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Akademický článek

Abuse potential of fentanyl and fentanyl analogues.

Autor: Thumma, Anusha¹ (AUTHOR), Mfoafo, Kwadwo¹ (AUTHOR), Babanejad, Niloofar¹ (AUTHOR), Omidian, Alborz² (AUTHOR), Omidi, Yadollah¹ (AUTHOR), Omidian, Hamid¹ (AUTHOR) omidian@nova.edu

Publikováno v: BioImpacts. Nov2024, Vol. 14 Issue 6, p1-16. 16p.

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Design, Synthesis, and Analysis of a Polyethelene Glycol-Modified (PEGylated) Small Molecule Inhibitor of Integrin α4β1 with Improved Pharmaceutical Properties

Autor: Mark Cornebise, C. Nickerson-Nutter, Brian M. Dolinski, Stuart J. Perper, Steve Adams, Alan Gill, Diane R Leone, Doreen Lepage, Keith Giza, R. B. Pepinsky, L. L. Chen, Eric T. Whalley, Roy R. Lobb, K. Wortham, Petter Russell C, Daniel Scott, Wen-Cherng Lee, A. Chakraborty

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 312:742-750

Integrin alpha4beta1 plays an important role in inflammatory processes by regulating the migration of leukocytes into inflamed tissues. Previously, we identified BIO5192 [2(S)-{[1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2(S)-carbonyl]-amino}-4-[4-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9daccf593e3e23af58b9231b1c686183
https://doi.org/10.1124/jpet.104.075648

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An Assessment of the Mechanistic Differences Between Two Integrin α4β1Inhibitors, the Monoclonal Antibody TA-2 and the Small Molecule BIO5192, in Rat Experimental Autoimmune Encephalomyelitis

Autor: Roy R. Lobb, Mark Cornebise, Russell C. Petter, C. Nickerson-Nutter, K. Wortham, Doreen Lepage, R. B. Pepinsky, Wen-Cherng Lee, Steve Adams, L. L. Chen, Daniel Scott, J. C. Spell, Brian M. Dolinski, Alan Gill, W. Yang, Keith Giza, Stuart J. Perper, Eric T. Whalley, Diane R Leone

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 305:1150-1162

Integrin alpha 4 beta 1 plays an important role in inflammatory processes by regulating the migration of lymphocytes into inflamed tissues. Here we evaluated the biochemical, pharmacological, and pharmacodynamic properties and efficacy in experimenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08a2c9025a531d25a49df899c5a776c
https://doi.org/10.1124/jpet.102.047332

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Akademický článek

The effect of long-pulsed 1064 nm Nd:YAG laser-assisted hair removal on some skin flora and pathogens: An in vivo study.

Autor: Elsaeed Eldeeb, Marwa (AUTHOR) marwa.eldeeb16@alexmed.edu.eg, El Mulla, Khaled (AUTHOR), Alshaer, Abeer (AUTHOR), Ashraf, Heba M.¹ (AUTHOR), Omran, Eman A.¹ (AUTHOR)

Publikováno v: Indian Journal of Dermatology, Venereology & Leprology. Sep/Oct2024, Vol. 90 Issue 5, p1-9. 9p.

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Anti-arthritic effects demonstrated by an interleukin-2 receptor-targeted cytotoxin (DAB486IL-2) in rat adjuvant arthritis

Autor: Patricia Bacha, Jean C. Nichols, David E. Trentham, Stuart J. Perper, Serene E. Forte

Publikováno v: European Journal of Immunology. 22:1673-1679

DAB486IL-2 is an interleukin-2 receptor-specific cytotoxin which selectively targets and kills cells which bear the high-affinity form of the IL-2 receptor. Since elimination of activated T lymphocytes may be useful in the treatment of rheumatoid art

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19dea7ec7665847bbc1911fd4a4baa16
https://doi.org/10.1002/eji.1830220702

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TWEAK is a novel arthritogenic mediator

Autor: Shawn Weng, Cindy Gao, Gerald J. Atkins, Timothy S. Zheng, Luis Rajman, Keith Giza, Stuart J. Perper, David M. Findlay, Thomas Crowell, Lihe Su, Leticia Tarilonte, Beth Browning, Linda C. Burkly, Laura Runkel, Henry Hess, Martin L. Scott

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 177(4)

TNF-like weak inducer of apoptosis (TWEAK) is a TNF family member with pleiotropic effects on a variety of cell types, one of which is the induction of proinflammatory cytokines by synovial fibroblasts derived from rheumatoid arthritis (RA) patients.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1187ce74ac7a63bfa3b5e6dfce11c96
https://pubmed.ncbi.nlm.nih.gov/16888023

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A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT

Autor: Cheryl Nickerson-Nutter, Irene Sizing, Jeffrey L. Browning, Stuart J. Perper, Apinya Ngam-ek, Jennifer L. Gommerman, Keith Giza

Publikováno v: The Journal of clinical investigation. 112(5)

In studies using genetically deficient mice, a role for the lymphotoxin (LT) system in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) has remained controversial. Here, we have reassessed this conclusion by using a fusion protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b70a1867fabee8c7a2d152477af9d343
https://pubmed.ncbi.nlm.nih.gov/12952924

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Differential effects of treatment with a small-molecule VLA-4 antagonist before and after onset of relapsing EAE

Autor: Cheryl Nickerson-Nutter, Bradley E. Theien, Eric T. Whalley, Carol L. Vanderlugt, Daniel Scott, Stuart J. Perper, Mark Cornebise, Stephen D. Miller

Publikováno v: Blood. 102(13)

Interaction of very late antigen-4 (VLA-4) with its ligand vascular cell adhesion molecule-1 (VCAM-1) is required for central nervous system (CNS) migration of encephalitogenic T cells in relapsing experimental autoimmune encephalomyelitis (R-EAE). A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1d2aa6bfed9ace52e82743ddfa9a78
https://pubmed.ncbi.nlm.nih.gov/12933585

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