Výsledky vyhledávání - "J. P. Tizzano"

Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors

Autor: D R, Helton, J P, Tizzano, J A, Monn, D D, Schoepp, M J, Kallman

Publikováno v: The Journal of pharmacology and experimental therapeutics. 284(2)

LY354740 is a conformationally constrained analog of glutamate which is a potent agonist for group II cAMP coupled metabotropic glutamate receptors (mGluRs). The discovery of this novel pharmacological agent has allowed the exploration of the functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::45a25f9b622d548ccb9c488b80c36ee8
https://pubmed.ncbi.nlm.nih.gov/9454811

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Developmental toxicity of gemcitabine, an antimetabolite oncolytic, administered during gestation to CD-1 mice

Autor: J. P. Tizzano, J. A. Eudaly, G. C. Todd, G. L. Higdon

Publikováno v: Teratology. 48(4)

Gemcitabine was given intravenously to female mice on gestation days (GD) 6-15 at doses of 0, 0.05, 0.25, or 1.5 mg/kg/day (0, 0.15, 0.75, or 4.5 mg/m2/day, respectively). Animals assigned to the teratology segment (25/group) were killed on GD 18 for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c669d3e8c4c74058c52e98eda5a7d94
https://pubmed.ncbi.nlm.nih.gov/8278936

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