, Wen Kuang, Thaddeus Carlson, Caio T. Fagundes, Christopher R. MacKay, Mary Collins, Susan Carpenter, Stefan A. Schattgen, Katherine A. Fitzgerald
Publikováno v:
The Journal of Immunology. 193:1911-1919
TLR4 interactor with leucine-rich repeats (TRIL) is a brain-enriched accessory protein that is important in TLR3 and TLR4 signaling. In this study, we generated Tril−/− mice and examined TLR responses in vitro and in vivo. We found a role for TRI
Autor:
J. Perry Hall, Michael J. Primiano, Aaron Winkler, Aiping Jiao, Chiachin Lee, Jeffrey L. Stock, Julia A. Guzova
Publikováno v:
Journal of Immunological Methods. 468:67
Autor:
Isis Ludwig-Portugall, Christian Kurts, Peter Boor, Beatrix D.G. Evers, Eva Bartok, Bernardo S. Franklin, Veit Hornung, Michael J. Primiano, J. Perry Hall, Percy A. Knolle, Ermanila Dhana, Eicke Latz, Gunther Hartmann
Publikováno v:
Kidney international. 90(3)
Intrarenal crystal formation activates the Nlrp3 inflammasome in myeloid cells and triggers a profound inflammatory response. Here, we studied whether a specific inhibitor of the Nlrp3 inflammasome, CP-456,773, can prevent kidney fibrosis in a murine
Autor:
Michael J. Primiano, Andrea G Bree, Paul D. Bonin, Aiping Jiao, Stephen W. J. Wang, J. Perry Hall, David Hepworth, Ken Dower, Julia A. Guzova, Bruce Allen Lefker, Cedric Hubeau, Eicke Latz, Leah Cushing, Brian G. Monks, Lih-Ling Lin, Michael R. Bowman, Matthew Mangan
Publikováno v:
The journal of immunology 197(6), 2421-2433 (2016). doi:10.4049/jimmunol.1600035
A critical component of innate immune response to infection and tissue damage is the NACHT, LRR, and PYD domains–containing protein 3 (NLRP3) inflammasome, and this pathway and its activation products have been implicated in the pathophysiology of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a45da7ad6fb5bbbb12a62c5ee3ad0b
Autor:
G. Roger Askew, Tianhui Zhou, Victoria Roberts, Katherine A. Fitzgerald, Lih-Ling Lin, Suzana Marusic, Vincent Ling, J. Perry Hall, Nancy L. Stedman, Zhaozhao Jiang, Paresh Thakker, Mark Ryan, Erica Marchlik, Wen Kuang, Richard Pfeifer, Stephen C. Benoit, Nadege Goutagny, Thaddeus Carlson
Publikováno v:
Journal of Leukocyte Biology. 88:1171-1180
Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues, altered circulating immune cell compartments, and increased susceptibility to LPS-induced lethality. TBK1 is critical for immunity against microbial pathogens that activa
Autor:
Rajeev Hotchandani, Neal Jeffrey Green, Junqing Cui, Suzana Marusic, Wei Li, Yonghan Hu, Neelu Kaila, J. Perry Hall, Tam Steve Yik-Kai, Lih-Ling Lin, Jeffrey W. Pelker, Sang Hsu, Huan-Qiu Li, Adrian Huang, Jeffrey Scott Condon, Qin Wang, Jean-Baptiste Telliez, Junjun Wu, Satenig Guler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3485-3488
Tpl2 (cot/MAP3K8) is an upstream kinase of MEK in the ERK pathway. It plays an important role in Tumor Necrosis Factor-alpha (TNF-alpha) production and signaling. We have discovered that 8-halo-4-(3-chloro-4-fluoro-phenylamino)-6-[(1H-[1,2,3]triazol-