Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability

Autor: Anette Müllertz, Patrick Augustijns, David Dahlgren, Hans Lennernäs, C. Skjöld, Per M. Hellström, J.-P. Ridoux, René Holm, M. Venczel

Publikováno v: Dahlgren, D, Venczel, M, Ridoux, J P, Skjöld, C, Müllertz, A, Holm, R, Augustijns, P, Hellström, P M & Lennernäs, H 2021, ' Fasted and fed state human duodenal fluids : Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 163, pp. 240-251 . https://doi.org/10.1016/j.ejpb.2021.04.005

Accurate in vivo predictions of intestinal absorption of low solubility drugs require knowing their solubility in physiologically relevant dissolution media. Aspirated human intestinal fluids (HIF) are the gold standard, followed by simulated intesti

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https://lirias.kuleuven.be/handle/123456789/674254

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Conformational flexibility in the right-handed and in the left-handed double helices of Na+-d(m5C-G-T-A-m5C-G) studied by I R spectroscopy

Autor: Jean Liquier, Eliane Taillandier, S. Adam, J. P. Ridoux

Publikováno v: Nucleic Acids Research. 16:5621-5630

The X ray diffraction study of a d(m5C-G-A-T-m5C-G) crystals has shown the existence of a 2 conformation while the Raman spectroscopy study of the same fragment in solution showed that then the oligonucleotide adopted a B geometry. Infrared spectrosc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98c7de38e903eaf3146547ea0dd22b3
https://doi.org/10.1093/nar/16.12.5621

Z form of poly d(A–C).poly d(G–T) in solution studied by Raman spectroscopy

Autor: Eliane Taillandier, Jean Liquier, J. P. Ridoux

Publikováno v: Nucleic Acids Research. 15:5813-5822

Poly d(A-C).poly d(G-T) structures have been studied in solution by Raman spectroscopy, in presence of Na+, Mn2+ and Ni2+ counterions. Increase of the Na+ concentration or addition of Mn2+ ions up to 1M MnCl2 does not modify the B geometry of the pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d121d48202a283b2bef1c806d81cb8a9
https://doi.org/10.1093/nar/15.14.5813

IR and UV studies on stability and conformations of short DNA duplexes containing a no-base residue: coexistence of B and Z conformations

Autor: Tam Huynh-Dinh, P. Bourtayre, Jean Igolen, J. P. Ridoux, Eliane Taillandier, S. Adam, Sylvie Pochet

Publikováno v: Journal of biomolecular structuredynamics. 6(1)

Tridecamers containing a central no-base residue (X) have been synthesized and hybridized to their complementary strands, so as to constitute duplexes consisting of two hexamers separated by central mismatched X-A or X-T pairs. The effect of the intr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f97b517a8a7d9dc8f2085e5bffa4da
https://pubmed.ncbi.nlm.nih.gov/3271517