Zobrazeno 1 - 10
of 260
pro vyhledávání: '"J. Orihuela"'
Autor:
Jessica R. Lane, Muralidhar Tata, Rahena Yasmin, Hansol Im, David E. Briles, Carlos J. Orihuela
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTStreptococcus pneumoniae (Spn) resides in the nasopharynx, where it can disseminate to cause disease. One key Spn virulence factor is pneumococcal surface protein A (PspA), which promotes survival by blocking the antimicrobial peptide lactofe
Externí odkaz:
https://doaj.org/article/fe7d0f059a4b4fff9461f59699c1eb8e
Publikováno v:
Pneumonia, Vol 15, Iss 1, Pp 1-20 (2023)
Abstract Streptococcus pneumoniae (Spn) is a major public health problem, as it is a main cause of otitis media, community-acquired pneumonia, bacteremia, sepsis, and meningitis. Acute episodes of pneumococcal disease have been demonstrated to cause
Externí odkaz:
https://doaj.org/article/c64cf7517bb743b7996eb575deae482a
Autor:
Michael John Patton, Carlos J. Orihuela, Kevin S. Harrod, Mohammad A. N. Bhuiyan, Paari Dominic, Christopher G. Kevil, Daniel Fort, Vincent X. Liu, Maha Farhat, Jonathan L. Koff, Charitharth V. Lal, Anuj Gaggar, Robert P. Richter, Nathaniel Erdmann, Matthew Might, Amit Gaggar
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-12 (2023)
Abstract Background Recent single-center reports have suggested that community-acquired bacteremic co-infection in the context of Coronavirus disease 2019 (COVID-19) may be an important driver of mortality; however, these reports have not been valida
Externí odkaz:
https://doaj.org/article/08100dfe0b7b44c1ad101bf1bafeb813
Autor:
Erin Y. Earnhardt, Jennifer L. Tipper, Adonis D’Mello, Ming-Yuan Jian, Elijah S. Conway, James A. Mobley, Carlos J. Orihuela, Hervé Tettelin, Kevin S. Harrod
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Influenza A virus (IAV) infection is commonly complicated by secondary bacterial infections that lead to increased morbidity and mortality. Our recent work demonstrates that IAV disrupts airway homeostasis, leading to airway pathophysiology resemblin
Externí odkaz:
https://doaj.org/article/7e87c160e938464ba226cadb630cb6cf
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Pf is a filamentous bacteriophage integrated in the chromosome of most clinical isolates of Pseudomonas aeruginosa. Under stress conditions, mutations occurring in the Pf genome result in the emergence of superinfective variants of Pf (SI-Pf
Externí odkaz:
https://doaj.org/article/8a11f9f3075645a0afbbaa97565c3ef3
Autor:
Hansol Im, Madison L Pearson, Eriel Martinez, Kyle H Cichos, Xiuhong Song, Katherine L Kruckow, Rachel M Andrews, Elie S Ghanem, Carlos J Orihuela
Publikováno v:
PLoS Biology, Vol 21, Iss 3, p e3002020 (2023)
Anaerobic bacteria are responsible for half of all pulmonary infections. One such pathogen is Streptococcus pneumoniae (Spn), a leading cause of community-acquired pneumonia, bacteremia/sepsis, and meningitis. Using a panel of isogenic mutants defici
Externí odkaz:
https://doaj.org/article/5ab20eff5fc54bd384eb989e2c7512bf
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Streptococcus pneumoniae (Spn), or the pneumococcus, is a Gram-positive bacterium that colonizes the upper airway. Spn is an opportunistic pathogen capable of life-threatening disease should it become established in the lungs, gain access to the bloo
Externí odkaz:
https://doaj.org/article/1493bbdedf284a0aad4caa0533d8eb8d
Autor:
David Carreno, Joseph J Wanford, Zydrune Jasiunaite, Ryan G. Hames, Wen Y Chung, Ashley R. Dennison, Kornelis Straatman, Luisa Martinez-Pomares, Manish Pareek, Carlos J. Orihuela, Marcos I. Restrepo, Wei Shen Lim, Peter W. Andrew, E. Richard Moxon, Marco R Oggioni
Publikováno v:
EBioMedicine, Vol 72, Iss , Pp 103601- (2021)
Background: Severe community-acquired pneumococcal pneumonia is commonly associated with bacteraemia. Although it is assumed that the bacteraemia solely derives from pneumococci entering the blood from the lungs it is unknown if other organs are impo
Externí odkaz:
https://doaj.org/article/e46599f8a665416fbe5eedc6ff8f5c32
Autor:
Terry Brissac, Eriel Martínez, Katherine L. Kruckow, Ashleigh N. Riegler, Feroze Ganaie, Hansol Im, Sayan Bakshi, Nicole M. Arroyo-Diaz, Brady L. Spencer, Jamil S. Saad, Moon H. Nahm, Carlos J. Orihuela
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Streptococcus pneumoniaeSpnSpn
Externí odkaz:
https://doaj.org/article/9ce4442b4bb54ebd8049a3b39250c14b
Autor:
Sang-Sang Park, Norberto Gonzalez-Juarbe, Ashleigh N. Riegler, Hansol Im, Yvette Hale, Maryann P. Platt, Christina Croney, David E. Briles, Carlos J. Orihuela
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109267- (2021)
Summary: Streptococcus pneumoniae (Spn) alone and during co-infection with influenza A virus (IAV) can result in severe pneumonia with mortality. Pneumococcal surface protein A (PspA) is an established virulence factor required for Spn evasion of lac
Externí odkaz:
https://doaj.org/article/3747f4cbc1c44c48a679527ec403ada2