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Aspirin inhibits TGFβ2-induced epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3

Autor: Andrew J. O. Smith, Ram H. Nagaraj, Ko Uoon Park, I. Michael Wormstone, Mina B. Pantcheva, Mi-Hyun Nam, Joseph A. Brzezinski, James J. Galligan, Kristofer S. Fritz

Publikováno v: Biochem J

Posterior capsule opacification (PCO) is a complication after cataract surgery that can disrupt vision. The epithelial to mesenchymal transition (EMT) of lens epithelial cells (LECs) in response to transforming growth factor β2 (TGFβ2) has been con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef21cdf64e773c25e1099bbe33c34d6c
https://doi.org/10.1042/bcj20190540

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Posterior capsule opacification: What's in the bag?

Autor: Andrew J. O. Smith, I.M. Wormstone, Y.M. Wormstone, Julie A. Eldred

Cataract, a clouding of the lens, is the most common cause of blindness in the world. It has a marked impact on the wellbeing and productivity of individuals and has a major economic impact on healthcare providers. The only means of treating cataract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49cffe8729f47c5433d7cbb65b4d9d4
https://ueaeprints.uea.ac.uk/id/eprint/76999/

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Resveratrol Inhibits Wound Healing and Lens Fibrosis: A Putative Candidate for Posterior Capsule Opacification Prevention

Autor: I. Michael Wormstone, Julie A. Eldred, Andrew J. O. Smith

Publikováno v: Investigative ophthalmologyvisual science. 60(12)

Posterior capsule opacification (PCO) is a common complication of cataract surgery. In addition to improved surgical methods and IOL designs, it is likely additional agents will be needed to improve patient outcomes. Presently no pharmacological agen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60a7b310f2c523517911561c90257b3
https://pubmed.ncbi.nlm.nih.gov/31529119

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AGEs in human lens capsule promote the TGFβ2‐mediated EMT of lens epithelial cells: implications for age‐associated fibrosis

Autor: Pankaj Gupta, Marcus A. Glomb, Cibin T. Raghavan, Mareen Smuda, Scott Howell, Dawn Smith, Ram H. Nagaraj, Annapurna Singh, Andrew J. O. Smith, I.M. Wormstone

Publikováno v: Aging Cell

Summary Proteins in basement membrane (BM) are long‐lived and accumulate chemical modifications during aging; advanced glycation endproduct (AGE) formation is one such modification. The human lens capsule is a BM secreted by lens epithelial cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d679e540f20034697c3a7a09cc18ce
https://doi.org/10.1111/acel.12450

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Chemopreventive Activities of Sulforaphane and Its Metabolites in Human Hepatoma HepG2 Cells

Autor: Peng Liu, Yongping Bao, Wei Wang, Zhigang Zhou, Andrew J. O. Smith, Yuqiong Chen, Richard P. Bowater, I.M. Wormstone

Publikováno v: Nutrients; Volume 10; Issue 5; Pages: 585
Nutrients
Nutrients, Vol 10, Iss 5, p 585 (2018)

Sulforaphane (SFN) exhibits chemopreventive effects through various mechanisms. However, few studies have focused on the bioactivities of its metabolites. Here, three metabolites derived from SFN were studied, known as sulforaphane glutathione, sulfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::442e9cd44354ee2d23cf25a5dcac5087

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Sulforaphane promotes ER stress, autophagy and cell death: implications for cataract surgery

Autor: Ningli Wang, Yongping Bao, Simon Sidney Robert Ball, Andrew J. O. Smith, I. Michael Wormstone, Richard P. Bowater, Hanruo Liu

Publikováno v: Journal of Molecular Medicine (Berlin, Germany)

Posterior capsule opacification (PCO) commonly develops following cataract surgery and is a wound-healing response that can ultimately lead to secondary visual loss. Improved management of this problem is required. The isothiocyanate, sulforaphane (S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f619721dd7a9e67920ab91ed0bbd0e
https://ueaeprints.uea.ac.uk/id/eprint/61648/

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Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient

Autor: Andrew M, Cobb, Delphine, Larrieu, Derek T, Warren, Yiwen, Liu, Sonal, Srivastava, Andrew J O, Smith, Richard P, Bowater, Stephen P, Jackson, Catherine M, Shanahan

Publikováno v: Aging Cell

Summary The nuclear lamina is essential for the proper structure and organization of the nucleus. Deregulation of A‐type lamins can compromise genomic stability, alter chromatin organization and cause premature vascular aging. Here, we show that ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8984961febed1cddbf4ead45611c2fd7
https://pubmed.ncbi.nlm.nih.gov/27464478

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Ku80 Counters Oxidative Stress-Induced DNA Damage and Cataract Formation in the Human Lens

Autor: I.M. Wormstone, Richard P. Bowater, Kamal Manzar, Andrew J. O. Smith, Simon Sidney Robert Ball

PURPOSE: Oxidative stress in the human lens leads to a wide range of damage including DNA strand breaks, which are likely to contribute to cataract formation. The protein Ku80 is a fundamental component of the nonhomologous end-joining pathway that r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14538f424fa3cdc06567c6d6832c4a8a
https://ueaeprints.uea.ac.uk/id/eprint/56750/

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