Chlamydia (lymphogranuloma venereum) peritonitis in a male patient

Autor: Magdalena Antonik, C. Briggs, Katie J Ovens, Peter L. Labib

Publikováno v: BMJ Case Rep

A 49-year-old man presented with a 1-week history of abdominal pain, distension, diarrhoea and fatigue. CT of the abdomen and pelvis revealed peritonitis with no identifiable cause. Diagnostic laparoscopy was performed, which excluded gastrointestina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d7611a101ae621b024cba65ce55372
https://pubmed.ncbi.nlm.nih.gov/33853816

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

Autor: Ashley J. Ovens, Yi Sing Gee, Naomi X.Y. Ling, Dingyi Yu, Justin P. Hardee, Jin D. Chung, Kevin R.W. Ngoei, Nicholas J. Waters, Nolan J. Hoffman, John W. Scott, Kim Loh, Katrin Spengler, Regine Heller, Michael W. Parker, Gordon S. Lynch, Fei Huang, Sandra Galic, Bruce E. Kemp, Jonathan B. Baell, Jonathan S. Oakhill, Christopher G. Langendorf

Publikováno v: The Biochemical journal. 479(11)

The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy sensor and central regulator of energy homeostasis. Activating skeletal muscle AMPK with small molecule drugs improves glucose uptake and provides an opportunity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af622cb195c6973f7a65b699182f0e7
https://pubmed.ncbi.nlm.nih.gov/35552369

Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis

Autor: Katyayanee Neopane, Natalie Kozlov, Florentina Negoita, Lisa Murray-Segal, Robert Brink, Ashfaqul Hoque, Ashley J. Ovens, Gavin Tjin, Luke M. McAloon, Dingyi Yu, Naomi X.Y. Ling, Matthew J. Sanders, Jonathan S. Oakhill, John W. Scott, Gregory R. Steinberg, Kim Loh, Bruce E. Kemp, Kei Sakamoto, Sandra Galic

Publikováno v: Neopane, K, Kozlov, N, Negoita, F, Murray-Segal, L, Brink, R, Hoque, A, Ovens, A J, Tjin, G, McAloon, L M, Yu, D, Ling, N X Y, Sanders, M J, Oakhill, J S, Scott, J W, Steinberg, G R, Loh, K, Kemp, B E, Sakamoto, K & Galic, S 2022, ' Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis ', Cell Reports, vol. 41, no. 12, 111862 . https://doi.org/10.1016/j.celrep.2022.111862

AMP-activated protein kinase (AMPK) is a master regulator of cellular energy homeostasis and a therapeutic target for metabolic diseases. Co/post-translational N-myristoylation of glycine-2 (Gly2) of the AMPK β subunit has been suggested to regulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785ffb05621c50ca77add3fec7ae522a
https://curis.ku.dk/ws/files/333631148/1_s2.0_S2211124722017582_main.pdf

Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle

Autor: Eric M. Desjardins, Gregory R. Steinberg, Pascal Maire, Patrick Descombes, Qian Ouyang, Danial Ahwazi, Niels Jessen, Matthew J. Sanders, Jonathan S. Oakhill, Jonas T. Treebak, Philipp Rhein, Ping Rong, Mathieu Membrez, Nicolas Bonhoure, Ashley J. Ovens, Kei Sakamoto, Amy M. Ehrlich, Jens Stolte, John W. Scott, Shuai Chen, José L. Sanchez Garcia, Matthieu Dos Santos, Mads Fuglsang Kjølby

Objective: The metabolic master-switch AMP-activated protein kinase (AMPK) mediates insulin-independent glucose uptake in muscle and regulates the metabolic activity of brown and beige adipose tissue (BAT). The regulatory AMPKγ3 isoform is uniquely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab11ba7f5930f9235d91e73faf20779a
https://doi.org/10.1101/2021.03.05.433354

Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle

Autor: Jonathan S. Oakhill, Qian Ouyang, Mads Kjolby, Jens Stolte, John W. Scott, Ashley J. Ovens, Mathieu Membrez, Niels Jessen, Amy M. Ehrlich, Julian M. Yabut, Eric M. Desjardins, Shuai Chen, Jonas T. Treebak, Pascal Maire, Danial Ahwazi, Ping Rong, Philipp Rhein, José L. Sanchez Garcia, Kei Sakamoto, Gregory R. Steinberg, Patrick Descombes, Matthew J. Sanders, Nicolas Bonhoure, Matthieu Dos Santos

Publikováno v: Rhein, P, Desjardins, E M, Rong, P, Ahwazi, D, Bonhoure, N, Stolte, J, Santos, M D, Ovens, A J, Ehrlich, A M, Sanchez Garcia, J L, Ouyang, Q, Yabut, J M, Kjolby, M, Membrez, M, Jessen, N, Oakhill, J S, Treebak, J T, Maire, P, Scott, J W, Sanders, M J, Descombes, P, Chen, S, Steinberg, G R & Sakamoto, K 2021, ' Compound-and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle ', Molecular Metabolism, vol. 51, 101228 . https://doi.org/10.1016/j.molmet.2021.101228
Molecular Metabolism
Molecular Metabolism, Vol 51, Iss, Pp 101228-(2021)
Rhein, P, Desjardins, E M, Rong, P, Ahwazi, D, Bonhoure, N, Stolte, J, Santos, M D, Ovens, A J, Ehrlich, A M, Sanchez Garcia, J L, Ouyang, Q, Yabut, J M, Kjolby, M F, Membrez, M, Jessen, N, Oakhill, J S, Treebak, J T, Maire, P, Scott, J W, Sanders, M J, Descombes, P, Chen, S, Steinberg, G R & Sakamoto, K 2021, ' Compound-and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle ', Molecular Metabolism, vol. 51, 101228 . https://doi.org/10.1016/j.molmet.2021.101228

Objective The metabolic master-switch AMP-activated protein kinase (AMPK) mediates insulin-independent glucose uptake in muscle and regulates the metabolic activity of brown and beige adipose tissue (BAT). The regulatory AMPKγ3 isoform is uniquely e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4278f7f47cec68c420f9710104a116
https://curis.ku.dk/ws/files/276699251/1_s2.0_S2212877821000739.pdf