Zobrazeno 1 - 10
of 926
pro vyhledávání: '"J. O'Donoghue"'
Autor:
L. Johnson, P. White, R. Jeevan, J. Browne, C. Gulliver-Clarke, J. O’Donoghue, S. Mohiuddin, W. Hollingworth, P. Fairbrother, M. MacKenzie, C. Holcombe, S. Potter
Publikováno v:
Breast, Vol 68, Iss , Pp S89- (2023)
Externí odkaz:
https://doaj.org/article/f2a0efd14ca041639a63e2b074f82e12
Autor:
Jan Silhan, Pavla Fajtova, Jitka Bartosova, Brianna M. Hurysz, Jehad Almaliti, Yukiko Miyamoto, Lars Eckmann, William H. Gerwick, Anthony J. O’Donoghue, Evzen Boura
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The proteasome is a proteolytic enzyme complex essential for protein homeostasis in mammalian cells and protozoan parasites like Trichomonas vaginalis (Tv), the cause of the most common, non-viral sexually transmitted disease. Tv and other p
Externí odkaz:
https://doaj.org/article/abd0f24bf800449e83e758d89f1c5a2b
Autor:
Lawrence J. Liu, Bobby Lucero, Cindy Manriquez-Rodriguez, Karol R. Francisco, Thaiz R. Teixeira, Darius J. Yohannan, Carlo Ballatore, Samuel A. Myers, Anthony J. O’Donoghue, Conor R. Caffrey
Publikováno v:
ACS Omega, Vol 9, Iss 32, Pp 34829-34840 (2024)
Externí odkaz:
https://doaj.org/article/216d446cd15c4572865786ea4be7e282
Small molecule in situ resin capture provides a compound first approach to natural product discovery
Autor:
Alexander Bogdanov, Mariam N. Salib, Alexander B. Chase, Heinz Hammerlindl, Mitchell N. Muskat, Stephanie Luedtke, Elany Barbosa da Silva, Anthony J. O’Donoghue, Lani F. Wu, Steven J. Altschuler, Tadeusz F. Molinski, Paul R. Jensen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Culture-based microbial natural product discovery strategies fail to realize the extraordinary biosynthetic potential detected across earth’s microbiomes. Here we introduce Small Molecule In situ Resin Capture (SMIRC), a culture-independen
Externí odkaz:
https://doaj.org/article/7ba9d42708bb45c1a8547a7ae7e75601
Autor:
Jehad Almaliti, Momen Alhindy, Michael C. Yoon, Vivian Hook, Tadeusz F. Molinski, Anthony J. O’Donoghue, William H. Gerwick
Publikováno v:
ACS Omega, Vol 9, Iss 3, Pp 3997-4003 (2024)
Externí odkaz:
https://doaj.org/article/c37339e22da74790a82befae2753392d
Autor:
Michael Sveiven, Ana K. Serrano, Joshua Rosenberg, Douglas J. Conrad, Drew A. Hall, Anthony J. O’Donoghue
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Hydrolytic enzymes play crucial roles in cellular processes, and dysregulation of their activities is implicated in various physiological and pathological conditions. These enzymes cleave substrates such as peptide bonds, phosphodiester bonds, glycos
Externí odkaz:
https://doaj.org/article/3381328e55a7414eac211cc26e255b75
Autor:
Natalie Sirisaengtaksin, Eloise J. O'Donoghue, Sara Jabbari, Andrew J. Roe, Anne Marie Krachler
Publikováno v:
mSphere, Vol 8, Iss 6 (2023)
ABSTRACTOuter membrane vesicles (OMVs) are proteoliposomes shed by Gram-negative bacteria. Their secretion is enhanced by the transition into the intra-host milieu, and OMVs play critical roles during pathogenesis. Enterohemorrhagic Escherichia coli
Externí odkaz:
https://doaj.org/article/b235a442b5504fafa8012d2a6503453f
Autor:
Raphael Reher, Allegra T. Aron, Pavla Fajtová, Paolo Stincone, Berenike Wagner, Alicia I. Pérez-Lorente, Chenxi Liu, Ido Y. Ben Shalom, Wout Bittremieux, Mingxun Wang, Kyowon Jeong, Marie L. Matos-Hernandez, Kelsey L. Alexander, Eduardo J. Caro-Diaz, C. Benjamin Naman, J. H. William Scanlan, Phil M. M. Hochban, Wibke E. Diederich, Carlos Molina-Santiago, Diego Romero, Khaled A. Selim, Peter Sass, Heike Brötz-Oesterhelt, Chambers C. Hughes, Pieter C. Dorrestein, Anthony J. O’Donoghue, William H. Gerwick, Daniel Petras
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Bioactivity-guided isolation of specialized metabolites is an iterative process. Here, the authors demonstrate a native metabolomics approach that allows for fast screening of complex metabolite extracts against a protein of interest and simultaneous
Externí odkaz:
https://doaj.org/article/b4de9418b20d4c4ebe6ea5392f4b3a2b
Autor:
Sonia Podvin, Alexander Jones, Qing Liu, Brent Aulston, Charles Mosier, Janneca Ames, Charisse Winston, Christopher B. Lietz, Zhenze Jiang, Anthony J. O’Donoghue, Tsuneya Ikezu, Robert A. Rissman, Shauna H. Yuan, Vivian Hook
Publikováno v:
ACS Omega, Vol 6, Iss 20, Pp 13033-13056 (2021)
Externí odkaz:
https://doaj.org/article/85df60e77971439a9aa48ddc16680670
Autor:
Ittipat Meewan, Xingquan Zhang, Suchismita Roy, Carlo Ballatore, Anthony J. O’Donoghue, Robert T. Schooley, Ruben Abagyan
Publikováno v:
ACS Omega, Vol 4, Iss 16, Pp 16999-17008 (2019)
Externí odkaz:
https://doaj.org/article/031cd9edd34b4ffc82d9547db618b6a8