Zobrazeno 1 - 10
of 109
pro vyhledávání: '"J. Palop"'
Autor:
Stephanie R. Miller, Kevin Luxem, Kelli Lauderdale, Pranav Nambiar, Patrick S. Honma, Katie K. Ly, Shreya Bangera, Mary Bullock, Jia Shin, Nick Kaliss, Yuechen Qiu, Catherine Cai, Kevin Shen, K. Dakota Mallen, Zhaoqi Yan, Andrew S. Mendiola, Takashi Saito, Takaomi C. Saido, Alexander R. Pico, Reuben Thomas, Erik D. Roberson, Katerina Akassoglou, Pavol Bauer, Stefan Remy, Jorge J. Palop
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114870- (2024)
Summary: Computer-vision and machine-learning (ML) approaches are being developed to provide scalable, unbiased, and sensitive methods to assess mouse behavior. Here, we used the ML-based variational animal motion embedding (VAME) segmentation platfo
Externí odkaz:
https://doaj.org/article/624d2d95b9884a1bbb7878c8a321d192
Autor:
Kevin Luxem, Petra Mocellin, Falko Fuhrmann, Johannes Kürsch, Stephanie R. Miller, Jorge J. Palop, Stefan Remy, Pavol Bauer
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Variational embeddings of animal motion enable automated discovery of discrete behavioural motifs as well as their latent dynamics.
Externí odkaz:
https://doaj.org/article/c4892a9a2ca94f1b999f09244ffe23aa
Autor:
Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H. Suh, Elliot Thomsen, Jason Dugas, Michelle E. Pizzo, Sarah L. DeVos, Timothy K. Earr, Chia-Ching Lin, Sonnet Davis, Connie Ha, Amy Wing-Sze Leung, Hoang Nguyen, Roni Chau, Ernie Yulyaningsih, Isabel Lopez, Hilda Solanoy, Shababa T. Masoud, Chun-chi Liang, Karin Lin, Giuseppe Astarita, Nathalie Khoury, Joy Yu Zuchero, Robert G. Thorne, Kevin Shen, Stephanie Miller, Jorge J. Palop, Dylan Garceau, Michael Sasner, Jennifer D. Whitesell, Julie A. Harris, Selina Hummel, Johannes Gnörich, Karin Wind, Lea Kunze, Artem Zatcepin, Matthias Brendel, Michael Willem, Christian Haass, Daniel Barnett, Till S. Zimmer, Anna G. Orr, Kimberly Scearce-Levie, Joseph W. Lewcock, Gilbert Di Paolo, Pascal E. Sanchez
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-29 (2022)
Abstract Background Genetic mutations underlying familial Alzheimer’s disease (AD) were identified decades ago, but the field is still in search of transformative therapies for patients. While mouse models based on overexpression of mutated transge
Externí odkaz:
https://doaj.org/article/9eb417ef38964cb082e476c72c827f5f
Autor:
Erik C. B. Johnson, Kaitlyn Ho, Gui-Qiu Yu, Melanie Das, Pascal E. Sanchez, Biljana Djukic, Isabel Lopez, Xinxing Yu, Michael Gill, Weiping Zhang, Jeanne T. Paz, Jorge J. Palop, Lennart Mucke
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-26 (2020)
Abstract Background Alzheimer’s disease (AD) is the most frequent and costly neurodegenerative disorder. Although diverse lines of evidence suggest that the amyloid precursor protein (APP) is involved in its causation, the precise mechanisms remain
Externí odkaz:
https://doaj.org/article/241e604b9e154d01b93f232dcc4d0aa4
Autor:
Jesse E. Hanson, Keran Ma, Justin Elstrott, Martin Weber, Sandrine Saillet, Abdullah S. Khan, Jeffrey Simms, Benjamin Liu, Thomas A. Kim, Gui-Qiu Yu, Yelin Chen, Tzu-Ming Wang, Zhiyu Jiang, Bianca M. Liederer, Gauri Deshmukh, Hilda Solanoy, Connie Chan, Benjamin D. Sellers, Matthew Volgraf, Jacob B. Schwarz, David H. Hackos, Robby M. Weimer, Morgan Sheng, T. Michael Gill, Kimberly Scearce-Levie, Jorge J. Palop
