Zobrazeno 1 - 10
of 34
pro vyhledávání: '"J. O. Hui"'
Autor:
Hannah M. Yogasundram, Andrew J. O. Hui, Clifford Y. S. Sia, Anthea C. Chui, William J. Waldock, Siobhan Quenby, Elizabeth Brown, Clare Oliver-Williams
Publikováno v:
Arch Gynecol Obstet
Archives of Gynecology and Obstetrics
Archives of Gynecology and Obstetrics
Funder: Medical Research Council (GB)
Funder: British Heart Foundation; doi: http://dx.doi.org/10.13039/501100000274
Funder: Homerton College, University of Cambridge; doi: http://dx.doi.org/10.13039/501100008420
Funder: University of
Funder: British Heart Foundation; doi: http://dx.doi.org/10.13039/501100000274
Funder: Homerton College, University of Cambridge; doi: http://dx.doi.org/10.13039/501100008420
Funder: University of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca106e43e294f1e1bb2f21f1cb477d1
https://doi.org/10.1007/s00404-020-05836-4
https://doi.org/10.1007/s00404-020-05836-4
Autor:
K. Y. Ng, Karen F. Wilkinson, Bob D. Rush, Chong Kt, Jed F. Fisher, J. O. Hui, Ronald T. Borchardt, T. J. Mcquade, Mary J. Ruwart, I. Islam
Publikováno v:
Journal of Medicinal Chemistry. 37:293-304
The outstanding limitations to the oligopeptide as a therapeutic agent are poor oral availability and rapid biliary clearance. To address these concerns a series of eight peptidic HIV-1 protease inhibitors containing the structural segment of the vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559f0d839b30677b5d72cec429871f9a
https://doi.org/10.1021/jm00028a013
https://doi.org/10.1021/jm00028a013
Autor:
A. M. Mulichak, A G Tomasselli, Suvit Thaisrivongs, Robert L. Heinrikson, K. A. Curry, J. O. Hui, Che-Shen C. Tomich, K. D. Watenpaugh, Tomi K. Sawyer
Publikováno v:
Journal of Biological Chemistry. 268:13103-13109
The crystal structure of human immunodeficiency virus (HIV) type 2 protease has been determined in complexes with peptidic inhibitors Noa-His-Cha psi [CH(OH)CH(OH)]Val-Ile-Amp (U75875) and Qnc-Asn-Cha psi [CH(OH)CH2]Val-Npt(U92163) (where Noa is naph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b4c773816a95a264f124b6c94ef5537
https://doi.org/10.1016/s0021-9258(19)38625-9
https://doi.org/10.1016/s0021-9258(19)38625-9
Autor:
A G Tomasselli, J. O. Hui, Robert L. Heinrikson, Che-Shen C. Tomich, June Lull, David P. Brunner, I M Reardon
Publikováno v:
Journal of Protein Chemistry. 12:323-327
The protease encoded by the human immunodeficiency virus type 1 (HIV-1) was engineered in Escherichia coli as a construct in which the natural 99-residue polypeptide was preceded by an NH2-terminal methionine initiator. Inclusion bodies harboring the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9395ed9d0d99dbd5104a1daf99f573f2
https://doi.org/10.1007/bf01028194
https://doi.org/10.1007/bf01028194
Autor:
W. J. Howe, W. T. Lowther, J. O. Hui, W. G. Tarpley, D. E. Emmert, Chetana Rao, A G Tomasselli, John H. Kinner, V. S. Bradford, D. L. Alexander, Tomi K. Sawyer, B.M. Dunna, Robert A. Conradi, D. L. Decamp, Clark W. Smith, Allen W. Harrison, Charles S. Craik, James Michael Tustin, T. J. Mcquade, Robert L. Heinrikson, Y. Z. Zhang, Philip S. Burton, Jed F. Fisher, Roger A. Poorman, Joseph B. Moon, Jackson B. Hester, D J Staples, L. Liu, P. E. Scarborough, Maggiora Linda Louise
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:819-824
