Zobrazeno 1 - 10
of 179
pro vyhledávání: '"J. Pablo Huidobro‐Toro"'
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
The vesicular nucleotide transporter (VNUT) is critical for sympathetic co-transmission and purinergic transmission maintenance. To examine this proposal, we assessed whether the bisphosphonate clodronate, claimed as a potent in vitro VNUT blocker, m
Externí odkaz:
https://doaj.org/article/6c1ca1f1c1a749b6b7276874584f5242
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 16 (2021)
Background The vascular pharmacodynamics of anthocyanins is only partially understood. To examine whether the anthocyanin‐induced vasorelaxation is related to membrane estrogen receptor activity, the role of ERα or GPER antagonism was ascertained
Externí odkaz:
https://doaj.org/article/88a98d808e3b4905a7e7db3f8ee8c89c
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7288 (2021)
To ascertain the role of Zn(II) as an allosteric modulator on P2X4R, QM/MM molecular dynamic simulations were performed on the WT and two P2X4R mutants suggested by previous electrophysiological data to affect Zn(II) binding. The Gibbs free energy fo
Externí odkaz:
https://doaj.org/article/0c33163311424627844b36350afd0ff1
Autor:
J. Pablo Huidobro - Toro
Publikováno v:
ARS Medica, Vol 12, Iss 2, Pp 39-47 (2017)
Sin resumen
Externí odkaz:
https://doaj.org/article/8cfbe4f7025840e0835ea66af199b567
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6940 (2020)
P2 × 4R is allosterically modulated by Zn(II), and despite the efforts to understand the mechanism, there is not a consensus proposal; C132 is a critical amino acid for the Zn(II) modulation, and this residue is located in the receptor head domain,
Externí odkaz:
https://doaj.org/article/730fa0913aef4fcea37fa6aac1633054
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Since the mechanism of human diabetic peripheral neuropathy and vascular disease in type 1 diabetes mellitus remains unknown, we assessed whether sympathetic transmitter overflow is altered by this disease and associated to vascular dysfunction. Diab
Externí odkaz:
https://doaj.org/article/b413bdba1c414ea4989d312f8290c746
Publikováno v:
Comptes Rendus. Chimie. 23:3-16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc9e73a86a0949cdce98f7317f563204
https://doi.org/10.5802/crchim.2
https://doi.org/10.5802/crchim.2
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The vascular pharmacodynamics of anthocyanins is only partially understood. To examine whether the anthocyanin‐induced vasorelaxation is related to membrane estrogen receptor activity, the role of ERα or GPER antagonism was ascertained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f13b57ddd175a745c715796c0be5a3
https://pubmed.ncbi.nlm.nih.gov/34350775
https://pubmed.ncbi.nlm.nih.gov/34350775
Autor:
Fernando Valiente-Echeverría, Maricarmen Vallejos, Anne Monette, Karla Pino, Alejandro Letelier, J Pablo Huidobro-Toro, Andrew J Mouland, Marcelo López-Lastra
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56962 (2013)
Translation initiation from the human immunodeficiency virus type-1 (HIV-1) mRNA can occur through a cap or an IRES dependent mechanism. Cap-dependent translation initiation of the HIV-1 mRNA can be inhibited by the instability element (INS)-1, a cis
Externí odkaz:
https://doaj.org/article/554fc09d028f4c5a91f6531c82a0caac
Autor:
J. Pablo Huidobro-Toro, Felipe Hernández, M. Verónica Donoso, Claudio Acuña-Castillo, Tania Villalón
Publikováno v:
Purinergic Signalling. 14:121-139
Endothelial cells participate in extracellular ATP release elicited by mechanosensors. To characterize the dynamic interactions between mechanical and chemical factors that modulate ATP secretion by the endothelium, we assessed and compared the mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639d4431f929332ba971d38f50b7f73b
https://doi.org/10.1007/s11302-017-9599-7
https://doi.org/10.1007/s11302-017-9599-7