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 381-396.e4 (2020)
Summary: NMDA receptors (NMDARs) play subunit-specific roles in synaptic function and are implicated in neuropsychiatric and neurodegenerative disorders. However, the in vivo consequences and therapeutic potential of pharmacologically enhancing NMDAR
Externí odkaz:
https://doaj.org/article/086ee7e911424901b05bcdfb74e615c9
Autor:
Inma Cobos, Jorge J. Palop
Publikováno v:
Nature. 612:218-220
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60cffa18cecd8bded319f72786c4a69a
https://doi.org/10.1038/d41586-022-03800-7
https://doi.org/10.1038/d41586-022-03800-7
Small-molecule ketone esters treat brain network abnormalities in an Alzheimer’s disease mouse model
Autor:
John C. Newman, Keran Ma, François Kroll, Erin Higgins, Scott Ulrich, Jorge J. Palop, Eric Verdin
SummaryAltered brain network activity and the resulting hypersynchrony are important for the pathogenesis of cognitive decline in Alzheimer’s disease (AD) mouse models. Treatments that reduce epileptiform discharges (EDs) or network hyperactivity i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef8d64bc1020e6fff6d0ef9f89273d1e
https://doi.org/10.1101/2022.09.24.509337
https://doi.org/10.1101/2022.09.24.509337
Autor:
Reuben Thomas, Terry Dean, Mark A. Petersen, Matthias G. Haberl, Jae K. Ryu, Victoria A. Rafalski, Andrew S. Mendiola, Eric A. Bushong, Keunyoung Kim, Daniel Naranjo Sampson, Elif G. Sozmen, Reshmi Tognatta, Rosa Meza Acevedo, Zhaoqi Yan, Shaun R. Coughlin, Mark H. Ellisman, Pamela E. Rios Coronado, Belinda S. Cabriga, Jorge J. Palop, Sophia Bardehle, Mario Merlini, Katerina Akassoglou, Matthew Madany, Keran Ma
Publikováno v:
Nature Neuroscience. 24:19-23
Microglial surveillance is a key feature of brain physiology and disease. Here, we found that Gi-dependent microglial dynamics prevent neuronal network hyperexcitability. By generating MgPTX mice to genetically inhibit Gi in microglia, we show that s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d558dcdacc49cb06330157f8ecf84e06
https://doi.org/10.1038/s41593-020-00756-7
https://doi.org/10.1038/s41593-020-00756-7
Autor:
Hilda Solanoy, Morgan Sheng, Gui-Qiu Yu, Jesse E. Hanson, Gauri Deshmukh, Benjamin D. Sellers, Tzu-Ming Wang, Yelin Chen, Justin Elstrott, Connie Chan, Zhiyu Jiang, Thomas A. Kim, David H. Hackos, Jacob Schwarz, Jorge J. Palop, T. Michael Gill, Matthew Volgraf, Keran Ma, Jeffrey Simms, Kimberly Scearce-Levie, Martin Weber, Bianca M. Liederer, Sandrine Saillet, Abdullah S. Khan, Robby M. Weimer, Benjamin Liu
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 381-396.e4 (2020)
Elsevier
Cell reports, vol 30, iss 2
Cell reports
Elsevier
Cell reports, vol 30, iss 2
Cell reports
SUMMARY NMDA receptors (NMDARs) play subunit-specific roles in synaptic function and are implicated in neuropsychiatric and neurodegenerative disorders. However, the in vivo consequences and therapeutic potential of pharmacologically enhancing NMDAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b0ddfb3fdc3d2e4aa7d6b4342a59d2
http://www.sciencedirect.com/science/article/pii/S2211124719316808
http://www.sciencedirect.com/science/article/pii/S2211124719316808
Autor:
Jorge J. Palop
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::280fe4442d6057b21a1475f645e16d13
https://doi.org/10.1002/alz.040396
https://doi.org/10.1002/alz.040396