Zobrazeno 1 - 10
of 494
pro vyhledávání: '"J. O'Meara"'
Autor:
Matthew J O'Meara, Jackson R Rapala, Connie B Nichols, A Christina Alexandre, R Blake Billmyre, Jacob L Steenwyk, J Andrew Alspaugh, Teresa R O'Meara
Publikováno v:
PLoS Genetics, Vol 20, Iss 2, p e1011158 (2024)
Elucidating gene function is a major goal in biology, especially among non-model organisms. However, doing so is complicated by the fact that molecular conservation does not always mirror functional conservation, and that complex relationships among
Externí odkaz:
https://doaj.org/article/65ef4ddc629c437bbbd2a8ec1d36b4e8
Autor:
Lisa T. Pulianmackal, Jose Miguel I. Limcaoco, Keerthikka Ravi, Sinyu Yang, Jeffrey Zhang, Mimi K. Tran, Maria Ghalmi, Matthew J. O’Meara, Anthony G. Vecchiarelli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract In eukaryotes, linear motor proteins govern intracellular transport and organization. In bacteria, where linear motors involved in spatial regulation are absent, the ParA/MinD family of ATPases organize an array of genetic- and protein-based
Externí odkaz:
https://doaj.org/article/b2ba362315124a9daa8128a168c316a4
Autor:
Dominic J. O'Meara
Knowledge of the structure of the cosmos, Plato suggests, is important in organizing a human community which aims at happiness. This book investigates this theme in Plato's later works, the Timaeus, Statesman, and Laws. Dominic J. O'Meara proposes fr
Autor:
Faith M Anderson, Noelle D Visser, Kevin R Amses, Andrea Hodgins-Davis, Alexandra M Weber, Katura M Metzner, Michael J McFadden, Ryan E Mills, Matthew J O'Meara, Timothy Y James, Teresa R O'Meara
Publikováno v:
PLoS Biology, Vol 21, Iss 5, p e3001822 (2023)
Candida albicans is a frequent colonizer of human mucosal surfaces as well as an opportunistic pathogen. C. albicans is remarkably versatile in its ability to colonize diverse host sites with differences in oxygen and nutrient availability, pH, immun
Externí odkaz:
https://doaj.org/article/cbe3393272d943c6b322bfb756e65996
Autor:
Ci Fu, Xiang Zhang, Amanda O. Veri, Kali R. Iyer, Emma Lash, Alice Xue, Huijuan Yan, Nicole M. Revie, Cassandra Wong, Zhen-Yuan Lin, Elizabeth J. Polvi, Sean D. Liston, Benjamin VanderSluis, Jing Hou, Yoko Yashiroda, Anne-Claude Gingras, Charles Boone, Teresa R. O’Meara, Matthew J. O’Meara, Suzanne Noble, Nicole Robbins, Chad L. Myers, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The analysis of essential genes in pathogens can be used to discover potential antimicrobial targets. Here, the authors use a machine learning model and chemogenomic analyses to generate genome-wide gene essentiality predictions for the fungal pathog
Externí odkaz:
https://doaj.org/article/30b53e35a0bc440e930c93cb62d5cbf8
Autor:
Jesse W. Wotring, Sean M. McCarty, Khadija Shafiq, Charles J. Zhang, Theophilus Nguyen, Sophia R. Meyer, Reid Fursmidt, Carmen Mirabelli, Martin C. Clasby, Christiane E. Wobus, Matthew J. O’Meara, Jonathan Z. Sexton
Publikováno v:
Vaccines, Vol 10, Iss 8, p 1284 (2022)
Niclosamide, an FDA-approved oral anthelmintic drug, has broad biological activity including anticancer, antibacterial, and antiviral properties. Niclosamide has also been identified as a potent inhibitor of SARS-CoV-2 infection in vitro, generating
Externí odkaz:
https://doaj.org/article/487964f7eb2346369351c8a5aaae5f65
Autor:
Cheng-Chia Tang, Christian D Castro Andrade, Maureen J O'Meara, Sung-Hee Yoon, Tadatoshi Sato, Daniel J Brooks, Mary L Bouxsein, Janaina da Silva Martins, Jinhua Wang, Nathanael S Gray, Barbara Misof, Paul Roschger, Stephane Blouin, Klaus Klaushofer, Annegreet Velduis-Vlug, Yosta Vegting, Clifford J Rosen, Daniel O'Connell, Thomas B Sundberg, Ramnik J Xavier, Peter Ung, Avner Schlessinger, Henry M Kronenberg, Rebecca Berdeaux, Marc Foretz, Marc N Wein
Publikováno v:
eLife, Vol 10 (2021)
Bone formation and resorption are typically coupled, such that the efficacy of anabolic osteoporosis treatments may be limited by bone destruction. The multi-kinase inhibitor YKL-05–099 potently inhibits salt inducible kinases (SIKs) and may repres
Externí odkaz:
https://doaj.org/article/df0d71f913fb4c5a97707f2fd4b38a59
Autor:
J. O'Meara, Gregory
Publikováno v:
Federal Sentencing Reporter, 2010 Oct . 23(1), 33-38.
Externí odkaz:
https://www.jstor.org/stable/10.1525/fsr.2010.23.1.33
Autor:
Teresa R. O’Meara, Matthew J. O’Meara
Publikováno v:
mSphere, Vol 6, Iss 1 (2021)
Candida albicans
Externí odkaz:
https://doaj.org/article/506963dfa1af4121b2ed975909e8e7aa
Autor:
Teresa R O'Meara, Matthew J O'Meara, Elizabeth J Polvi, M Reza Pourhaghighi, Sean D Liston, Zhen-Yuan Lin, Amanda O Veri, Andrew Emili, Anne-Claude Gingras, Leah E Cowen
Publikováno v:
PLoS Biology, Vol 17, Iss 7, p e3000358 (2019)
Hsp90 is a conserved molecular chaperone that assists in the folding and function of diverse cellular regulators, with a profound impact on biology, disease, and evolution. As a central hub of protein interaction networks, Hsp90 engages with hundreds
Externí odkaz:
https://doaj.org/article/b7738dbd09824335b714a967c9ef22d6