Zobrazeno 1 - 10
of 142
pro vyhledávání: '"J. Pablo Huidobro‐Toro"'
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
The vesicular nucleotide transporter (VNUT) is critical for sympathetic co-transmission and purinergic transmission maintenance. To examine this proposal, we assessed whether the bisphosphonate clodronate, claimed as a potent in vitro VNUT blocker, m
Externí odkaz:
https://doaj.org/article/6c1ca1f1c1a749b6b7276874584f5242
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 16 (2021)
Background The vascular pharmacodynamics of anthocyanins is only partially understood. To examine whether the anthocyanin‐induced vasorelaxation is related to membrane estrogen receptor activity, the role of ERα or GPER antagonism was ascertained
Externí odkaz:
https://doaj.org/article/88a98d808e3b4905a7e7db3f8ee8c89c
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7288 (2021)
To ascertain the role of Zn(II) as an allosteric modulator on P2X4R, QM/MM molecular dynamic simulations were performed on the WT and two P2X4R mutants suggested by previous electrophysiological data to affect Zn(II) binding. The Gibbs free energy fo
Externí odkaz:
https://doaj.org/article/0c33163311424627844b36350afd0ff1
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6940 (2020)
P2 × 4R is allosterically modulated by Zn(II), and despite the efforts to understand the mechanism, there is not a consensus proposal; C132 is a critical amino acid for the Zn(II) modulation, and this residue is located in the receptor head domain,
Externí odkaz:
https://doaj.org/article/730fa0913aef4fcea37fa6aac1633054
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Since the mechanism of human diabetic peripheral neuropathy and vascular disease in type 1 diabetes mellitus remains unknown, we assessed whether sympathetic transmitter overflow is altered by this disease and associated to vascular dysfunction. Diab
Externí odkaz:
https://doaj.org/article/b413bdba1c414ea4989d312f8290c746
Autor:
Elias Leiva-Salcedo, Claudio Coddou, Felipe E. Rodríguez, Antonello Penna, Ximena Lopez, Tanya Neira, Ricardo Fernández, Mónica Imarai, Miguel Rios, Jorge Escobar, Margarita Montoya, J. Pablo Huidobro-Toro, Alejandro Escobar, Claudio Acuña-Castillo
Publikováno v:
Mediators of Inflammation, Vol 2011 (2011)
The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) is one of the strongest stimu
Externí odkaz:
https://doaj.org/article/70ed529568aa4b4d9626a6b70ddc95c5
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2011 (2011)
Although the physiological function of the cellular prion protein (PrPC) remains unknown, several evidences support the notion of its role in copper homeostasis. PrPC binds Cu2+ through a domain composed by four to five repeats of eight amino acids.
Externí odkaz:
https://doaj.org/article/08da6f19c4a64af28ba67d4f70b3755e
Publikováno v:
Comptes Rendus. Chimie. 23:3-16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc9e73a86a0949cdce98f7317f563204
https://doi.org/10.5802/crchim.2
https://doi.org/10.5802/crchim.2
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The vascular pharmacodynamics of anthocyanins is only partially understood. To examine whether the anthocyanin‐induced vasorelaxation is related to membrane estrogen receptor activity, the role of ERα or GPER antagonism was ascertained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f13b57ddd175a745c715796c0be5a3
https://pubmed.ncbi.nlm.nih.gov/34350775
https://pubmed.ncbi.nlm.nih.gov/34350775
Autor:
J. Pablo Huidobro-Toro, Felipe Hernández, M. Verónica Donoso, Claudio Acuña-Castillo, Tania Villalón
Publikováno v:
Purinergic Signalling. 14:121-139
Endothelial cells participate in extracellular ATP release elicited by mechanosensors. To characterize the dynamic interactions between mechanical and chemical factors that modulate ATP secretion by the endothelium, we assessed and compared the mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639d4431f929332ba971d38f50b7f73b
https://doi.org/10.1007/s11302-017-9599-7
https://doi.org/10.1007/s11302-017-9599-7