Zobrazeno 1 - 10
of 401
pro vyhledávání: '"J. PRUD'HOMME"'
Autor:
Gérald J. Prud’homme, Qinghua Wang
Publikováno v:
Cells, Vol 13, Iss 17, p 1413 (2024)
The α-Klotho protein (hereafter Klotho) is an obligate coreceptor for fibroblast growth factor 23 (FGF23). It is produced in the kidneys, brain and other sites. Klotho insufficiency causes hyperphosphatemia and other anomalies. Importantly, it is as
Externí odkaz:
https://doaj.org/article/b48c650ae9f8405b8d6c8ca83d47e006
Causal effects of non-alcoholic fatty liver disease on osteoporosis: a Mendelian randomization study
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundOsteoporosis (OP) is a systemic skeletal disease characterized by compromised bone strength leading to an increased risk of fracture. There is an ongoing debate on whether non-alcoholic fatty liver disease (NAFLD) is an active contributor o
Externí odkaz:
https://doaj.org/article/c4127a0cedb34e8c8e8c3abbbcd4f84a
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened lifespan, stunted growth, renal disease, hyperphosphatemia, hypercalce
Externí odkaz:
https://doaj.org/article/3a779411c58e4f9fbc77cf2071ef7021
Autor:
Gerald J Prud'homme
Publikováno v:
McGill Journal of Medicine, Vol 1, Iss 1 (2020)
Hypersensitivity is synonymous with immune-mediated tissue injury. Hypersensitivity reactions occur in several forms and give rise to numerous conditions including allergies, autoimmune disease, allograft rejection, granulomatous inflammation, and a
Externí odkaz:
https://doaj.org/article/234ecc81b17649a8b0e33b5a9fd3289c
Autor:
Liwei Ren, Qiaoli Cui, Wenjuan Liu, Liqian Wang, Yijing Liao, Ying Feng, Wanwan Sun, Yehong Yang, Zhaoyun Zhang, Tianru Jin, Gerald J. Prud’homme, Lina Zhang, Yiming Li, Ying Leng, Qinghua Wang
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Glucagon-like peptide-1 (GLP-1), an incretin hormone plays an important role in regulating glucose homeostasis. The therapeutic use of native GLP-1 is inadequate due to its short in vivo half-life. We recently developed a novel GLP-1 mimetics supaglu
Externí odkaz:
https://doaj.org/article/a461304ed6434fb983d3e776bc6ce002
Autor:
Wenjuan Liu, Dong Ok Son, Harry K. Lau, Yinghui Zhou, Gerald J. Prud’homme, Tianru Jin, Qinghua Wang
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
γ-aminobutyric acid (GABA) or glucagon-like peptide-1 based drugs, such as sitagliptin (a dipeptidyl peptidase-4 inhibitor), were shown to induce beta cell regenerative effects in various diabetic mouse models. We propose that their combined adminis
Externí odkaz:
https://doaj.org/article/eeeafde34b9441d7ab7b97177cdc9824
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Zhaoyun Zhang, Yehong Yang, Qinghua Wang, Tianru Jin, Wenjuan Liu, Dong Ok Son, Harry Kevin Lau, Gerald J. Prud'homme, Yiming Li
Publikováno v:
Journal of Endocrinology. 248:133-143
γ-Aminobutyric acid (GABA) and glucagon-like peptide-1 receptor agonist (GLP-1RA) improve rodent β-cell survival and function. In human β-cells, GABA exerts stimulatory effects on proliferation and anti-apoptotic effects, whereas GLP-1RA drugs hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf44f8094817bfa934f40a69731763d8
https://doi.org/10.1530/joe-20-0315
https://doi.org/10.1530/joe-20-0315
Autor:
ZHIHONG WANG, LINLING FAN, YUNZHI NI, ANRAN MA, DI WU, QIAOLI CUI, YUE ZHOU, YAN-RU LOU, GERALD J. PRUD'HOMME, QINGHUA WANG
Publikováno v:
Diabetes. 71
Excessive loss of islet beta cells is a major cause for the development of type 2 diabetes (T2D) , and seeking an effective method to enhance beta cell proliferation is a promising therapeutic strategy for T2D. In this study, we examined whether comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::542f7e476315e6e83ff85b0a93651800
https://doi.org/10.2337/db22-256-lb
https://doi.org/10.2337/db22-256-lb