A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development

Autor: D. K. Walker, Joseph T. Brady, John D. Davis, Martin E. Dowty, Patricia Wright, Deepak Dalvie, Angus N. R. Nedderman, J. Neil Duncan, R. Scott Obach

Publikováno v: Chemical Research in Toxicology. 22:1653-1662

The subject of metabolites in safety testing has had much debate in the recent past and has shown itself to be a complex issue with no simple solutions to providing absolute assurance of drug safety. Much of the attention has focused on the ability t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a1e34a42af6a08771fdcd4a35f3ed1
https://doi.org/10.1021/tx900213j

Dopamine D3 Receptor Antagonists. 1. Synthesis and Structure−Activity Relationships of 5,6-Dimethoxy-N-alkyl- and N-Alkylaryl-Substituted 2-Aminoindans

Autor: Martin W. Smith, Kjell Svensson, Matt J. Zaya, Susanne R. Haadsma-Svensson, Mary E. Lajiness, Nanette F. Nichols, Chiu-Hong Lin, Rita M. Huff, Christopher L. Haber, Kerry Anne Cleek, J. Neil Duncan, Dac M. Dinh, and Arvid Carlsson

Publikováno v: Journal of Medicinal Chemistry. 44:4716-4732

5,6-Dimethoxy-2-(N-dipropyl)-aminoindan (3, PNU-99194A) was found to be a selective dopamine D(3) receptor antagonist with potential antipsychotic properties in animal models. To investigate the effects of nitrogen substitution on structure-activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50895a57b406c01e185736e122556b86
https://doi.org/10.1021/jm010145w

Contributors

Autor: Mohamoud M. Abdi, Nabil Hussain Al-Humadi, Mayssa Attar, Theodore J. Baird, Jeff Behrens, Nathan Boersen, Jacqueline A. Brassard, Melissa J. Beck, Jennifer G. Brown, Edward W. Carney, Ting-Tung A. Chang, Mingli Chen, Dorothy B. Colagiovanni, John B. Colerangle, Roger Collins, Rebecca Dabora, Jill A. Dalton, Kevin H. Denny, Rodney R. Dietert, Forbes P. Donald, J. Neil Duncan, John T. Farmer, Ali S. Faqi, Stephen Frantz, Les Freshwater, Tobias C. Fuchs, David V. Gauvin, Martin David Green, Lining Guo, Scott P. Henry, Philip G. Hewitt, Alan Hoberman, Ho-Wah Hui, Julia Y. Hui, Colleen Johnson, John W. Kille, Andrea S. Kim, Tae-Won Kim, Neil Kirby, Douglas Kornbrust, Douglas B. Learn, Thomas Lee, Elise Lewis, Steven Matsumoto, David L. McCormick, Kathleen B. Meyer-Tamaki, Odete R. Mendes, Michael V. Milburn, Igor Mikaelian, LaRonda L. Morford, John Nicolette, Paul Nugent, Hyesun H. Oh, Lekan Oyejide, Meg Ramos, Kelly A. Regal, David Rehagen, John Cody Resendez, John A. Ryals, Christopher P. Sambuco, Michael Schrag, David G. Serota, Raja Settivari, Richard Slauter, Christopher W. Stewart, Donald Stump, Sekhar Surapaneni, Michael Templin, Bjorn A. Thorsrud, Germaine L. Truisi, Chang Vangyi, Tom Vidmar, Jim Vrbanac, Qingli Wang, Zheng J. Wang, Lawrence O. Whitely, James S. Yan, Malcolm J. York, Husam S. Younis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2aa595349a72c0097cbac46cf9de6668
https://doi.org/10.1016/b978-0-12-387815-1.10037-1

Azithromycin/chloroquine combination does not increase cardiac instability despite an increase in monophasic action potential duration in the anesthetized guinea pig

Autor: J. Neil Duncan, Shibing Deng, Todd Wisialowski, Anthony A. Fossa, Michael Dunne

Publikováno v: The American journal of tropical medicine and hygiene. 77(5)

Prolongation of the electrocardiogram QT interval by some, but not all drugs, has been associated with increased incidence of sudden cardiac death. Current preclinical regulatory assays cannot discriminate the arrhythmia liability of these drugs. Con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8169c2a804689f8d3c99df6cc3fdde8
https://pubmed.ncbi.nlm.nih.gov/17984356

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