Zobrazeno 1 - 10
of 87
pro vyhledávání: '"J. O. Dostrovsky"'
Autor:
M. Hodaie, J. O. Dostrovsky, William D. Hutchison, Liu D. Liu, Ian A. Prescott, Andres M. Lozano
Publikováno v:
Neurobiology of Disease, Vol 71, Iss, Pp 24-33 (2014)
Parkinson's disease (PD), characterized by the loss of dopaminergic nigrostriatal projections, is a debilitating neurodegenerative disease which produces bradykinesia, rigidity, tremor and postural instability. The dopamine precursor levodopa (L-Dopa
Publikováno v:
Neurochemical Research. 37:2419-2431
Over the last decade, a series of studies has demonstrated that glia in the central nervous system play roles in many aspects of neuronal functioning including pain processing. Peripheral tissue damage or inflammation initiates signals that alter the
Autor:
J. O. Dostrovsky, Andres M. Lozano, Thomas Wichmann, William D. Hutchison, Olivier Darbin, Myriam Lafreniere-Roula
Publikováno v:
Experimental Neurology. 225:455-458
Dopamine depletion in Parkinson's disease (PD) alters the neuronal activity in basal ganglia circuits. Characterizing these changes in network activity is an important step in understanding the disease and how therapies mitigate symptoms. Non-linear
Autor:
J. O. Dostrovsky, Elena Moro, William D. Hutchison, Andres M. Lozano, Mojgan Hodaie, Ian A. Prescott
Publikováno v:
Brain. 132:309-318
Parkinson's disease, caused by the loss of dopaminergic nigrostriatal projections, is a debilitating neurodegenerative disease characterized by bradykinesia, rigidity, tremor and postural instability. The dopamine precursor levodopa (L-dopa) is the m
Publikováno v:
Neuroscience. 153:832-841
Activation of nociceptors causes them to secrete neuropeptides. The binding of these peptides to receptors on blood vessels causes vasodilation and increased vascular permeability that allows loss of proteins and fluid (plasma extravasation, PE); thi
Publikováno v:
Brain, Behavior, and Immunity. 21:634-641
Central sensitization is a crucial mechanism underlying the increased excitability of nociceptive pathways following peripheral tissue injury and inflammation. We have previously demonstrated that the small-fiber excitant and inflammatory irritant mu
Autor:
Ronald R. Tasker, B. Hu, Andres M. Lozano, Zelma H. T. Kiss, J. O. Dostrovsky, Karen D. Davis
Publikováno v:
Experimental Brain Research. 150:85-94
Increased afferent input may alter receptive field sizes, properties and somatotopographic representation in the cortex. Changes in the motor thalamus may also occur as a result of altered afferent input. Such plasticity has been implicated in both s
Publikováno v:
European journal of pain (London, England). 19(2)
The application to the skin of spatially interlaced innocuous warm (40 °C) and cool (20 °C) thermodes (termed a thermal grill--TG) can produce an unusual thermal percept, but the mechanisms remain unclear.We compared the percept quality and intensi
Publikováno v:
Movement Disorders. 16:208-216
A 69-year-old woman with Parkinson's disease and levodopa-induced dyskinesias had a deep brain stimulation (DBS) electrode inserted into the right globus pallidus internus (GPi). During the operation, the GPi was mapped with dual microelectrode recor
Publikováno v:
Stereotactic and Functional Neurosurgery. 70:1-18
The immediate motor effects of stimulation through electrodes chronically implanted in the globus pallidus internus (GPI) were studied in 9 subjects with Parkinson’s disease. Single stimuli (at ≫0.4 Hz) produced short latency facilitation of volu