Výsledky vyhledávání - "J. P. Kochan"

Functional contributions of the FcepsilonRIalpha and FepsilonRIgamma subunit domains in FcepsilonRI-mediated signaling in mast cells

Autor: B Repetto, G Bandara, H Kado-Fong, J D Larigan, G A Wiggan, D Pocius, M Basu, A M Gilfillan, J P Kochan

Publikováno v: The Journal of Immunology. 156:4876-4883

The functional contributions of the alpha and gamma subunit domains of the high affinity receptor for IgE (Fcepsilon-RI) were determined following chimeric receptor aggregation. Chimeric receptors of the extracellular (EC) and cytoplasmic tail (CT) d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec21c9607193310d1ed09ec911236230
https://doi.org/10.4049/jimmunol.156.12.4876

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Rat class III Fc gamma receptor isoforms differ in IgG subclass-binding specificity and fail to associate productively with rat CD3 zeta

Autor: D L Farber, R Giorda, M Y Nettleton, M Trucco, J P Kochan, D W Sears

Publikováno v: The Journal of Immunology. 150:4364-4375

Several new rat class III Fc gamma R isoforms are described here, extending the genetic complexity of this receptor family and further distinguishing rat CD16 from mouse CD16, represented by only one receptor isoform, and human CD16, represented by o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::580462bd15aba9704d32c3f91d815fb5
https://doi.org/10.4049/jimmunol.150.10.4364

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Conservation of signal transduction mechanisms via the human Fc epsilon RI alpha after transfection into a rat mast cell line, RBL 2H3

Autor: A M Gilfillan, H Kado-Fong, G A Wiggan, J Hakimi, U Kent, J P Kochan

Publikováno v: The Journal of Immunology. 149:2445-2451

The high affinity receptor for IgE (Fc epsilon RI) is present on mast cells and basophils, and the aggregation of IgE-occupied receptors by Ag is responsible for the release of allergic mediators. The Fc epsilon RI is composed of at least three diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c1d0887f43a0d73662d31e04ad8e66e
https://doi.org/10.4049/jimmunol.149.7.2445

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Association of the human Fc epsilon RI gamma subunit with novel cell surface polypeptides

Autor: J T Schöneich, V L Wilkinson, H Kado-Fong, D H Presky, J P Kochan

Publikováno v: The Journal of Immunology. 148:2181-2185

It has recently been demonstrated that the gamma-subunits of the high affinity Fc epsilon RI are required for the cell surface expression of not only the Fc epsilon RI alpha-subunit, but also for the low affinity Fc gamma RIIIA alpha (CD16). In addit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81fcac20796e605cb1d5209e49b72fe6
https://doi.org/10.4049/jimmunol.148.7.2181

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Autor: E Vivier, N Rochet, J P Kochan, D H Presky, S F Schlossman, P Anderson

Publikováno v: The Journal of Immunology. 147:4263-4270

The TCR complex is composed of a clonotypic heterodimer (Ti alpha:beta or gamma:delta) noncovalently associated with the CD3 complex (gamma, delta, and epsilon), and with one or more disulfide-linked dimers whose components are designated zeta and et

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb113abcf1c97256628f19103bd79378
https://doi.org/10.4049/jimmunol.147.12.4263

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Production of the glycosylphosphatidylinositol-specific phospholipase D by the islets of Langerhans

Autor: Yiying Zhang, Michael A. Davitz, N. Altszuler, T. C. Tsang, Yong Guo, J. P. Kochan, Christine N. Metz

Publikováno v: Journal of Biological Chemistry. 266:17733-17736

A large number of diverse cell surface proteins are anchored to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor. One proposed function for the GPI anchor is that it facilitates the release of the protein from the cell by acting as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::881897e7bf88c808a151c131b04f67ef
https://doi.org/10.1016/s0021-9258(18)55185-1

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Recombinant human (rh)IL-4-mediated apoptosis and recombinant human IL-6-mediated protection of recombinant human stem cell factor-dependent human mast cells derived from cord blood mononuclear cell progenitors

Autor: C A, Oskeritzian, Z, Wang, J P, Kochan, M, Grimes, Z, Du, H W, Chang, S, Grant, L B, Schwartz

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(9)

Although stem cell factor (SCF) appears to be the major growth factor for human mast cells, other factors undoubtedly play important roles in the development, survival, and function of these cells. The current study examined the effects of recombinan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4894a12d28301b886280afe0e847ef45
https://pubmed.ncbi.nlm.nih.gov/10528217

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Effect of recombinant human IL-4 on tryptase, chymase, and Fc epsilon receptor type I expression in recombinant human stem cell factor-dependent fetal liver-derived human mast cells

Autor: H Z, Xia, Z, Du, S, Craig, G, Klisch, N, Noben-Trauth, J P, Kochan, T H, Huff, A M, Irani, L B, Schwartz

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 159(6)

The effect of recombinant human IL-4 (rhIL-4) on the development of recombinant human stem cell factor-dependent fetal liver-derived mast cells was examined. RhIL-4 attenuates the number of mast cells that develop, preferentially affecting the MC(T)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49802e204cd50e3ebb74e5b1e766e131
https://pubmed.ncbi.nlm.nih.gov/9300715

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