Zobrazeno 1 - 10
of 18
pro vyhledávání: '"J. P. Seibyl"'
Publikováno v:
IEEE Transactions on Nuclear Science. 51:2649-2653
Use of an artificial neural network (ANN) has been previously shown to be an effective tool in compensating scatter and crosstalk from the primary photons in simultaneous dual radionuclide imaging. Generally, a large number of input energy windows ar
Publikováno v:
The international tinnitus journal. 6(2)
As regards the symptom of a predominantly central tinnitus of the severe, disabling type, it has been hypothesized that a deficiency in the benzodiazepine receptor exists in the medial temporal lobe system of brain and is directly related to affect i
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 41(9)
Nicotinic acetylcholine receptors (nAChRs) play an important role in tobacco dependence and a potential therapeutic role in neuropsychiatric disorders such as Alzheimer's disease. [123I]5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine (5-I-A-85380) is a n
Autor:
A, Varrone, M, Fujita, N P, Verhoeff, S S, Zoghbi, R M, Baldwin, N, Rajeevan, D S, Charney, J P, Seibyl, R B, Innis
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 41(8)
This study evaluated the test-retest reproducibility of D2 receptor quantification in the thalamus and temporal cortex using [123I]epidepride SPECT.Ten healthy volunteers (4 men, 6 women; age range, 19-46 y) underwent 2 SPECT studies (interval, 2-26
Autor:
M, Ichise, M, Fujita, J P, Seibyl, N P, Verhoeff, R M, Baldwin, S S, Zoghbi, N, Rajeevan, D S, Charney, R B, Innis
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 40(11)
The purpose of this study was to extend the graphical analysis of reversible tracer binding to account for labeled lipophilic metabolites (metabolites) in quantifying [123I]epidepride binding to striatal and extrastriatal D2 receptors and, additional
Autor:
M, Fujita, J P, Seibyl, N P, Verhoeff, M, Ichise, R M, Baldwin, S S, Zoghbi, C, Burger, J K, Staley, N, Rajeevan, D S, Charney, R B, Innis
Publikováno v:
Synapse (New York, N.Y.). 34(4)
Quantitative SPECT measures of dopamine D(2) like receptors with [(123)I]epidepride is complicated by its high affinity and lipophilic metabolites. The purpose of this study was to use both parent (P) and lipophilic metabolites (M) as input functions
Publikováno v:
Movement disorders : official journal of the Movement Disorder Society. 14(3)
The effect of subchronic treatment with L-dopa/carbidopa or L-selegiline on striatal dopamine transporters (DAT) was examined in patients with idiopathic Parkinson's disease with SPECT (single photon emission computed tomography) using [123I]beta-CIT
Autor:
J P, Seibyl, K, Marek, K, Sheff, S, Zoghbi, R M, Baldwin, D S, Charney, C H, van Dyck, R B, Innis
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 39(9)
Iodine-123-beta-carbomethoxy-3 beta-(4-iodophenyltropane) (CIT) has been used as a probe of dopamine transporters in Parkinson's disease patients using SPECT. This tracer has a protracted period of striatal uptake enabling imaging 14-24 hr postinject
Autor:
A, Abi-Dargham, R, Gil, J, Krystal, R M, Baldwin, J P, Seibyl, M, Bowers, C H, van Dyck, D S, Charney, R B, Innis, M, Laruelle
Publikováno v:
The American journal of psychiatry. 155(6)
The authors previously observed an increase in striatal dopamine transmission following amphetamine challenge in 15 untreated patients with schizophrenia compared to 15 matched healthy subjects. The purpose of this study was to replicate this finding
Autor:
R T, Malison, S E, Best, C H, van Dyck, E F, McCance, E A, Wallace, M, Laruelle, R M, Baldwin, J P, Seibyl, L H, Price, T R, Kosten, R B, Innis
Publikováno v:
The American journal of psychiatry. 155(6)
The authors examined whether striatal dopamine transporters were altered in acutely (96 hours or less) abstinent cocaine-abusing subjects, as suggested by postmortem studies.[123I] beta-CIT and single photon emission computed tomography were used to