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Akademický článek

FBH1 Catalyzes Regression of Stalled Replication Forks

Autor: Kasper Fugger, Martin Mistrik, Kai J. Neelsen, Qi Yao, Ralph Zellweger, Arne Nedergaard Kousholt, Peter Haahr, Wai Kit Chu, Jiri Bartek, Massimo Lopes, Ian D. Hickson, Claus Storgaard Sørensen

Publikováno v: Cell Reports, Vol 10, Iss 10, Pp 1749-1757 (2015)

DNA replication fork perturbation is a major challenge to the maintenance of genome integrity. It has been suggested that processing of stalled forks might involve fork regression, in which the fork reverses and the two nascent DNA strands anneal. He

Externí odkaz: https://doaj.org/article/3fc71f988a5d4155a5e024d81cc079aa

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Mutation Frequency Dynamics inHPRTLocus in Culture-Adapted Human Embryonic Stem Cells and Induced Pluripotent Stem Cells Correspond to Their Differentiated Counterparts

Autor: Jan Raška, Michal Franek, Stanislava Košková, Anton Salykin, Aneta Baumeisterová, Kai J. Neelsen, Eva Bártová, Aleš Hampl, Vladimír Rotrekl, Lenka Zerzankova, Monika Šeneklová, Martin Pešl, Miriama Krutá, Petr Dvořák

Publikováno v: Stem Cells and Development. 23:2443-2454

The genomic destabilization associated with the adaptation of human embryonic stem cells (hESCs) to culture conditions or the reprogramming of induced pluripotent stem cells (iPSCs) increases the risk of tumorigenesis upon the clinical use of these c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c617841cdc9ccc0ed3594199d0c636
https://doi.org/10.1089/scd.2013.0611

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Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

Autor: Kai J. Neelsen, Massimo Lopes, Raquel Herrador, Isabella M.Y. Zanini

Publikováno v: The Journal of cell biology
The Journal of Cell Biology

Processing of unusual replication intermediates such as reversed forks by MUS81 contributes to oncogene-induced double-strand breaks and depends on mitotic entry.
Oncogene-induced DNA replication stress activates the DNA damage response (DDR), a

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Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells

Autor: Alessandro A. Sartori, Behnam Kalali, Anne Müller, Martin Steger, Manuel Stucki, Markus Gerhard, Massimo Lopes, Kai J. Neelsen, Isabella M. Toller, Mara L. Hartung, Michael O. Hottiger

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

The bacterial pathogen Helicobacter pylori chronically infects the human gastric mucosa and is the leading risk factor for the development of gastric cancer. The molecular mechanisms of H. pylori -associated gastric carcinogenesis remain ill defined.

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Replication fork reversal in eukaryotes: from dead end to dynamic response

Autor: Kai J. Neelsen, Massimo Lopes

Publikováno v: Nature reviews. Molecular cell biology

The remodelling of replication forks into four-way junctions following replication perturbation, known as fork reversal, was hypothesized to promote DNA damage tolerance and repair during replication. Albeit conceptually attractive, for a long time f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44d6eefe68246ed4aba702a03293737
https://doi.org/10.5167/uzh-109568

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New histone supply regulates replication fork speed and PCNA unloading

Autor: Albin Sandelin, Philippe Pasero, Zuzana Jasencakova, Jakob Mejlvang, Yunpeng Feng, Kai J. Neelsen, Massimo Lopes, Anja Groth, Xiaobei Zhao, Constance Alabert, Michael Lees

Publikováno v: The Journal of Cell Biology
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2014, 204 (1), pp.29-43. ⟨10.1083/jcb.201305017⟩
The Journal of cell biology

Coupling of replication fork speed and PCNA unloading to nucleosome assembly may maintain chromatin integrity during transient histone shortage.
Correct duplication of DNA sequence and its organization into chromatin is central to genome functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962217bc15eaf4940f44bbafa6cef337

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Visualization and interpretation of eukaryotic DNA replication intermediates in vivo by electron microscopy

Autor: Raquel Herrador, Cindy Follonier, Kai J. Neelsen, Massimo Lopes, Arnab Ray Chaudhuri

Publikováno v: Methods in Molecular Biology ISBN: 9781627037051

The detailed understanding of the DNA replication process requires structural insight. The combination of psoralen cross-linking and electron microscopy has been extensively exploited to reveal the fine architecture of in vivo DNA replication interme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ea3725bd59866376969ac1f6d862e7

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Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template

Autor: J. Julian Blow, Raquel Herrador, Kai J. Neelsen, Kevin D. Creavin, Sofija Mijic, Isabella M.Y. Zanini, Massimo Lopes, Ralph Zellweger, Arnab Ray Chaudhuri

Publikováno v: Genes & Development, 27 (23)
Genes & development

Deregulated origin licensing and rereplication promote genome instability and tumorigenesis by largely elusive mechanisms. Investigating the consequences of Early mitotic inhibitor 1 (Emi1) depletion in human cells, previously associated with rerepli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327708385a3b26de503e451ffd491666
https://hdl.handle.net/20.500.11850/102691

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Visualization and interpretation of eukaryotic DNA replication intermediates in vivo by electron microscopy

Autor: Kai J, Neelsen, Arnab Ray, Chaudhuri, Cindy, Follonier, Raquel, Herrador, Massimo, Lopes

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1094

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d159b7f071762f5ec399989e1a989c47
https://pubmed.ncbi.nlm.nih.gov/24162989

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Topoisomerase I poisoning results in PARP-mediated replication fork reversal

Autor: Vincenzo Costanzo, Arnab Ray Chaudhuri, Andrea Cocito, Rodrigo Bermejo, Yoshitami Hashimoto, Kai J. Neelsen, Raquel Herrador, Daniele Fachinetti, Massimo Lopes

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Topoisomerase I (Top1) releases torsional stress during DNA replication and transcription and is inhibited by camptothecin and camptothecin-derived cancer chemotherapeutics. Top1 inhibitor cytotoxicity is frequently linked to double-strand break (DSB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ccd4a8f64bce773d2f7778919c85749
http://hdl.handle.net/10261/67538

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