Zobrazeno 1 - 10
of 409
pro vyhledávání: '"J. Pecaut"'
Characterization of gene expression profiles in the mouse brain after 35 days of spaceflight mission
Autor:
Jacob M. Holley, Seta Stanbouly, Michael J. Pecaut, Jeffrey S. Willey, Michael Delp, Xiao Wen Mao
Publikováno v:
npj Microgravity, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract It has been proposed that neuroinflammatory response plays an important role in the neurovascular remodeling in the brain after stress. The goal of the present study was to characterize changes in the gene expression profiles associated with
Externí odkaz:
https://doaj.org/article/fc38a452cfec4318834d8572d8d3e102
Autor:
Foluwasomi A Oyefeso, Gabriela Goldberg, Nana Yaa P S Opoku, Marcelo Vazquez, Antonella Bertucci, Zhong Chen, Charles Wang, Alysson R Muotri, Michael J Pecaut
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0282958 (2023)
Human exposure to low-to-moderate dose ionizing radiation (LMD-IR) is increasing via environmental, medical, occupational sources. Acute exposure to LMD-IR can cause subclinical damage to cells, resulting in altered gene expression and cellular funct
Externí odkaz:
https://doaj.org/article/fdd2d19a98bc4f9c95091abd53f6640a
Autor:
Amber M. Paul, Eliah G. Overbey, Willian A. da Silveira, Nathaniel Szewczyk, Nina C. Nishiyama, Michael J. Pecaut, Sulekha Anand, Jonathan M. Galazka, Xiao Wen Mao
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Using a ground-based model to simulate spaceflight [21-days of single-housed, hindlimb unloading (HLU) combined with continuous low-dose gamma irradiation (LDR, total dose of 0.04 Gy)], an in-depth survey of the immune and hematological syst
Externí odkaz:
https://doaj.org/article/91a26c1151db4a87aec85ba385b2cd84
Autor:
Alicia L. Veliz, Lana Mamoun, Lorelei Hughes, Richard Vega, Bailey Holmes, Andrea Monteon, Jillian Bray, Michael J. Pecaut, Mary Kearns-Jonker
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 371 (2023)
Efforts to understand the impact of spaceflight on the human body stem from growing interest in long-term space travel. Multiple organ systems are affected by microgravity and radiation, including the cardiovascular system. Previous transcriptomic st
Externí odkaz:
https://doaj.org/article/4f88689739904fdaae6037b6f434b7dc
Autor:
Trisha A Rettig, Bailey A Bye, Nina C Nishiyama, Savannah Hlavacek, Claire Ward, Michael J Pecaut, Stephen K Chapes
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210284 (2019)
Spaceflight affects the immune system, but the effects on the antibody repertoire, responsible for humoral immunity, has not been well explored. In particular, the complex gene assembly and expression process; including mutations, might make this pro
Externí odkaz:
https://doaj.org/article/29bb7291121a4eae9c89de2e8c698669
Akademický článek
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Autor:
Foluwasomi A. Oyefeso, Gabriela Goldberg, Nana Yaa P. S. Opoku, Marcelo Vazquez, Antonella Bertucci, Zhong Chen, Charles Wang, Alysson R. Muotri, Michael J. Pecaut
Publikováno v:
PloS one, vol 18, iss 5
Human exposure to low-to-moderate dose ionizing radiation (LMD-IR) is increasing via environmental, medical, occupational sources. Acute exposure to LMD-IR can cause subclinical damage to cells, resulting in altered gene expression and cellular funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e618b37341f7c0ca323de1d8fef7fa20
https://escholarship.org/uc/item/4fs6p6hb
https://escholarship.org/uc/item/4fs6p6hb
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190982 (2018)
Antibody specificity and diversity are generated through the enzymatic splicing of genomic gene segments within each B cell. Antibodies are heterodimers of heavy- and light-chains encoded on separate loci. We studied the antibody repertoire from pool
Externí odkaz:
https://doaj.org/article/b916f12c94c848c79999cecc802933c0
Publikováno v:
ImmunoHorizons. 5:675-686
Ab repertoire diversity plays a critical role in the host’s ability to fight pathogens. CDR3 is partially responsible for Ab–Ag binding and is a significant source of diversity in the repertoire. CDR3 diversity is generated during VDJ rearrangeme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e240c0d6c126c5a42867356006abc055
https://doi.org/10.4049/immunohorizons.2100056
https://doi.org/10.4049/immunohorizons.2100056
Autor:
Michael J Pecaut, Xiao Wen Mao, Denise L Bellinger, Karen R Jonscher, Louis S Stodieck, Virginia L Ferguson, Ted A Bateman, Robert P Mohney, Daila S Gridley
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0174174 (2017)
The Space Shuttle Atlantis launched on its final mission (STS-135) on July 8, 2011. After just under 13 days, the shuttle landed safely at Kennedy Space Center (KSC) for the last time. Female C57BL/6J mice flew as part of the Commercial Biomedical Te
Externí odkaz:
https://doaj.org/article/4dd5a5e13d5e47a280907faaca132817