Zobrazeno 1 - 10
of 29
pro vyhledávání: '"J. P. McKean"'
Autor:
Jonah J. Scott-McKean, Mieko Matsuyama, Charles W. Guo, Lin Ni, Brandon Sassouni, Shree Kurup, Robert Nickells, Shigemi Matsuyama
Publikováno v:
Cells, Vol 13, Iss 11, p 911 (2024)
BAX plays an essential role in retinal ganglion cell (RGC) death induced by optic nerve injury. Recently, we developed M109S, an orally bioactive and cytoprotective small compound (CPSC) that inhibits BAX-mediated cell death. We examined whether M109
Externí odkaz:
https://doaj.org/article/a788a8902b2149d18f8a5247fbd7bd88
Autor:
Daniella B. Victorino, Daniel J. L. L. Pinheiro, Jonah J. Scott-McKean, Sarah Barker, Melissa R. Stasko, Jean Faber, Carla A. Scorza, Alberto C. S. Costa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Mounting evidence implicates dysfunctional GABAAR-mediated neurotransmission as one of the underlying causes of learning and memory deficits observed in the Ts65Dn mouse model of Down syndrome (DS). The specific origin and nature of such dys
Externí odkaz:
https://doaj.org/article/5901e46d3ede478a8d1e006e2f931c75
Autor:
Jonah J. Scott-McKean, Ryan Jones, Mark W. Johnson, Joyce Mier, Ines A. Basten, Melissa R. Stasko, Alberto C. S. Costa
Publikováno v:
Brain Sciences, Vol 13, Iss 5, p 743 (2023)
Down syndrome (DS), which results from the complete or partial trisomy of chromosome 21 (trisomy-21), is the most common genetically defined cause of intellectual disability. Trisomy-21 also produces, or is associated with, many neurodevelopmental ph
Externí odkaz:
https://doaj.org/article/f644b1927676431189a22d636eb34274
Autor:
Ewa D. Bieber, Gail A. Edelsohn, Maria E. McGee, Julia Shekunov, Magdalena Romanowicz, Jennifer L. Vande Voort, Alastair J. S. McKean
Publikováno v:
Frontiers in Psychiatry, Vol 11 (2020)
Introduction: Parents/legal guardians are medical decision-makers for their minor children. Lack of parental capacity to appreciate the implications of the diagnosis and consequences of refusing recommended treatment may impede pediatric patients fro
Externí odkaz:
https://doaj.org/article/e0d4eed3949c4a248801fa3092184f6c
Autor:
Devon M Powell, Simona Vegetti, J P McKean, Cristiana Spingola, Hannah R Stacey, Christopher D Fassnacht
Publikováno v:
Monthly Notices of the Royal Astronomical Society, 516, 1808-1828. Oxford University Press
We investigate the mass structure of a strong gravitational lens galaxy at $z=0.350$, taking advantage of the milli-arcsecond (mas) angular resolution of very long baseline interferometric (VLBI) observations. In the first analysis of its kind at thi
Autor:
Susan K. Kozawa, Audrey Lord, Jonah J. Scott-McKean, Anne Y. Walker, Alberto C. S. Costa, Gary E. Wnek
Publikováno v:
Gels, Vol 7, Iss 2, p 37 (2021)
Poly(acrylic acid) (PAA) bulk gels and threads, typically derived via free-radical polymerization, are of interest as anionic polyelectrolyte mimics of cellular cytosol and as models for early protocells. The thread dimensions have been limited by th
Externí odkaz:
https://doaj.org/article/ce57647a2ff74eb3921a911cb46770fe
Autor:
Jonah J. Scott-McKean, Krystyna Surewicz, Jin-Kyu Choi, Vernon A. Ruffin, Ahlam I. Salameh, Krzysztof Nieznanski, Alberto C.S. Costa, Witold K. Surewicz
Publikováno v:
Neurobiology of Disease, Vol 91, Iss , Pp 124-131 (2016)
The pathogenic process in Alzheimer's disease (AD) appears to be closely linked to the neurotoxic action of amyloid-β (Aβ) oligomers. Recent studies have shown that these oligomers bind with high affinity to the membrane-anchored cellular prion pro
Externí odkaz:
https://doaj.org/article/af5552d344b44fee9ff49de3a1136663
While the direct detection of the dark-matter particle remains very challenging, the nature of dark matter could be possibly constrained by comparing the observed abundance and properties of small-scale sub-galactic mass structures with predictions f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5086d2770bc9bdea773f1282c509531c
Publikováno v:
Monthly Notices of the Royal Astronomical Society, 510(4), 5891-5907. Oxford University Press
Monthly Notices of the Royal Astronomical Society
Monthly Notices of the Royal Astronomical Society
We present DECORAS, a deep learning based approach to detect both point and extended sources from Very Long Baseline Interferometry (VLBI) observations. Our approach is based on an encoder-decoder neural network architecture that uses a low number of
Publikováno v:
Monthly Notices of the Royal Astronomical Society, 517, 3377-3391. Oxford University Press
Monthly Notices of the Royal Astronomical Society, 517(3), 3377-3391
Monthly Notices of the Royal Astronomical Society, 517(3), 3377-3391
Recent studies have suggested that red quasars are a phase in quasar evolution when feedback from black hole accretion evacuates obscuring gas from the nucleus of the host galaxy. Here, we report a direct link between dust-reddening and molecular out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88b17d5a6d72fbc3071a1c958fe3a73
https://research.rug.nl/en/publications/94ac6d4c-d492-46fe-b8e0-8a9db8f53f07
https://research.rug.nl/en/publications/94ac6d4c-d492-46fe-b8e0-8a9db8f53f07