Zobrazeno 1 - 10
of 12
pro vyhledávání: '"J. P. Guare"'
Autor:
J C Quintero, Zugay Ja, Rhonda B. Levin, J. P. Guare, Stacey L. McDaniel, Bruce D. Dorsey, Joseph P. Vacca, William A. Schleif, Emilio A. Emini, Paul L. Darke
Publikováno v:
Journal of Medicinal Chemistry. 37:3443-3451
A series of HIV protease inhibitors possessing a hydroxylaminepentanamide transition state isostere have been developed. Incorporation of a basic amine into the backbone of the L-685,434 (2) series provided antiviral potency combined with a highly im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d937f742bb24ca71e0381df0eeeffaea
https://doi.org/10.1021/jm00047a001
https://doi.org/10.1021/jm00047a001
Autor:
Emilio A. Emini, Drazen Ostovic, I-W. Chen, J. P. Guare, J. H. Lin, Joel R. Huff, Paul L. Darke, Kari Vastag, P. S. Anderson, Boyoung Kim, Colleen M. Hanifin, Stuart R. Michelson, William A. Schleif, J. P. Vacca, Joan A. Zugay
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29f6851462b10bc608b0f42289c79777
https://doi.org/10.1002/chin.199517244
https://doi.org/10.1002/chin.199517244
Autor:
Emilio A. Emini, J. P. Guare, Joan A. Zugay, Paul L. Darke, Stuart R. Michelson, Joel R. Huff, P. S. Anderson, J. P. Vacca, William A. Schleif, J. H. Lin, I.-W. Chen, Boyoung Kim, Kari Vastag
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6da7943e52d2c32621d7bb5cb18dc609
https://doi.org/10.1002/chin.199524111
https://doi.org/10.1002/chin.199524111
Autor:
J. P. Guare, Zugay Ja, William A. Schleif, S J deSolms, Paul L. Darke, E A Giuliani, I S Sigal, Joseph P. Vacca, William M. Sanders, Steven D. Young
Publikováno v:
Journal of Medicinal Chemistry. 34:1225-1228
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d0b91b6388941f4b1ea4a8076bc431
https://doi.org/10.1021/jm00107a050
https://doi.org/10.1021/jm00107a050
Autor:
T A, Lyle, C M, Wiscount, J P, Guare, W J, Thompson, P S, Anderson, P L, Darke, Z A, Zugay, E A, Emini, W A, Schleif, J C, Qunitero
Publikováno v:
Journal of Medicinal Chemistry. 34:1228-1230
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761c8f2d47990a6e076dbcd845a3a833
https://doi.org/10.1021/jm00107a051
https://doi.org/10.1021/jm00107a051
Autor:
I S Sigal, S J deSolms, Zugay Ja, J. M. Wiggins, J. P. Vacca, Samuel L. Graham, J. P. Guare, E A Giuliani, William M. Sanders, Paul L. Darke
Publikováno v:
Journal of medicinal chemistry. 34(9)
A series of tetrapeptide analogues of 1 (L-682,679), in which the carboxy terminus has been shortened and modified, was prepared and their inhibitory activity measured against the HIV protease in a peptide cleavage assay. Selected examples were teste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8da6dbba186808bacd8b16f0dfec43
https://pubmed.ncbi.nlm.nih.gov/1910089
https://pubmed.ncbi.nlm.nih.gov/1910089
Autor:
P L, Darke, N E, Kohl, M G, Hanobik, C T, Leu, J P, Vacca, J P, Guare, J C, Heimbach, R A, Dixon
Publikováno v:
Advances in experimental medicine and biology. 306
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::928360640b77c9c8ce8a63c1bd412015
https://pubmed.ncbi.nlm.nih.gov/1812746
https://pubmed.ncbi.nlm.nih.gov/1812746
Autor:
J. P. Guare, B. M. Kim
Publikováno v:
HETEROCYCLES. 41:403
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7404e1061088a6d26cf08a1fd096ce8
https://doi.org/10.3987/com-94-6970
https://doi.org/10.3987/com-94-6970
Autor:
W. S. Saari, S. W. King, V. J. Lotti, Hunt Cecilia, D. A. Taylor, J. P. Guare, W. C. Randall, Wasyl Halczenko, Huff, P. S. Anderson
Publikováno v:
Journal of Medicinal Chemistry. 26:1696-1701
A series of 1-(2-pyridinyl)piperazine derivatives was synthesized and evaluated for adrenergic activity. In vitro activity was assessed through the antagonism of clonidine's effect in the rat, isolated, field-stimulated vas deferens and by the displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca44f469da71289daed502b6c85ae93
https://doi.org/10.1021/jm00366a007
https://doi.org/10.1021/jm00366a007
Autor:
Douglas J. Pettibone, P. S. Anderson, B. V. Clineschmidt, Joel R. Huff, J. P. Vacca, J. P. Guare, V. J. Lotti, John J. Baldwin, W. C. Randall
Publikováno v:
Chemischer Informationsdienst. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7493844dc78395ca3d44388282197d2
https://doi.org/10.1002/chin.198613207
https://doi.org/10.1002/chin.198613207