Zobrazeno 1 - 10
of 174
pro vyhledávání: '"J. Pelham"'
Autor:
Fortunato Ciardiello, Yung‐Jue Bang, Andrés Cervantes, Mikhail Dvorkin, Charles D. Lopez, Jean‐Philippe Metges, Antonio Sánchez Ruiz, Mariona Calvo, Andrew H. Strickland, George Kannourakis, Kei Muro, Hisato Kawakami, Jia Wei, Christophe Borg, Zhaoyin Zhu, Neal Gupta, Robert J. Pelham, Lin Shen
Publikováno v:
Cancer Medicine, Vol 12, Iss 12, Pp 13145-13154 (2023)
Abstract Background Poly (ADP‐ribose) polymerase (PARP) inhibitors (PARPi) are approved for the treatment of various solid tumors. In gastric cancer, genes commonly harbor mutations in the homologous recombination DNA repair pathway, potentially in
Externí odkaz:
https://doaj.org/article/4b2f01f4e75d4aedaab63e873f6aa1b0
Autor:
Michail Yekelchyk, Esha Madan, Jochen Wilhelm, Kirsty R Short, António M Palma, Linbu Liao, Denise Camacho, Everlyne Nkadori, Michael T Winters, Emily S Rice, Inês Rolim, Raquel Cruz‐Duarte, Christopher J Pelham, Masaki Nagane, Kartik Gupta, Sahil Chaudhary, Thomas Braun, Raghavendra Pillappa, Mark S Parker, Thomas Menter, Matthias Matter, Jasmin Dionne Haslbauer, Markus Tolnay, Kornelia D Galior, Kristina A Matkwoskyj, Stephanie M McGregor, Laura K Muller, Emad A Rakha, Antonio Lopez‐Beltran, Ronny Drapkin, Maximilian Ackermann, Paul B Fisher, Steven R Grossman, Andrew K Godwin, Arutha Kulasinghe, Ivan Martinez, Clay B Marsh, Benjamin Tang, Max S Wicha, Kyoung Jae Won, Alexandar Tzankov, Eduardo Moreno, Rajan Gogna
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 11, Pp 1-17 (2021)
Abstract Risk stratification of COVID‐19 patients is essential for pandemic management. Changes in the cell fitness marker, hFwe‐Lose, can precede the host immune response to infection, potentially making such a biomarker an earlier triage tool.
Externí odkaz:
https://doaj.org/article/f8eb078fb27a469bb4350f69d131fd6a
Autor:
Simon J. Pelham, Maria Soledad Caldirola, Danielle T. Avery, Joseph Mackie, Geetha Rao, Florian Gothe, Timothy J. Peters, Antoine Guerin, David Neumann, Doris Vokurkova, Vivian Hwa, Wenming Zhang, Shu-Chen Lyu, Iris Chang, Monali Manohar, Kari C. Nadeau, Maria Isabel Gaillard, Liliana Bezrodnik, Violeta Iotova, Norberto Walter Zwirner, Mavel Gutierrez, Waleed Al-Herz, Christopher C. Goodnow, Alexander Vargas-Hernández, Lisa R. Forbes Satter, Sophie Hambleton, Elissa K. Deenick, Cindy S. Ma, Stuart G. Tangye
Publikováno v:
Journal of Allergy and Clinical Immunology. 150:931-946
Lymphocyte differentiation is regulated by coordinated actions of cytokines and signaling pathways. IL-21 activates STAT1, STAT3, and STAT5 and is fundamental for the differentiation of human B cells into memory cells and antibody-secreting cells. Wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f1417bb6e8b95ace14224a6883f8bb
https://doi.org/10.1016/j.jaci.2022.04.011
https://doi.org/10.1016/j.jaci.2022.04.011
Autor:
Braeden Donaldson, Farah Al-Barwani, Simon J. Pelham, Katie Young, Vernon K. Ward, Sarah L. Young
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-13 (2017)
Abstract Background Colorectal cancer is responsible for almost 700,000 deaths annually worldwide. Therapeutic vaccination is a promising alternative to conventional treatment for colorectal cancer, using vaccines to induce targeted immune responses
Externí odkaz:
https://doaj.org/article/cdf421eccad84ac082a2cee418327f0d
Publikováno v:
Epigenetics in Organ Specific Disorders ISBN: 9780128239315
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a30e6e14c1056c800e8b8ee5cb08282
https://doi.org/10.1016/b978-0-12-823931-5.00009-8
https://doi.org/10.1016/b978-0-12-823931-5.00009-8
Autor:
