Zobrazeno 1 - 10
of 85
pro vyhledávání: '"J. P. Chapat"'
Autor:
T. M. Pocock, J. P. Chapat, Karine Portet, Guy Subra, Pierre-Antoine Bonnet, Alain Michel, Veronique Benezech, Olivier Vitse, Lahcen Zanik, Roger C. Small, F. Laurent, Keith R.F. Elliott, J. Bompart
Publikováno v:
Bioorganic & Medicinal Chemistry. 7:1059-1065
New imidazo[1,2-a]pyrazine derivatives have been synthesized either by direct cyclization from pyrazines or by electrophilic substitutions. The presence of electron donating groups on position 8 greatly enhances the reactivity of the heterocycle towa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d711c5a72f26437b781d44251ae82f26
https://doi.org/10.1016/s0968-0896(99)00019-x
https://doi.org/10.1016/s0968-0896(99)00019-x
Autor:
J. P. Chapat, Yves Blache, A. Voldoire, Marie-Eve Sinibaldi-Troin, Jean-Claude Gramain, Olivier Chavignon, Jean-Claude Teulade
Publikováno v:
The Journal of Organic Chemistry. 62:8553-8556
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c28e87e47ced54277ddc893606313d48
https://doi.org/10.1021/jo970637+
https://doi.org/10.1021/jo970637+
Autor:
H. Viols, J. P. Chapat, J. Bompart, Guy Subra, Gérard Grassy, Olivier Vitse, Pierre-Antoine Bonnet
Publikováno v:
Journal of Heterocyclic Chemistry. 34:701-707
Nitration was carried out on a series of imidazo[1,2-a]pyrazine derivatives. The reactivities of diversely substituted derivatives and of all positions of substitution were analysed and experimental results compared with 13-nmr data and semi empirica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99ba81d461c2240dd6779e055a91e346
https://doi.org/10.1002/jhet.5570340301
https://doi.org/10.1002/jhet.5570340301
Autor:
Olivier Chavignon, Yves Blache, Florence Fauvelle, Gérard Dauphin, Alain Gueiffier, J. P. Chapat, H. Viols, Jean C. Teulade, Gérard Grassy
Publikováno v:
Journal of Heterocyclic Chemistry. 34:765-771
The synthesis and reactivity of imidazo[1,2-a][1,8]naphthyridines are reported. Electrophilic substitution reactions were studied and the site of the reaction was established with the aid of high-field 1H and 13C nmr spectra. The experimental C-1 pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1837e062cf90f678de580794cc3e8b96
https://doi.org/10.1002/jhet.5570340311
https://doi.org/10.1002/jhet.5570340311
Autor:
Gérard Dauphin, A. Gueiffier, H. Viols, Yves Blache, J. P. Chapat, J. C. Milhavet, Olivier Chavignon, J. C. Teulade
Publikováno v:
Journal of Heterocyclic Chemistry. 31:161-166
In this paper, we report the results of heterocyclizations in the pyrido[2,3-b]pyrazine series to give the pyrido[2,3-e] or [3,2-e]pyrrolo[1,2-a]pyrazine. The Clauson-Kaas reaction on 2,3-diaminopyridine is investigated; regioselectivity on the 3-ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2853afec59466393a8edc1e389f6641
https://doi.org/10.1002/jhet.5570310127
https://doi.org/10.1002/jhet.5570310127
Autor:
Patrick Vallet, Jean P. Fernandez, G. Subra, Aziz Chaouni-Benabdallah, Robert N. Muller, J. P. Chapat, Pierre Bonnet
Publikováno v:
Tetrahedron. 50:12923-12932
The synthesis of new but unstable α-(hydroxymethyl)oxazolidin-3-oxyls was achieved after protection by silylation of the hydroxyl groups in order to avoid decomposition in diamagnetic nitrones. Relaxivity studies of (R,S)-4-(hydroxymethyl)-2,2,4-tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a73040d263fe0bc0b216a9fd59f6af12
https://doi.org/10.1016/s0040-4020(01)81211-4
https://doi.org/10.1016/s0040-4020(01)81211-4
Autor:
Olivier Chavignon, J. P. Chapat, H. Viols, Jean C. Teulade, Alain Gueiffier, M. Madesclaire, Yves Blache, Gérard Dauphin, J. C. Milhavet
Publikováno v:
ChemInform. 22
The reaction of nitrosyl chloride with 6- and 8-acetamido-7-methylimidazo[1, 2-a]pyridine (7g-i) reveal clear differences of reactivity of these isomeric structures. After bifunctionalization of the imidazolic moiety, the 6-acetamido derivatives do n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b25241487f69c59e953f9b06124e3c3c
https://doi.org/10.1002/chin.199118179
https://doi.org/10.1002/chin.199118179
Autor:
N. Madadi, Jean-Claude Teulade, Michel P. Crozet, J. P. Chapat, José Maldonado, Alain Gueiffier, Patrice Vanelle
Publikováno v:
ChemInform. 22
2-Chloromethyl-3-nitroimidazo[1,2-a]pyridine is shown for the first time to react with 2-nitropropane salts by an SRN1 mechanism to give excellent yield of isopropylidene derivative formed from the C-alkylation product by loss of nitrous acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f75e0255081f5bb8be1c4a721315a7c7
https://doi.org/10.1002/chin.199123158
https://doi.org/10.1002/chin.199123158
Autor:
Jean-Claude Teulade, J. P. Chapat, H. Viols, Gérard Dauphin, Olivier Chavignon, M. Madesclaire, Yves Blache, Alain Gueiffier
Publikováno v:
ChemInform. 23
A general synthesis for the preparation of a series of N-bridgehead compounds: pyrroloimidazopyridine, pyrimidine and naphthyridine has been developed beginning with azidovinyl compounds with thermolytic or photochemical methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22bce5e228273595d278b58ba946e827
https://doi.org/10.1002/chin.199248086
https://doi.org/10.1002/chin.199248086
Autor:
Alain Michel, C. Sablayrolles, Jean C. Mani, Maurice Boucard, J. P. Chapat, Eliane Rechencq, Pierre-Antoine Bonnet, F. Laurent
Publikováno v:
ChemInform. 24
Theophylline still occupies a dominant place in asthma therapy. Unfortunately its adverse central nervous system (CNS) stimulant effects can dramatically limit its use, and adjustments in the dosage are often needed. We have synthesized a new series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::812f7b1f5d3b552fc20a19239940c668
https://doi.org/10.1002/chin.199301213
https://doi.org/10.1002/chin.199301213