Zobrazeno 1 - 10
of 14
pro vyhledávání: '"J. Patrick Connick"'
Publikováno v:
Biochem J
Previous studies showed that cytochrome P450 1A2 (CYP1A2) forms a homomeric complex that influences its metabolic characteristics. Specifically, CYP1A2 activity exhibits a sigmoidal response as a function of NADPH-cytochrome P450 reductase (POR) conc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16db68aca41200be3c5994a0e3a187e1
https://doi.org/10.1042/bcj20210269
https://doi.org/10.1042/bcj20210269
Publikováno v:
Biochem J
P450 and heme oxygenase-1 (HO-1) receive their necessary electrons by interaction with the NADPH-cytochrome P450 reductase (POR). As the POR concentration is limiting when compared with P450 and HO-1, they must effectively compete for POR to function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c68e45142220ef43157232aa6dc459
https://pubmed.ncbi.nlm.nih.gov/33394027
https://pubmed.ncbi.nlm.nih.gov/33394027
Publikováno v:
Drug Metabolism and Disposition. 46:197-203
Cytochromes P450s (P450s) catalyze oxygenation reactions via interactions with their redox partners. However, other proteins, particularly other P450s, also have been shown to form complexes that modulate P450 function. Previous studies showed that C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efd2b4bfc1ea8dd8273998edd5bd4bf
https://doi.org/10.1124/dmd.117.078642
https://doi.org/10.1124/dmd.117.078642
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::890cbc045e5a8e621d84cca888979e6d
https://doi.org/10.1096/fasebj.2019.33.1_supplement.673.6
https://doi.org/10.1096/fasebj.2019.33.1_supplement.673.6
Publikováno v:
The Journal of Biological Chemistry
Heme oxygenase 1 (HO-1) and the cytochromes P450 (P450s) are endoplasmic reticulum-bound enzymes that rely on the same protein, NADPH-cytochrome P450 reductase (POR), to provide the electrons necessary for substrate metabolism. Although the HO-1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38845c4bba48dfd6a1cc255c03a5261
https://doi.org/10.1074/jbc.ra120.015911
https://doi.org/10.1074/jbc.ra120.015911
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5a19626718b5064e0ee876b787d06c5
https://doi.org/10.1096/fasebj.2020.34.s1.03641
https://doi.org/10.1096/fasebj.2020.34.s1.03641
Publikováno v:
Biochemical Journal. 446:489-497
Previous studies have shown that the presence of one P450 enzyme can affect the function of another. The goal of the present study was to determine if P450 enzymes are capable of forming homomeric complexes that affect P450 function. To address this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6239d74bfe33903e5c85199bd5079f
https://doi.org/10.1042/bj20120636
https://doi.org/10.1042/bj20120636
Autor:
Satya Prakash Panda, Wayne L. Backes, Karen McCammon, Warren J. Huber, Pavel Martásek, Bettie Sue Siler Masters, J. Patrick Connick, Christopher C. Marohnic, James R. Reed
Publikováno v:
Archives of Biochemistry and Biophysics. 513:42-50
Genetic variations in POR, encoding NADPH-cytochrome P450 oxidoreductase (CYPOR), can diminish the function of numerous cytochromes P450, and also have the potential to block degradation of heme by heme oxygenase-I (HO-1). Purified full-length human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5dee43d6a392cbe7c675c810b83f9b
https://doi.org/10.1016/j.abb.2011.06.008
https://doi.org/10.1016/j.abb.2011.06.008
Autor:
Lianhong Xu, Eric F. Johnson, Manoj C. Desai, D. Fernando Estrada, Emily E. Scott, James R. Reed, Jennifer S. Laurence, J. Patrick Connick, Wayne L. Backes
This report summarizes a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics at Experimental Biology held April 20-24 in Boston, MA. Presentations discussed the status of cytochrome P450 (P450) knowledge, emphas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843806905fb198afa51ccd7ce9ad9b59
https://europepmc.org/articles/PMC3876788/
https://europepmc.org/articles/PMC3876788/
Ligation of polyubiquitin chains to proteins is a fundamental post-translational modification, often resulting in targeted degradation of conjugated proteins. Attachment of polyubiquitin chains requires the activities of an E1 activating enzyme, an E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89dcff0f3b29fa2b2be42c79e9f613d2
https://europepmc.org/articles/PMC3605639/
https://europepmc.org/articles/PMC3605639/