Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis

Autor: Pedro Rafael Dimbu, Marit De Wit, Kamala L. Thriemer, Sarah G. Staedke, Filomeno Fortes, Salim Abdulla, Julie A. Simpson, Oliver James Pratt, Bart Janssens, Andreas Mårtensson, Veronique Sinou, Steffen Borrmann, Walter R. J. Taylor, Ingrid van der Broek, Christopher J. M. Whitty, Meghna Desai, François Bompart, Zulfikarali Premji, Theonest K. Mutabingwa, Aarti Agarwal, Anupkumar R. Anvikar, Emmanuel Arinaitwe, Petra F. Mens, Piero Olliaro, François Nosten, Maman Laminou Ibrahim, Birgit Schramm, Hasifa Bukirwa, Michèle van Vugt, Jane Achan, J. Pedro Gil, Timothy M. E. Davis, Ogobara K. Doumbo, Michel Cot, Grant Dorsey, Michael Ramharter, Sue J. Lee, Sodiomon B. Sirima, Ambrose O. Talisuna, Poul-Erik Kofoed, Brian Greenwood, Catherine O. Falade, Valerie Lameyre, Mayfong Mayxay, Andre Toure Offianan, Hervé Ei Menan, Teun Bousema, Erasmus Kamugisha, Chris J. Drakeley, Elizabeth Juma, Johan Ursing, Abul Faiz, Emmanuel Temu, Carol Hopkins Sibley, Patrice Piola, Philip J. Rosenthal, Frank Smithuis, Mateusz M. Plucinski, Marco Corsi, Anastasia Grivoyannis, Richard Allan, Elizabeth A. Ashley, Harald Noedl, Jean François Faucher, Issaka Zongo, Corine Karema, Cornelis Winnips, Kamal Hamed, Umberto D'Alessandro, Venkatachalam Udhayakumar, Michael D. Edstein, Fred Kironde, Harin Karunajeewa, Philippe Deloron, Quique Bassat, Patrick Sawa, David P. Hughes, Ishag Adam, Michel Van Herp, Christopher V. Plowe, Ghulam Rahim Awab, Caterina I. Fanello, Joel Tarning, Stephan Duparc, Jean Bosco Ouedraogo, Emmanuelle Espie, Tran Tinh Hien, Jean R. Kiechel, Anders Björkman, Abdoulaye Djimde, Billy E. Ngasala, Nahla B. Gadalla, Prabin Dahal, Kasia Stepniewska, Lars Rombo, Nhien Nguyen Thuy, Philippe J Guerin, Verena I. Carrara, Babacar Faye, Christophe Rogier, Peter G. Kremsner, Oumar Gaye, Inge Sutanto, Jean-Louis A Ndiaye, Bernhards Ogutu, Mary Oguike, Vincent Jullien, Jimee Hwang, Kevin Marsh, Djibrine Djalle, Ric N. Price, Yavo William, Georgina S Humphreys

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Malaria Journal, Vol 18, Iss 1, Pp 1-14 (2019)
Malaria Journal
Malaria Journal, BioMed Central, 2019, 18 (1), pp.225. ⟨10.1186/s12936-019-2837-4⟩
Recercat. Dipósit de la Recerca de Catalunya
instname
Malaria Journal, 2019, 18 (1), pp.225. ⟨10.1186/s12936-019-2837-4⟩
WorldWide Antimalarial Resistance Network Methodology Study Group & Kofoed, P-E 2019, ' Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria : a WorldWide Antimalarial Resistance Network individual participant data meta-analysis ', Malaria Journal, vol. 18, 225 . https://doi.org/10.1186/s12936-019-2837-4
Malaria journal, 18(1):225. BioMed Central

Background Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potentially preclude/pre-empt the detection of subsequent recrudescence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06241f543956292d16b67e8f79205394
http://hdl.handle.net/2445/139040

pfmdr1 (Plasmodium falciparum multidrug drug resistance gene 1): a pivotal factor in malaria resistance to artemisinin combination therapies

Autor: Sanjeev Krishna, J. Pedro Gil

Publikováno v: Expert review of anti-infective therapy. 15(6)

Plasmodium falciparum, the deadly agent of malaria, is notorious for its capacity to develop drug resistance. Treatment failures of artemisinin therapy regimens (ACTc), the present mainstay, is emerging. The transporter coding pfmdr1 gene is a centra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f285376accc4aa8856723de12e6caef0
https://pubmed.ncbi.nlm.nih.gov/28355493

The Vietnamese Khin Population Harbors Particular N-Acetyltransferase 2 Allele Frequencies

Autor: Pedro Eduardo Ferreira, M. Isabel Veiga, J. Pedro Gil, Isa Cavaco, Vera Ribeiro, Trinh Ngoc Hai, Myriam Peyrard-Janvid, Sara Asimus, Michael Ashton

Publikováno v: Clinical Chemistry. 53:1977-1979

Vietnam ranks 13th among the 23 countries that must deal with 80% of global deaths from tuberculosis (1). The National Tuberculosis Control Program of Vietnam implemented the WHO DOTS (directly observed therapy, short course) strategy in 1989. The st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c540efa674d6fb832f8d119be2f3642
https://doi.org/10.1373/clinchem.2007.092684

Plasmodium falciparum multidrug resistance protein 1 and artemisinin-based combination therapy in Africa

Autor: Akira Kaneko, Andreas Mårtensson, Christin Sisowath, Björn Andersson, Anna Färnert, Lyda Osorio, Sabina Dahlström, M. Isabel Veiga, J. Pedro Gil, Gwenaëlle Conseil, Hamid Darban, Nazli Sedighi, Pedro Eduardo Ferreira, Anders Björkman, Lisa Wiklund

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Plasmodium falciparum response mechanisms to the major artemisinin-based combination therapies (ACTs) are largely unknown. Multidrug-resistance protein (MRP)-like adenosine triphosphate (ATP)-binding cassette transporters are known to be related to m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed160d0e86e3871f6f9f9f7b15ce25cf

CYP2C8 polymorphism among the Portuguese

Autor: Vera Ribeiro, Isa Cavaco, J. Pedro Gil, Rita Piedade

Publikováno v: Clinical chemistry and laboratory medicine. 44(2)

Cytochrome P450 2C8 (CYP2C8) is a polymorphic phase I drug-metabolising enzyme involved in the metabolism of a wide variety of xenobiotics, as well as a proposed player in the regulation of vascular tone. Polymorphisms in this gene may have an impact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf1fde4cbdf1f2358574f82018407eb
https://pubmed.ncbi.nlm.nih.gov/16475901