Zobrazeno 1 - 10
of 130
pro vyhledávání: '"J. P. Clozel"'
Publikováno v:
Xenobiotica. 26:333-345
1. An hplc method with fluorescence derivatization was developed for the quantification of remikiren in plasma (limit of quantification 2 ng/ml). This was used to determine the pharmacokinetics in various species of primate, in which the compound is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f53e7cfb561b4fe94c7e0d0e1031b4
https://doi.org/10.3109/00498259609046712
https://doi.org/10.3109/00498259609046712
Publikováno v:
Journal of Cardiovascular Pharmacology. 18:S55-S58
Ro 40-5967 is a new calcium antagonist that binds to the same site as verapamil but that has been shown to have a much lesser negative inotropic effect than verapamil. The goal of the present study was to assess the hemodynamic profile of Ro 40-5967
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56f852682d6710da308d8f4adf26840
https://doi.org/10.1097/00005344-199118101-00010
https://doi.org/10.1097/00005344-199118101-00010
Publikováno v:
The Journal of Physiology. 428:215-232
1. Veratridine injected into the coronary circulation stimulates afferent vagal endings in the heart to evoke bradycardia and systemic hypotension (Bezold-Jarisch reflex, coronary chemoreflex) and coronary vasodilation. We have examined certain featu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf23ac1d0b7b93492a233807bc01e91
https://doi.org/10.1113/jphysiol.1990.sp018208
https://doi.org/10.1113/jphysiol.1990.sp018208
Publikováno v:
Acta pharmacologica Sinica. 22(6)
To evaluate the acute effects of tezosentan, a new dual parenteral endothelin receptor antagonist, on hemodynamics in a rat model of chronic heart failure (CHF), and further investigated if the combination of tezosentan with the angiotensin convertin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc3c54bc49a363c0e213e6e5718a6495
https://pubmed.ncbi.nlm.nih.gov/11747762
https://pubmed.ncbi.nlm.nih.gov/11747762
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(2)
Tezosentan (Ro 61-0612) [5-isopropyl-pyridine-2-sulfonic acid 6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-1H-tetrazol-5-yl-+ ++pyri din-4-yl)-pyrimidin-4-ylamide] is a new endothelin (ET) receptor antagonist specifically designed for parenteral u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::147e1c57d12f96739f5189fb5184e644
https://pubmed.ncbi.nlm.nih.gov/10411600
https://pubmed.ncbi.nlm.nih.gov/10411600
Autor:
Fiona Grüninger, Fritz K. Winkler, Georges Hirth, Eric Vieira, Wolfgang Wostl, Arnulf Dorn, H Stadier, Marcel Muller, Allan D'Arcy, Daniel Bur, J-P. Clozel, Walter Fischli, Volker Breu, Christian Oefner, Alfred Binggeli, Robert G. Ridley, Rolf Güller, Maerki Hans-Peter, Salima Mathews, Maurice Wilhelm
Publikováno v:
Chemistrybiology. 6(3)
Background The aspartic proteinase renin catalyses the first and rate-limiting step in the conversion of angiotensinogen to the hormone angiotensin II, and therefore plays an important physiological role in the regulation of blood pressure. Numerous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8811cf76cd0365551eb4117a96262ef
https://pubmed.ncbi.nlm.nih.gov/10074464
https://pubmed.ncbi.nlm.nih.gov/10074464
Publikováno v:
Cardiovascular drugs and therapy. 11(6)
Low-voltage-activated T-type Ca2+ channels are present in most excitable tissues including the heart (mainly pacemaker cells), smooth muscle, central and peripheral nervous systems, and endocrine tissues, but also in non-excitable cells, such as oste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6cb9c4c83d264dbc5e81163882607f62
https://pubmed.ncbi.nlm.nih.gov/9512867
https://pubmed.ncbi.nlm.nih.gov/9512867
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 283(3)
Endothelin (ET) receptor antagonists are of great potential clinical interest for the treatment pathological conditions associated with vasospasm, such as subarachnoid hemorrhage (SAH). We developed for parenteral use a compound of a class of trifunc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9856bcfaa9beffc3846cb2f303ececf
https://pubmed.ncbi.nlm.nih.gov/9399983
https://pubmed.ncbi.nlm.nih.gov/9399983
Publikováno v:
Cardiovascular research. 31(2)
Recent studies have shown that beside elevated arterial blood pressure, humoral factors such as angiotensin II, aldosterone, endothelin or bradykinin might play a role in the cardiac hypertrophy and fibrosis secondary to hypertension. In addition, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e3d1bf6e1e787f8ec8745eeefddd2cd4
https://pubmed.ncbi.nlm.nih.gov/8730406
https://pubmed.ncbi.nlm.nih.gov/8730406
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 274(1)
Rhabdomyolysis and other causes of massive myoglobin release are often complicated by an acute ischemic renal failure. We tested the hypothesis that endothelin-1, the most potent renal vasoconstrictor known, plays a role in the renal toxicity of myog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91c497be73ac0f1a244c0bf0d7734e76
https://pubmed.ncbi.nlm.nih.gov/7616435
https://pubmed.ncbi.nlm.nih.gov/7616435