Zobrazeno 1 - 10
of 58
pro vyhledávání: '"J. P. Fawcett"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 7, Pp 3156-3166 (2022)
d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS, also known as vitamin E-TPGS) is a biodegradable amphiphilic polymer prepared by esterification of vitamin E with polyethylene glycol (PEG) 1000. It is approved by the US Food and Drug Adminis
Externí odkaz:
https://doaj.org/article/6ce4589a2aeb4327828ee05ac34a1ed1
Autor:
Chunsu Liang, Hui Sun, Xiangjun Meng, Lei Yin, J. Paul Fawcett, Huaidong Yu, Ting Liu, Jingkai Gu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 8, Iss 2, Pp 228-234 (2018)
Because many therapeutic agents are contaminated by epimeric impurities or form epimers as a result of metabolism, analytical tools capable of determining epimers are increasingly in demand. This article is a proof-of-principle report of a novel DMS
Externí odkaz:
https://doaj.org/article/08620b25fe3b47ed9d4f6edca3b65b63
Autor:
Yang Zhang, Yan Yang, Sen Zhao, Zhichao Yang, Hong Yang, J. Paul Fawcett, Youxin Li, Jingkai Gu, Tiemin Sun
Publikováno v:
Molecules, Vol 18, Iss 12, Pp 14920-14934 (2013)
O-Desmethylvenlafaxine (desvenlafaxine, ODV) is a recently approved antidepressant which in some clinical studies failed to meet a satisfactory end-point. The aim of this study was to prepare a series of phenolic esters of ODV and evaluate their pote
Externí odkaz:
https://doaj.org/article/2536e831fb0d4be5869842c04dcd4689
Autor:
Xiao-Jiao Li, Yan-Tong Sun, Lei Yin, Xue-Ju Zhang, Yan Yang, J. Paul Fawcett, Yi-Min Cui, Jing-Kai Gu
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 3, Iss 1, Pp 1-8 (2013)
A rapid and sensitive method based on liquid chromatographyâtandem mass spectrometry (LCâMS/MS) for the determination of a novel anticoagulant peptide bivalirudin in human plasma has been developed and validated. Plasma samples were precipitated pr
Externí odkaz:
https://doaj.org/article/da44d5eac1054072a08a31fe4b4636d3
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
During postnatal development, closure of critical periods coincides with the appearance of extracellular matrix structures, called perineuronal nets (PNN), around various neuronal populations throughout the brain. The absence or presence of PNN stron
Externí odkaz:
https://doaj.org/article/9c5c4162c75544eaa5f4cdc87fac8588
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 1, Iss 1, Pp 40-45 (2011)
A rapid and sensitive method based on high-performance liquid chromatography–tandem mass spectrometry (LC–MS/MS) has been developed for the determination of repaglinide in human plasma. The analyte and internal standard (I.S.), diazepam, were ext
Externí odkaz:
https://doaj.org/article/b5f12487cbea47e683b5bd505321ed8d
Publikováno v:
Drug Metabolism Reviews. 40:149-168
The importance of cytochrome P450 (CYP) 3A enzymes in human drug metabolism is well established. The function of these enzymes has been characterized extensively in liver and intestinal tissues but much less is known about their expression, regulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea2f7d2941649a473b93fe116892570
https://doi.org/10.1080/03602530701836712
https://doi.org/10.1080/03602530701836712
Autor:
Ksenija Kuhajda, Slavko Kevrešan, Hani Al-Salami, Svetlana Goločorbin-Kon, N. S. Boni, J. P. Fawcett, Momir Mikov
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 32:7-12
Previous studies in our laboratory have shown that the semisynthetic bile acid derivative, sodium 3α,7α-dihydroxy-12-oxo-5β-cholanate (MKC), has hypoglycemic activity. The aim of this study was to investigate the relationship between the pharmacok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8942bb8bee02af96c52be04fdffd78b2
https://doi.org/10.1007/bf03190984
https://doi.org/10.1007/bf03190984
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 31:157-177
In this article, the methods of isolation and determination of bile acids are reviewed. Methods for separation of bile acids from cattle and pig bile are given in detail. Isolation of a mixture of cholic acid and deoxycholic acids from cattle bile an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3817bdc303107cac65b4adddc0f11f
https://doi.org/10.1007/bf03190712
https://doi.org/10.1007/bf03190712
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 31:145-156
The biosynthesis of bile acids in mammalian liver and its regulation, together with the physiological role of bile acids, are reviewed in this article. Bile acids are biosynthesized from cholesterol in hepatocytes. Several steps are involved includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0442084a53dcdc697e6259d6cc57bbc
https://doi.org/10.1007/bf03190711
https://doi.org/10.1007/bf03190711