Výsledky vyhledávání

Akademický článek

The Current State-of-the-Art Identification of Unknown Proteins Using Mass Spectrometry Exemplified on De Novo Sequencing of a Venom Protease from Bothrops moojeni

Autor: Simone König, Wolfgang M. J. Obermann, Johannes A. Eble

Publikováno v: Molecules, Vol 27, Iss 15, p 4976 (2022)

(1) Background: The amino acid sequence elucidation of peptides from the gas phase fragmentation mass spectra, de novo sequencing, is a valuable method for the identification of unknown proteins complementary to Edman sequencing. It is increasingly u

Externí odkaz: https://doaj.org/article/3acf8b963f064e1f912bd51279ffa91c

Zobrazit plný text záznamu

Akademický článek

Platelets, Constant and Cooperative Companions of Sessile and Disseminating Tumor Cells, Crucially Contribute to the Tumor Microenvironment

Autor: Wolfgang M. J. Obermann, Katrin Brockhaus, Johannes A. Eble

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Although platelets and the coagulation factors are components of the blood system, they become part of and contribute to the tumor microenvironment (TME) not only within a solid tumor mass, but also within a hematogenous micrometastasis on its way th

Externí odkaz: https://doaj.org/article/2b7b0e3d90ff4681b2963e63334c5466

Zobrazit plný text záznamu

Akademický článek

A primate specific extra domain in the molecular chaperone Hsp90.

Autor: Vishwadeepak Tripathi, Wolfgang M J Obermann

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e71856 (2013)

Hsp90 (heat shock protein 90) is an essential molecular chaperone that mediates folding and quality control of client proteins. Many of them such as protein kinases, steroid receptors and transcription factors are involved in cellular signaling proce

Externí odkaz: https://doaj.org/article/2ad1e8c45cba4bc982c5cf6a02bb1cab

Zobrazit plný text záznamu

A motif in HSP90 and P23 that links molecular chaperones to efficient estrogen receptor α methylation by the lysine methyltransferase SMYD2

Autor: Wolfgang M. J. Obermann

Heat shock protein 90 (HSP90) is a molecular chaperone that supervises folding of cellular signaling proteins such as steroid receptors and many protein kinases. HSP90 relies on ATP hydrolysis for powering a conformational circuit that helps fold the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352ba3219d31c179b85616ec197aaa08
https://europepmc.org/articles/PMC6200951/

Zobrazit plný text záznamu

Identifying Inhibitors of the Hsp90-Aha1 Protein Complex, a Potential Target to Drug Cystic Fibrosis, by Alpha Technology

Autor: Wolfgang M. J. Obermann, Verena Ihrig

Publikováno v: SLAS discovery : advancing life sciences RD. 22(7)

Deletion of a single phenylalanine residue at position 508 of the protein CFTR (cystic fibrosis transmembrane conductance regulator), a chloride channel in lung epithelium, is the most common cause for cystic fibrosis. As a consequence, folding of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe2fb02f1b57ae87bdd7e1003d37f4d
https://pubmed.ncbi.nlm.nih.gov/28346090

Zobrazit plný text záznamu

Aha1 Can Act as an Autonomous Chaperone to Prevent Aggregation of Stressed Proteins

Autor: Stefanie Darnauer, Wolfgang M. J. Obermann, Vishwadeepak Tripathi, Nadine R. Hartwig

Publikováno v: Journal of Biological Chemistry. 289:36220-36228

Aha1 (activator of Hsp90 ATPase) stimulates the ATPase activity of the molecular chaperone Hsp90 to accelerate the conformational cycle during which client proteins attain their final shape. Thereby, Aha1 promotes effective folding of Hsp90-dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1daecf00d07d3204376ca6cbe203a29d
https://doi.org/10.1074/jbc.m114.590141

Zobrazit plný text záznamu

Enhanced Nanoparticle Response From Coupled Dipole Excitation for Plasmon Sensors

Autor: B. Harbin, P. Blake, J. Obermann, D. K. Roper

Publikováno v: IEEE Sensors Journal. 11:3332-3340

Regular lattices of metallic nanoparticles exhibit extraordinary spectral features that arise from electromagnetic coupling between the dipole component of localized surface plasmons and constructive interference from diffracted far-field radiation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1af2d522f46cc9c106d77b5f5423f627
https://doi.org/10.1109/jsen.2011.2158417

Zobrazit plný text záznamu

Expression of Hsp90 chaperome proteins in human tumor tissue

Autor: R. Bryan Sutton, Wolfgang M. J. Obermann, Christina L. McDowell

Publikováno v: International Journal of Biological Macromolecules. 45:310-314

The activity of many oncogenic proteins depends on the molecular chaperone Hsp90. Recent studies indicate that tumorigenesis is associated with increased expression of chaperones, such as Hsp90. However, little is known about the isoform dependence a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6acfa1306878fcccf6b1b66a85f0d547
https://doi.org/10.1016/j.ijbiomac.2009.06.012

Zobrazit plný text záznamu