The structure-activity relationships and pharmacophore modeling aspects of a series of HIV PR inhibitors modified at the N- and/or C-terminus of the dipeptide isostere ChaΨ[CH(OH)CH2]Val (Cha, cyclohexylalanine) are reported. The HIV PR binding affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b57d250dd9d5791ff9b0e19fb8eaad6
https://doi.org/10.1016/s0960-894x(00)80673-3
https://doi.org/10.1016/s0960-894x(00)80673-3
Autor:
L. Liu, Alexander Wlodawer, Tomi K. Sawyer, D. L. Decamp, Robert L. Heinrikson, K. O'connell, Ben M. Dunn, Joseph B. Moon, Jackson B. Hester, D J Staples, Mariusz Jaskolski, Jennifer L. Harris, Roger A. Poorman, Heinrich J. Schostarez, Clark W. Smith, A G Tomasselli, J. O. Hui, Charles S. Craik, W. J. Howe, W. T. Lowther
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d23a689ed0032396aa16b956d37ebfc
https://doi.org/10.1002/chin.199307301
https://doi.org/10.1002/chin.199307301
Autor:
J. O. Hui, Ronald T. Borchardt, T. J. Mcquade, I. Islam, Jed F. Fisher, Karen F. Wilkinson, Chong Kt, Bob D. Rush, K. Y. Ng, Mary J. Ruwart
Publikováno v:
ChemInform. 25
The outstanding limitations to the oligopeptide as a therapeutic agent are poor oral availability and rapid biliary clearance. To address these concerns a series of eight peptidic HIV-1 protease inhibitors containing the structural segment of the vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ad2322b122c9ef67b57917280845663
https://doi.org/10.1002/chin.199420242
https://doi.org/10.1002/chin.199420242
Autor:
W. J. Howe, W. T. Lowther, A G Tomasselli, D. E. Emmert, D J Staples, Jackson B. Hester, W. G. Tarpley, J. O. Hui, Ben M. Dunn, John H. Kinner, Robert L. Heinrikson, Y. Z. Zhang, Tomi K. Sawyer, Charles S. Craik, D. L. Decamp, James Michael Tustin, T. J. Mcquade, D. L. Alexander, Allen W. Harrison, P. E. Scarborough, Robert A. Conradi, Jed F. Fisher, Roger A. Poorman, Philip S. Burton, Maggiora Linda Louise, V. S. Bradford, Joseph B. Moon, L. Liu, Clark W. Smith, Chetana Rao
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b99dbead49d3038ea527912ab65dad7
https://doi.org/10.1002/chin.199509217
https://doi.org/10.1002/chin.199509217
Autor:
F M Eckenrode, A G Tomasselli, Robert L. Heinrikson, Martin R. Deibel, H.M. Einspahr, H. A. Zurcher-Neely, J. O. Hui, A F Vosters, David B. Evans, Debasish Chattopadhyay
Publikováno v:
Journal of Biological Chemistry. 267:14227-14232
Active recombinant reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) with an amino-terminal extension containing a hexa-histidine sequence has been prepared in milligram quantities in a pure heterodimeric (p66/p51) form by coo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0ee306d622c5acfbd5880e3f966cf8f
https://doi.org/10.1016/s0021-9258(19)49701-9
https://doi.org/10.1016/s0021-9258(19)49701-9
Autor:
Carol A. Bannow, J. O. Hui, Clark W. Smith, H A Zurcher-Neely, I M Reardon, Martin R. Deibel, A G Tomasselli, Robert L. Heinrikson
Publikováno v:
Journal of Biological Chemistry. 267:10232-10237
The protease from simian immunodeficiency virus (SIV) was chemically synthesized by automated solid-phase technology as an NH2-terminally extended derivative, capped with biotin. Biotin-linker-(SIV protease (1-99)): the linker segment, Gly-Gly-Asp-Ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::432dd7a1144b3613ac8f936d8cd96842
https://doi.org/10.1016/s0021-9258(19)50008-4
https://doi.org/10.1016/s0021-9258(19)50008-4