Zobrazeno 1 - 10
of 27
pro vyhledávání: '"J. P. McGovren"'
Autor:
W C, Zamboni, C F, Stewart, P J, Cheshire, L B, Richmond, S K, Hanna, X, Luo, C, Poquette, J P, McGovren, J A, Houghton, P J, Houghton
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 4(3)
Irinotecan, administered i.v. on days 1-5 and 8-12 [(dx5)2 i.v.] has demonstrated significant activity against advanced human tumor xenografts. To explore the feasibility of prolonged oral administration of irinotecan, we compared the efficacy of ora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::657594edf6931881a461777533167a22
https://pubmed.ncbi.nlm.nih.gov/9533544
https://pubmed.ncbi.nlm.nih.gov/9533544
Autor:
S. J. Mattern, Pitts Tw, Roy A. Johnson, Eldon G. Nidy, Thomas F. DeKoning, Chidester Cg, I. Gebhard, Paul J. Dobrowolski, Samuel J. Qualls, J. P. McGovren, Lopes Nm, Wicnienski Nancy Anne, Kelly Robert C, Weed Sd
Publikováno v:
Journal of medicinal chemistry. 40(18)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778ccca61aa3cde2f9a63b4f9e495732
https://pubmed.ncbi.nlm.nih.gov/9288161
https://pubmed.ncbi.nlm.nih.gov/9288161
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 2(7)
Bizelesin (U-77779, NSC 615291), a synthetic analogue of the cytotoxic antibiotic CC-1065, is a bifunctional alkylating agent that produces DNA interstrand cross-links. Bizelesin was evaluated for antitumor activity against a broad spectrum of syngen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::296f5ad56018dffe2cdcac8aec2d16d1
https://pubmed.ncbi.nlm.nih.gov/9816280
https://pubmed.ncbi.nlm.nih.gov/9816280
Publikováno v:
Cancer research. 52(20)
Adozelesin (U-73975) is an extremely potent cytotoxic agent which causes 90% lethality, after 2 h exposure in vitro, of Chinese hamster ovary and lung (CHO and V79), mouse melanoma (B16), and human ovarian carcinoma (A2780) cells at 0.33, 0.19, 0.2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::524a8896791c2ba2acb38084ca14f8a9
https://pubmed.ncbi.nlm.nih.gov/1394193
https://pubmed.ncbi.nlm.nih.gov/1394193
Autor:
L H, Li, T F, DeKoning, R C, Kelly, W C, Krueger, J P, McGovren, G E, Padbury, G L, Petzold, T L, Wallace, R J, Ouding, M D, Prairie
Publikováno v:
Cancer research. 52(18)
The cyclopropylpyrroloindole analogues are DNA minor-groove binders containing a cyclopropyl group, which mediates N3-adenine covalent adduct formation in a sequence-selective fashion. Carzelesin (U-80244) is a cyclopropylpyrroloindole prodrug contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::106394633bd1cdfcbfc6279a648baf5c
https://pubmed.ncbi.nlm.nih.gov/1516047
https://pubmed.ncbi.nlm.nih.gov/1516047
Publikováno v:
Cancer research. 50(17)
Acivicin is an investigational amino acid antitumor antibiotic currently being evaluated in Phase II clinical trials. In humans acivicin causes reversible, dose-limiting central nervous system (CNS) effects including somnolence, ataxia, personality c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3c14c2637d753dc5dbc8b51b690e931
https://pubmed.ncbi.nlm.nih.gov/2386952
https://pubmed.ncbi.nlm.nih.gov/2386952
Publikováno v:
The Journal of Antibiotics. 31:336-342
It has been shown that the antitumor antibiotics daunomycin (1) and adriamycin (4) are metabolized by microorganisms in a fashion similar to their metabolism by mammalian cells. Both the fungus Mucor spinosus and its cell-free extracts reduce the 13-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2859e60577b970e324b406d5f175676
https://doi.org/10.7164/antibiotics.31.336
https://doi.org/10.7164/antibiotics.31.336
Autor:
J. C. Cook, H. Meng, P. D. Zierath, L. A. Gaudioso, H. E. Renis, R. E. Gutowsky, Kenneth L. Rinehart, G. R. Wilson, P. G. Canonico, L. S. Shield, James B. Gloer, M. L. Moore, Ramesh C. Pandey, L. H. Li, J. P. McGovren
Publikováno v:
Pure and Applied Chemistry. 54:2409-2424
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd23a20dee773bdb0a24397a180f0ace
https://doi.org/10.1351/pac198254122409
https://doi.org/10.1351/pac198254122409
Autor:
William C. Krueger, I. Gebhard, M. D. Prairie, Martha A. Warpehoski, Wicnienski Nancy Anne, Kelly Robert C, J. P. McGovren, Wendell Wierenga, L. H. Li
Publikováno v:
Journal of Medicinal Chemistry. 31:590-603
The synthesis, physicochemical properties, and biological activities of a series of novel spiro cyclopropyl compounds, modeled on the potent antitumor antibiotic CC-1065 (1), are described. Many of these synthetic analogues are significantly more eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d3592c7e9236dd34bf899505c9398b
https://doi.org/10.1021/jm00398a017
https://doi.org/10.1021/jm00398a017
Autor:
H. E. Renis, R. G. Hughes, E. B. Swynenberg, James B. Gloer, S. L. Kuentzel, L. H. Li, J. P. McGovren, Dale A. Stringfellow, Kenneth L. Rinehart
Publikováno v:
Science. 212:933-935
Extracts of samples of a Caribbean tunicate (ascidian, sea squirt) of the family Didemnidae inhibit in vitro at low concentrations the growth of DNA and RNA viruses as well as L1210 leukemic cells. The active compounds isolated from the tunicate, did
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9d24bfbeb059e4f6fb51d5c29fb2e3
https://doi.org/10.1126/science.7233187
https://doi.org/10.1126/science.7233187