Výsledky vyhledávání - "J. P. Durkin"

Evidence that the activation of an inactive pool of membrane-associated protein kinase C is linked to the IL-2-dependent survival of T lymphocytes

Autor: Y Lu, R Tremblay, H Jouishomme, B Chakravarthy, J P Durkin

Publikováno v: The Journal of Immunology. 153:1495-1504

The activation of protein kinase C (PKC) is believed to result from the translocation of inactive cytosolic enzyme to the lipid environment of membranes. However, by using a novel method for measuring PKC activity directly in isolated membranes, we h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ee2f6385a3ede02e393ba61dbdbbb93
https://doi.org/10.4049/jimmunol.153.4.1495

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Changes in the polypeptide profiles during photoinduction of Xanthium strumarium

Autor: F. Wightman, J. P. Durkin, J. ApSimon, T. Kannangara

Publikováno v: Physiologia Plantarum. 78:519-525

The polypeptides in the leaf blades, petioles and apices from photoinduced and noninduced Xanthium strumarium L. were compared by two dimensional gel-electrophoresis. A 15 kDa and a 16 kDa polypeptide were detected in gels of the leaf blade from noni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81aeb2417df9e06ad390d297c4b830c8
https://doi.org/10.1111/j.1399-3054.1990.tb05236.x

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AR-R15896AR blocks the early NMDA-induced loss of MAP2 in primary cortical cultures

Autor: N B, Laferrière, R, Tremblay, C L, Murray, R, Monette, D L, Brown, J P, Durkin, P, Morley

Publikováno v: Neurological research. 21(5)

The low-affinity use-dependent N-methyl-D-aspartate (NMDA) receptor antagonist AR-R15896AR is neuroprotective in primary rat cortical cultures exposed to toxic concentrations of NMDA and reduces the magnitude of NMDA-triggered increases in [Ca2+]i. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::76f2a306c52ba858ac3a1fb6eac889f6
https://pubmed.ncbi.nlm.nih.gov/10439436

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Selective coupling of mu-calpain activation with the NMDA receptor is independent of translocation and autolysis in primary cortical neurons

Autor: K E, Hewitt, H J, Lesiuk, J S, Tauskela, P, Morley, J P, Durkin

Publikováno v: Journal of neuroscience research. 54(2)

Excessive mu-calpain activation has been linked to several cellular pathologies including excitotoxicity and ischemia. In erythrocytes and other non-central nervous system (CNS) cells, calpain activation is thought to occur following a Ca2+-induced t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e5c7bcb056380d135056e418f3474969
https://pubmed.ncbi.nlm.nih.gov/9788281

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Stimulation of glutamate uptake and Na,K-ATPase activity in rat astrocytes exposed to ischemia-like insults

Autor: D B, Stanimirovic, R, Ball, J P, Durkin

Publikováno v: Glia. 19(2)

The postsynaptic actions of glutamate are rapidly terminated by high affinity glutamate uptake into glial cells. In this study we demonstrate the stimulation of both glutamate uptake and Na,K-ATPase activity in rat astrocyte cultures in response to s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eb4d1baef48a5ea2f684a16e98a1c477
https://pubmed.ncbi.nlm.nih.gov/9034829

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Glutamate uptake and Na,K-ATPase activity in rat astrocyte cultures exposed to ischemia

Autor: D B, Stanimirovic, R, Ball, J P, Durkin

Publikováno v: Acta neurochirurgica. Supplement. 70

In this study we demonstrate the stimulation of both glutamate uptake and Na,K-ATPase activity in rat astrocyte cultures in response to a sublethal ischemic insult in vitro. To measure sodium pump activity and glutamate uptake, 3H-glutamate and 86Rb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb10050e1385145fba5e562081306af2
https://pubmed.ncbi.nlm.nih.gov/9416261

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Increase in surface expression of ICAM-1, VCAM-1 and E-selectin in human cerebromicrovascular endothelial cells subjected to ischemia-like insults

Autor: D B, Stanimirovic, J, Wong, A, Shapiro, J P, Durkin

Publikováno v: Acta neurochirurgica. Supplement. 70

Secondary ischemic brain injury has been shown to develop as a consequence of inflammation and vasogenic brain edema. In this study we show that inflammatory cytokines and simulated in vitro ischemia stimulate the surface expression of intercellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::94c8ecd20581ac29a527c2de862d0c88
https://pubmed.ncbi.nlm.nih.gov/9416264

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Glucose, potassium, and CCK-8 induce increases in membrane-associated PKC activity that correspond to increases in [Ca2+]i in islet cells from neonatal rats

Autor: J, Wang, B R, Chakravarthy, P, Morley, J F, Whitfield, J P, Durkin, N, Bégin-Heick

Publikováno v: Cellular signalling. 8(4)

The effects of glucose, K+, and cholecystokinin octapeptide (CCK-8) on intracellular free Ca2+ concentration ([Ca2+]i) and membrane-associated protein kinase C (PKC) activity were examined in cultured islet cells from neonatal rats. Raising the gluco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a8b2226a14ba37a3d92a1f2cc0d0ecc
https://pubmed.ncbi.nlm.nih.gov/8842532

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Stimulation of protein kinase C during Ca(2+)-induced keratinocyte differentiation. Selective blockade of MARCKS phosphorylation by calmodulin

Autor: B R, Chakravarthy, R J, Isaacs, P, Morley, J P, Durkin, J F, Whitfield

Publikováno v: The Journal of biological chemistry. 270(3)

Raising the external Ca2+ concentration from 0.05 to 1.8 mM stimulated membrane-associated protein kinase Cs (PKCs) activity as strongly as the specific PKCs activator, 12-O-tetradecanoyl phorbol-13-acetate (TPA) in BALB/MK mouse keratinocytes. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8dfe2bca6cc11fee5ceedf4775f7f565
https://pubmed.ncbi.nlm.nih.gov/7836403

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