Development of Focused Ultrasound-Assisted Nanoplexes for RNA Delivery

Autor: Sanjeev Ranjan, Stef Bosch, Hannamari Lukkari, Johanna Schirmer, Niina Aaltonen, Heikki J. Nieminen, Vesa-Pekka Lehto, Arto Urtti, Tatu Lajunen, Kirsi Rilla

Publikováno v: Nanomaterials, Vol 14, Iss 13, p 1089 (2024)

RNA-based therapeutics, including siRNA, have obtained recognition in recent years due to their potential to treat various chronic and rare diseases. However, there are still limitations to lipid-based drug delivery systems in the clinical use of RNA

Externí odkaz: https://doaj.org/article/50ce1e20b7f44f92b42fd60f0f06139a

Needle bevel geometry influences the flexural deflection magnitude in ultrasound-enhanced fine-needle biopsy

Autor: Saif Bunni, Heikki J. Nieminen

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract It has been recently demonstrated that use of ultrasound increases the tissue yield in ultrasound-enhanced fine-needle aspiration biopsy (USeFNAB) as compared to conventional fine-needle aspiration biopsy (FNAB). To date, the association bet

Externí odkaz: https://doaj.org/article/00a5914a5aae4a83bdecb20f8f566d39

Non-contact determination of intra-ocular pressure in an ex vivo porcine model.

Autor: Ari Salmi, Heikki J Nieminen, Daniel Veira Canle, Edward Hæggström, Antti Kontiola

Publikováno v: PLoS ONE, Vol 15, Iss 2, p e0227488 (2020)

People suffering from glaucoma often endure high intra-ocular pressure (IOP). Methods for determining IOP either contact the eye or are unpleasant to some patients. There is therefore a need for a rapid and patient friendly non-contacting method to d

Externí odkaz: https://doaj.org/article/2526f875539247bb8e62eb3e952996a6

Laser-ultrasonic delivery of agents into articular cartilage

Autor: Heikki J. Nieminen, Gonçalo Barreto, Mikko A. Finnilä, Alejandro García-Pérez, Ari Salmi, Sanjeev Ranjan, Kari K. Eklund, Kenneth P. H. Pritzker, Simo Saarakkala, Edward Hæggström

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Abstract Research is ongoing to develop drug therapies to manage osteoarthritis (OA) and articular cartilage (AC) injuries. However, means to deliver drug to localized AC lesions are highly limited and not clinically available. This study investigate

Externí odkaz: https://doaj.org/article/4c04c73ebf2b43d4b65dd64e478ad414

Safety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial

Autor: Melinda B Roaldsen, Agnethe Eltoft, Tom Wilsgaard, Hanne Christensen, Stefan T Engelter, Bent Indredavik, Dalius Jatužis, Guntis Karelis, Janika Kõrv, Erik Lundström, Jesper Petersson, Jukka Putaala, Mary-Helen Søyland, Arnstein Tveiten, Andrew Bivard, Stein Harald Johnsen, Michael V Mazya, David J Werring, Teddy Y Wu, Gian Marco De Marchis, Thompson G Robinson, Ellisiv B Mathiesen, M Parson, M Valente, A Chen, A Sharobeam, L Edwards, C Blair, L Christensen, K Ægidius, T Pihl, C Fassel-Larsen, L Wassvik, M Folke, S Rosenbaum, S S Gharehbagh, A Hansen, N Preisler, K Antsov, S Mallene, M Lill, M Herodes, R Vibo, A Rakitin, J Saarinen, M Tiainen, O Tumpula, T Noppari, S Raty, G Sibolt, J Nieminen, J Niederhauser, I Haritoncenko, J Puustinen, T-M Haula, J Sipilä, B Viesulaite, S Taroza, D Rastenyte, V Matijosaitis, A Vilionskis, R Masiliunas, A Ekkert, P Chmeliauskas, V Lukosaitis, A Reichenbach, T T Moss, H Y Nilsen, R Hammer-Berntzen, L M Nordby, T A Weiby, K Nordengen, H Ihle-Hansen, M Stankiewiecz, O Grotle, M Nes, K Thiemann, I M Særvold, M Fraas, S Størdahl, J W Horn, H Hildrum, C Myrstad, H Tobro, J-A Tunvold, O Jacobsen, N Aamodt, H Baisa, V N Malmberg, G Rohweder, H Ellekjær, F Ildstad, E Egstad, B H Helleberg, H H Berg, J Jørgensen, E Tronvik, M Shirzadi, R Solhoff, R Van Lessen, A Vatne, K Forselv, H Frøyshov, M S Fjeldstad, L Tangen, S Matapour, K Kindberg, C Johannessen, M Rist, I Mathisen, T Nyrnes, A Haavik, G Toverud, K Aakvik, M Larsson, K Ytrehus, S Ingebrigtsen, T Stokmo, C Helander, I C Larsen, T O Solberg, Y M Seljeseth, S Maini, I Bersås, J Mathé, E Rooth, A-C Laska, A-S Rudberg, M Esbjörnsson, F Andler, A Ericsson, O Wickberg, J-E Karlsson, P Redfors, K Jood, F Buchwald, K Mansson, O Gråhamn, K Sjölin, E Lindvall, Å Cidh, A Tolf, O Fasth, B Hedström, J Fladt, T D Dittrich, L Kriemler, N Hannon, E Amis, S Finlay, J Mitchell-Douglas, J McGee, R Davies, V Johnson, A Nair, M Robinson, J Greig, O Halse, P Wilding, S Mashate, K Chatterjee, M Martin, S Leason, J Roberts, D Dutta, D Ward, R Rayessa, E Clarkson, J Teo, C Ho, S Conway, M Aissa, V Papavasileiou, S Fry, D Waugh, J Britton, A Hassan, L Manning, S Khan, A Asaipillai, C Fornolles, M L Tate, S Chenna, T Anjum, D Karunatilake, J Foot, L VanPelt, A Shetty, G Wilkes, A Buck, B Jackson, L Fleming, M Carpenter, L Jackson, A Needle, T Zahoor, T Duraisami, K Northcott, J Kubie, A Bowring, S Keenan, D Mackle, T England, B Rushton, A Hedstrom, S Amlani, R Evans, G Muddegowda, A Remegoso, P Ferdinand, R Varquez, M Davis, E Elkin, R Seal, M Fawcett, C Gradwell, C Travers, B Atkinson, S Woodward, L Giraldo, J Byers, B Cheripelli, S Lee, R Marigold, S Smith, L Zhang, R Ghatala, C H Sim, U Ghani, K Yates, S Obarey, M Willmot, K Ahlquist, M Bates, K Rashed, S Board, G Andsberg, S Sundayi, M Garside, M-J Macleod, A Manoj, O Hopper, B Cederin, T Toomsoo, K Gross-Paju, T Tapiola, J Kestutis, K-F Amthor, B Heermann, V Ottesen, T A Melum, M Kurz, M Parsons

Publikováno v: The Lancet. Neurology.

Current evidence supports the use of intravenous thrombolysis with alteplase in patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in clinical guidelines. However, access to advanced imaging techniques is often sca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77e948b8214830b257c18297ff5e11d
https://pubmed.ncbi.nlm.nih.gov/36549308