Výsledky vyhledávání - "J. Neil Duncan"

Calculation of a permitted daily exposure value for the solvent 2-methyltetrahydrofuran

Autor: Patricia Parris, J. Neil Duncan, William P. Beierschmitt, Andrew Fleetwood

Publikováno v: Regulatory Toxicology and Pharmacology. 87:54-63

In response to increasing concerns around the potential environmental impact of industrial chemicals, the pharmaceutical industry is seeking alternatives for traditional solvents used during the manufacturing process. Taking into consideration the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90d523a74862a1dfebf670b0b12b2fb
https://doi.org/10.1016/j.yrtph.2017.04.012

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A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development

Autor: D. K. Walker, Joseph T. Brady, John D. Davis, Martin E. Dowty, Patricia Wright, Deepak Dalvie, Angus N. R. Nedderman, J. Neil Duncan, R. Scott Obach

Publikováno v: Chemical Research in Toxicology. 22:1653-1662

The subject of metabolites in safety testing has had much debate in the recent past and has shown itself to be a complex issue with no simple solutions to providing absolute assurance of drug safety. Much of the attention has focused on the ability t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a1e34a42af6a08771fdcd4a35f3ed1
https://doi.org/10.1021/tx900213j

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COMPARISON OF PREDICTION METHODS FOR IN VIVO CLEARANCE OF (S,S)-3-[3-(METHYLSULFONYL)PHENYL]-1-PROPYLPIPERIDINE HYDROCHLORIDE, A DOPAMINE D2 RECEPTOR ANTAGONIST, IN HUMANS

Autor: Shinji Yamazaki, Lisa N. Toth, J. Neil Duncan, Meredith L. Black

Publikováno v: Drug Metabolism and Disposition. 32:398-404

The purpose of this study is to investigate reliable prediction methods for in vivo pharmacokinetics and the likelihood of drug interactions with several cytochrome P450 inhibitors in humans for (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d6c6a650ec190d8008c5cd6cb5149e
https://doi.org/10.1124/dmd.32.4.398

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Dopamine D3 Receptor Antagonists. 1. Synthesis and Structure−Activity Relationships of 5,6-Dimethoxy-N-alkyl- and N-Alkylaryl-Substituted 2-Aminoindans

Autor: Martin W. Smith, Kjell Svensson, Matt J. Zaya, Susanne R. Haadsma-Svensson, Mary E. Lajiness, Nanette F. Nichols, Chiu-Hong Lin, Rita M. Huff, Christopher L. Haber, Kerry Anne Cleek, J. Neil Duncan, Dac M. Dinh, and Arvid Carlsson

Publikováno v: Journal of Medicinal Chemistry. 44:4716-4732

5,6-Dimethoxy-2-(N-dipropyl)-aminoindan (3, PNU-99194A) was found to be a selective dopamine D(3) receptor antagonist with potential antipsychotic properties in animal models. To investigate the effects of nitrogen substitution on structure-activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50895a57b406c01e185736e122556b86
https://doi.org/10.1021/jm010145w

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Substituted 4-aminopiperidines having high in vitro affinity and selectivity for the cloned human dopamine D4 receptor

Autor: J. Neil Duncan, Schlachter Sk, Arthur Glenn Romero, Mary E. Lajiness, Toni J Poel, Martin W. Smith, Dac M. Dinh, Lawson Cf, Susan A Rees

Publikováno v: European Journal of Pharmacology. 322:283-286

We have discovered two substituted 4-aminopiperidine compounds having high in vitro affinity and selectivity for the human dopamine D 4 receptor. Both compounds, 3-ethoxy- N -methyl- N -[1-(phenylmethyl)-4-piperidinyl]-2-pyridinylamine (U-99363E), an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149a833614eabe68936f81daa9e50eee
https://doi.org/10.1016/s0014-2999(97)00013-7

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Synthesis and biological activity of C-5 modified derivatives of (+)-AJ76 and (+)-UH232: Increased dopamine D3 receptor preference and improved pharmacokinetic properties

Autor: Kjell Svensson, Nicholas Waters, Clas Sonesson, J. Neil Duncan, Arvid Carlsson, H»kan Wikström, M. W. Smith, Chiu-Hong Lin, Susanne R. Haadsma-Svensson

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:689-694

A series of (+)-AJ76 and (+)-UH232 analogs with the C-5 methoxy group modified was synthesized and biologically evaluated. Compounds with a triflate or nitrile group were found to be behavioral stimulants with high metabolic stability. The triflate a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::424a5e415ffdb26beddfb35c84ee134c
https://doi.org/10.1016/s0960-894x(01)80181-5

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Azithromycin/chloroquine combination does not increase cardiac instability despite an increase in monophasic action potential duration in the anesthetized guinea pig

Autor: J. Neil Duncan, Shibing Deng, Todd Wisialowski, Anthony A. Fossa, Michael Dunne

Publikováno v: The American journal of tropical medicine and hygiene. 77(5)

Prolongation of the electrocardiogram QT interval by some, but not all drugs, has been associated with increased incidence of sudden cardiac death. Current preclinical regulatory assays cannot discriminate the arrhythmia liability of these drugs. Con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8169c2a804689f8d3c99df6cc3fdde8
https://pubmed.ncbi.nlm.nih.gov/17984356

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Strategies for bioanalysis of an oligonucleotide class macromolecule from rat plasma using liquid chromatography-tandem mass spectrometry

Autor: Jian Lin, Olga Kavetskaia, Karthik Srinivasan, J Neil Duncan, Guodong Zhang

Publikováno v: Analytical chemistry. 79(9)

Electrospray ionization (ESI) liquid chromatography-tandem mass spectrometry (LC/MS/MS) assays provide high-throughput and selective methods for quantitation of small molecules. Use of LC/MS/MS assays for macromolecules, like oligonucleotides, is cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eda70c265b0beb485212732b5e5bf59
https://pubmed.ncbi.nlm.nih.gov/17394287

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Akademický článek

Reproducible Green Syntheses Using Hybrid Sol-Gel Catalysts.

Autor: Ciriminna R; Istituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, 90146, Palermo, Italy., Luque R; Universidad ECOTEC, Km 13.5 Samborondón, Samborondón, EC092302, Ecuador., Pagliaro M; Istituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, 90146, Palermo, Italy.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Sep 05; Vol. 30 (50), pp. e202402071. Date of Electronic Publication: 2024 Aug 20.

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