Zobrazeno 1 - 10
of 170
pro vyhledávání: '"J. Pattinson"'
Autor:
Barnabas G. Williams, Lloyd D. W. King, David Pulido, Doris Quinkert, Amelia M. Lias, Sarah E. Silk, Robert J. Ragotte, Hannah Davies, Jordan R. Barrett, Kirsty McHugh, Cassandra A. Rigby, Daniel G. W. Alanine, Lea Barfod, Michael W. Shea, Li An Cowley, Rebecca A. Dabbs, David J. Pattinson, Alexander D. Douglas, Oliver R. Lyth, Joseph J. Illingworth, Jing Jin, Cecilia Carnrot, Vinayaka Kotraiah, Jayne M. Christen, Amy R. Noe, Randall S. MacGill, C. Richter King, Ashley J. Birkett, Lorraine A. Soisson, Katherine Skinner, Kazutoyo Miura, Carole A. Long, Matthew K. Higgins, Simon J. Draper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Reticulocyte-binding protein homologue 5 (RH5), a leading blood-stage Plasmodium falciparum malaria vaccine target, interacts with cysteine-rich protective antigen (CyRPA) and RH5-interacting protein (RIPR) to form an essential heterotrimeri
Externí odkaz:
https://doaj.org/article/c0357f954cd04ff984155d03439a386e
Autor:
Daniel J. Browne, Ashton M. Kelly, Jamie Brady, Carla Proietti, Yomani D. Sarathkumara, David J. Pattinson, Denise L. Doolan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The efficacy of pre-erythrocytic stage malaria antigens or vaccine platforms is routinely assessed in murine models challenged with Plasmodium sporozoites. Relative liver-stage parasite burden is quantified using reverse transcription quanti
Externí odkaz:
https://doaj.org/article/33385b24b435431abfbe173b985c6da5
Autor:
Louise Bjerkan, Ganesh Ram R. Visweswaran, Arnar Gudjonsson, Geneviève M. Labbé, Doris Quinkert, David J. Pattinson, Heidi C. L. Spång, Simon J. Draper, Bjarne Bogen, Ranveig Braathen
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Targeted delivery of antigen to antigen presenting cells (APCs) is an efficient way to induce robust antigen-specific immune responses. Here, we present a novel DNA vaccine that targets the Plasmodium falciparum reticulocyte-binding protein homolog 5
Externí odkaz:
https://doaj.org/article/aa3e7e36c41d42eba77b84480a104e26
Autor:
David J. Pattinson, Simon H. Apte, Nani Wibowo, Tania Rivera-Hernandez, Penny L. Groves, Anton P. J. Middelberg, Denise L. Doolan
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Despite extensive research, the development of an effective malaria vaccine remains elusive. The induction of robust and sustained T cell and antibody response by vaccination is an urgent unmet need. Chimeric virus-like particles (VLPs) are a promisi
Externí odkaz:
https://doaj.org/article/0d170ccf359b4ae9a6c7c4cb5d45785b
Autor:
J Pattinson, V Kong, J Bruce, G Oosthuizen, W Bekker, G Laing, D Wood, P Brysiewicz, D Clarke
Publikováno v:
South African Medical Journal, Vol 107, Iss 12, Pp 1082-1085 (2017)
Background. This audit of snakebites was undertaken to document our experience with snakebite in the western part of KwaZulu-Natal (KZN) Province, South Africa (SA).Objective. To document our experience with snakebite in the western part of KZN, and
Externí odkaz:
https://doaj.org/article/f603ca20afd549308f44fd315f6a4110
Autor:
Joseph J. Illingworth, Daniel G. Alanine, Rebecca Brown, Jennifer M. Marshall, Helen E. Bartlett, Sarah E. Silk, Geneviève M. Labbé, Doris Quinkert, Jee Sun Cho, Jason P. Wendler, David J. Pattinson, Lea Barfod, Alexander D. Douglas, Michael W. Shea, Katherine E. Wright, Simone C. de Cassan, Matthew K. Higgins, Simon J. Draper
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The malaria genome encodes over 5,000 proteins and many of these have also been proposed to be potential vaccine candidates, although few of these have been tested clinically. RH5 is one of the leading blood-stage Plasmodium falciparum malaria vaccin
Externí odkaz:
https://doaj.org/article/8f0bf423994b483e9013cc4f10cd07fc
Autor:
David J. Pattinson, Simon H. Apte, Nani Wibowo, Yap P. Chuan, Tania Rivera-Hernandez, Penny L. Groves, Linda H. Lua, Anton P. J. Middelberg, Denise L. Doolan
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
An effective vaccine against the Plasmodium parasite is likely to require the induction of robust antibody and T cell responses. Chimeric virus-like particles are an effective vaccine platform for induction of antibody responses, but their capacity t
Externí odkaz:
https://doaj.org/article/2ab14d53e54c407b842d77fdd23cdede
Autor:
Tovah N. Shaw, Colette A. Inkson, Ana Villegas-Mendez, David J. Pattinson, Patrick Strangward, Kathryn J. Else, Simon J. Draper, Leo A. H. Zeef, Kevin N. Couper
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Cerebral malaria (CM) is one of the most severe complications of Plasmodium falciparum infection. There is evidence that repeated parasite exposure promotes resistance against CM. However, the immunological basis of this infection-induced resistance
Externí odkaz:
https://doaj.org/article/f76009ce46674799ad006d8f4dabb917
Autor:
Yomani D. Sarathkumara, Daniel J. Browne, Ashton M. Kelly, David J. Pattinson, Catherine M. Rush, Jeffrey Warner, Carla Proietti, Denise L. Doolan
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10609
Whole-blood-derived transcriptional profiling is widely used in biomarker discovery, immunological research, and therapeutic development. Traditional molecular and high-throughput transcriptomic platforms, including molecular assays with quantitative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bbb95c5ec0e20379d14124b301c4dc4
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