Paban K. Agrawala, Christopher Alvarado, Mohammed Amir, Ksenija Bernau, Aditi Bhattacharya, Biswajit Biswas, Megan Block, Anvitha Boosani, Chandra S. Boosani, Allan R. Brasier, Julia A. Brown, Rajasree Chakraborty, Abhijit Das, Nikhitha Dasari, Johanna K. DiStefano, B.S. Dwarakanath, Tohru Fukai, Anil Bhanudas Gaikwad, Fangyan Gong, Rosalba Gornati, Ritobrata Goswami, Palanikumar Gunasekar, Noopur Gupta, Ebrahim Bani Hassan, Gopal P. Jadhav, Natasha Victoria Jain, Fang Jiang, Wanlin Jiang, Jonathan Kreger, Yogesh A. Kulkarni, Patricia N. Le, Lei Liu, Jayant Maini, Papiya Mondal, Kenta Nakai, Umamaheswari Natarajan, Michael T. Olson, Christina Pagiatakis, Madhura R. Pandkar, Amit M. Pant, Roberto Papait, Srinivas Patnaik, Christopher J. Pelham, Anu Prakash, Appu Rathinavelu, Nathan Sandbo, Subhajit Sarkar, Ajay Sharma, Nisha Sharma, Vineeta Sharma, Niharika Shiva, Sanjeev Shukla, Lakshman Singh, Sukhveer Singh, Saurabh Singhal, Vikas Srivastava, Varadarajan Sudhahar, Céline Tiffon, Masuko Ushio-Fukai, Alexis Vandenbon, Judy Weng, Jesse Woo, Xiumei Wu, Pooja Yadav, Melody Y. Zeng
Publikováno v:
Epigenetics in Organ Specific Disorders ISBN: 9780128239315
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b7c6b2d58d0b9af9a066b8a109a3f57
https://doi.org/10.1016/b978-0-12-823931-5.09990-4
https://doi.org/10.1016/b978-0-12-823931-5.09990-4
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of many key cytokine receptors expressed by lymphocytes. As such, it plays a critical role in regulating B cells as well as CD4+ and CD8
Externí odkaz:
https://doaj.org/article/fa17f450d0104f4db658ee01d1bf2eaa
Autor:
Eser Kirkizlar, Bernhard Zimmermann, Tudor Constantin, Ryan Swenerton, Bin Hoang, Nicholas Wayham, Joshua E. Babiarz, Zachary Demko, Robert J. Pelham, Stephanie Kareht, Alexander L. Simon, Kristine N. Jinnett, Matthew Rabinowitz, Styrmir Sigurjonsson, Matthew Hill
Publikováno v:
Translational Oncology, Vol 8, Iss 5, Pp 407-416 (2015)
We demonstrate proof-of-concept for the use of massively multiplexed PCR and next-generation sequencing (mmPCR-NGS) to identify both clonal and subclonal copy-number variants (CNVs) in circulating tumor DNA. This is the first report of a targeted met
Externí odkaz:
https://doaj.org/article/7d066fbaf8d04bb1b6461ca5636564b1
Autor:
Masato Ogishi, Rui Yang, Rémy Rodriguez, Dominic P. Golec, Emmanuel Martin, Quentin Philippot, Jonathan Bohlen, Simon J. Pelham, Andrés Augusto Arias, Taushif Khan, Manar Ata, Fatima Al Ali, Flore Rozenberg, Xiao-Fei Kong, Maya Chrabieh, Candice Laine, Wei-Te Lei, Ji Eun Han, Yoann Seeleuthner, Zenia Kaul, Emmanuelle Jouanguy, Vivien Béziat, Leila Youssefian, Hassan Vahidnezhad, V. Koneti Rao, Bénédicte Neven, Claire Fieschi, Davood Mansouri, Mohammad Shahrooei, Sevgi Pekcan, Gulsum Alkan, Melike Emiroğlu, Hüseyin Tokgöz, Jouni Uitto, Fabian Hauck, Jacinta Bustamante, Laurent Abel, Sevgi Keles, Nima Parvaneh, Nico Marr, Pamela L. Schwartzberg, Sylvain Latour, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis
Publikováno v:
Journal of Experimental Medicine. 220
Inborn errors of IFN-γ immunity can underlie tuberculosis (TB). We report three patients from two kindreds without EBV viremia or disease but with severe TB and inherited complete ITK deficiency, a condition associated with severe EBV disease that r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df6e1dfbe7f7c13e89ffd1eb29a9719
https://doi.org/10.1084/jem.20220484
https://doi.org/10.1084/jem.20220484
Autor:
Nicholas Barasch, Xue Gong, Kevin A Kwei, Sushama Varma, Jewison Biscocho, Kunbin Qu, Nan Xiao, Joseph S Lipsick, Robert J Pelham, Robert B West, Jonathan R Pollack
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171265 (2017)
Pathogenic gene fusions have been identified in several histologic types of salivary gland neoplasia, but not previously in acinic cell carcinoma (AcCC). To discover novel gene fusions, we performed whole-transcriptome sequencing surveys of three AcC
Externí odkaz:
https://doaj.org/article/614af5fbee1a4ef991eedc4a5ab3af7a