Zobrazeno 1 - 10
of 12
pro vyhledávání: '"J. Owen McCall"'
Autor:
Tianyuan Zhang, Richard A. G. Smith, Rohinton Edalji, Yu-Gui Gu, John L. Baranowski, William J. Sanders, Bruce A. Beutel, Liping Yu, Philip J. Hajduk, Annapur Gurulingappa Shivakumar, Stephan J. Kakavas, Frank L. Wagenaar, Darlene J. Balli, Steven F. Betz, Richard F. Clark, Kenneth M. Comess, Eric J. Hebert, J. Owen McCall, Jamey Mack, Linda E. Chovan, Randy E. Metzger, Thomas F. Holzman, Anne Y. Saiki, Sarah A. Dorwin, Niru B. Soni, Mai Bui, Angela M. Nilius, Susan J. Thornewell, Cooper Curt S, Mark E. Schurdak, Michael L. Coen, Rolf Wagner, Alan S. Florjancic, Philip J. Merta, Claude G. Lerner, Charlotte Woodall, Candace Black-Schaefer, John E. Harlan, Mengli Cai, Karl A. Walter, Xenia B. Searle, Stephen W. Fesik
Publikováno v:
Chemical Biology & Drug Design. 69:395-404
As part of a fully integrated and comprehensive strategy to discover novel antibacterial agents, NMR- and mass spectrometry-based affinity selection screens were performed to identify compounds that bind to protein targets uniquely found in bacteria
Autor:
Stephen F. Betz, Kevin Ronald Condroski, John E. Harlan, Bruce A. Beutel, Jean M. Severin, Sean M. Merrick, Vicki L. Nienaber, Susan J. Swanson, Rolf Wagner, Vincent S. Stoll, Karl A. Walter, J. Owen McCall, Peter Magdalinos, Claude G. Lerner, William J. Sanders, Geoffrey F. Stamper, Clarissa G. Jakob, Robert P. Meadows
Publikováno v:
Journal of Medicinal Chemistry. 47:1709-1718
Potent inhibitors of 7,8-dihydroneopterin aldolase (DHNA; EC 4.1.2.25) have been discovered using CrystaLEAD X-ray crystallographic high-throughput screening followed by structure-directed optimization. Screening of a 10 000 compound random library p
Autor:
Katrin E. Rhodes, Patrick A. Marcotte, Yujia Dai, Eric F. Johnson, Jun Guo, Michael R. Michaelides, Saul J. Priceman, Lori J. Pease, Niru B. Soni, Theodore B. Moore, Jenny Chang, Kathleen M. Sakamoto, Steven K. Davidsen, Ru-Qi Wei, Keith B. Glaser, Deepa B. Shankar, Jennifer J. Bouska, Junling Li, Paul Tapang, Daniel H. Albert, Neil P. Shah, Kresna Hartandi, J. Owen McCall, Donald J. Osterling
In 15% to 30% of patients with acute myeloid leukemia (AML), aberrant proliferation is a consequence of a juxtamembrane mutation in the FLT3 gene (FMS-like tyrosine kinase 3–internal tandem duplication [FLT3-ITD]), causing constitutive kinase activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c83ec4de1219dc2e704f8d60cb6299
https://resolver.caltech.edu/CaltechAUTHORS:20100219-111915402
https://resolver.caltech.edu/CaltechAUTHORS:20100219-111915402
Autor:
Mark E. Schurdak, Lan Gao, Claude G. Lerner, Houjun Yang, Jonathan D. Trumbull, Hua Tang, David J. Burns, Xueheng Cheng, Bruce A. Beutel, J. Owen McCall, Michael L. Coen, Kenneth M. Comess, Martin J. Voorbach
Publikováno v:
Journal of biomolecular screening. 11(7)
The authors describe the discovery of a new class of inhibitors to an essential Streptococcus pneumoniae cell wall biosynthesis enzyme, MurF, by a novel affinity screening method. The strategy involved screening very large mixtures of diverse small o
Autor:
Nayereh S. Ghoreishi-Haack, Junling Li, Baole Wang, J. Owen McCall, Steven K. Davidsen, Lori J. Pease, Paul Tapang, Daniel H. Albert, Yi-Chun Wang, Nirupama B. Soni, Peter F. Bousquet, Amanda Niquette, David R. Reuter, Cherrie K. Donawho, Patrick A. Marcotte, Yanping Luo, Kresna Hartandi, Eric F. Johnson, Gail Bukofzer, Jason Stavropoulos, Jun Guo, Michael R. Michaelides, Jennifer J. Bouska, Terrance J. Magoc, Ru-Qi Wei, Keith B. Glaser, Yujia Dai
Publikováno v:
Molecular cancer therapeutics. 5(4)
ABT-869 is a structurally novel, receptor tyrosine kinase (RTK) inhibitor that is a potent inhibitor of members of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor families (e.g., KDR IC50 = 4 nmol/L) b
Autor:
J. Owen McCall, Bruce A. Beutel, Philip J. Hajduk, Geoffrey F. Stamper, Richard F. Clark, Yingna Cia, Kenton L. Longenecker, Elizabeth H. Fry, Candace Black-Schaefer, Clarissa G. Jakob, Cooper Curt S, Alan S. Florjancic, Claude G. Lerner, Vincent S. Stoll, Yu-Gui Gu, David D. Anderson, Tianyuan Zhang
Publikováno v:
Chemical biologydrug design. 67(1)
The D-Ala-D-Ala adding enzyme (MurF) from Streptococcus pneumoniae catalyzes the ATP-dependent formation of the UDP-MurNAc-pentapeptide, a critical component of the bacterial cell wall. MurF is a potential target for antibacterial design because it i
Autor:
J. Owen McCall, Claude G. Lerner, Tianyuan Zhang, Cooper Curt S, Richard F. Clark, Geoffrey F. Stamper, Yingna Cai, Candace Black-Schaefer, David D. Anderson, Philip J. Hajduk, Yu Gui Gu, Alan S. Florjancic, Bruce A. Beutel
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(1)
A novel class of MurF inhibitors was discovered and structure-activity relationship studies have led to several potent compounds with IC(50)=22 approximately 70 nM. Unfortunately, none of these potent MurF inhibitors exhibited significant antibacteri
Publikováno v:
Bio/Technology (Nature Publishing Company)
We have developed a high capacity screen for compounds that inhibit the 3C protease of human rhinovirus–1b. The assay uses a recombinant strain of Escherichia coli expressing both the protease and a tetracycline resistance–conferring protein modi
Publikováno v:
Moleculargeneral genetics : MGG. 185(1)
Cellular activities normally inducible by DNA damage (SOS functions) are expressed, without DNA damage, in recA441 (formerly tif-1) mutants of Escherichia coli at 42 degrees C but not at 30 degrees C. We describe a strain (SC30) that expresses SOS fu
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